A comparative study on ultrasound-guided elite, Mammotome, and core needle biopsy for diagnosing malignant breast masses

Abstract

Introduction: The present study aims to clarify the advantages and disadvantages of elite biopsy, to provide a reference for selecting the puncture method. Material and methods: A total of 802 patients with a BI-RADS grade ≥ 4, as evaluated by the molybdenum target, and measurable lesions revealed by colour Doppler ultrasound, who were admitted at our department from January 2017 to January 2018, were enrolled in the present study. These patients were randomly divided into three groups: elite, Mammotome and core needle biopsy groups. The pathological underestimation rate, diagnostic accordance rate, haematoma incidence rate, and costs of these three biopsy methods were compared. Results: The difference in diagnostic accordance rates between the elite biopsy group and core needle biopsy group was statistically significant (98.9% vs. 94.7%, p = 0.003), as well as between the Mammotome biopsy group and core needle biopsy group (99.6% vs. 94.7%, p < 0.001). The difference in pathological underestimation rates between the elite biopsy group and core needle biopsy group was statistically significant (7.2% vs. 37.3%, p < 0.001), as well as between the Mammotome biopsy group and core needle biopsy group (1.6% vs. 7.2%, p < 0.001). The difference between the Mammotome biopsy group and elite biopsy group was not statistically significant. The incidence of haematoma in the Mommotome, elite, and core needle groups was 15.9%, 13%, and 21.7%, respectively (13% vs. 21.7%, p = 0.021). Conclusions: Elite biopsy has a low rate of pathological underestimation and low incidence of haematoma, can improve the breast conserving rate, and has an affordable cost. As a biopsy method with high accuracy, safety, and economy, elite biopsy can be widely used in clinics.

The efficacy of norepinephrine application in Mammotome-assisted minimally invasive resection for benign breast neoplasm: A retrospective study Running title：norepinephrine application in benign breast neoplasm

“…Simultaneously, the administration of norepinephrine in MAMIR surgery was safe and no one experienced adverse reactions. Meanwhile, on the basis of a minimally invasive approach, MAMIR with the application of norepinephrine was more effective in reducing intraoperative hemorrhage, relieving postoperative pain, and shortening hospitalization time, which is consistent with the previous study and can better improve the clinical effect of MAMIR, although previous research reports have not involved the role of norepinephrine in the treatment of breast masses with MAMIR [2,6,7,15] .…”

“…Actually, mammotome-assisted minimally invasive technology has also been widely used in the diagnosis of breast masses and the resection of benign masses and/or nodules [2,15,16] . More than that, mammotome-assisted minimally invasive technology has even been used in auxiliary endoscopic breastconserving surgery to provide auxiliary treatment for patients with early-stage breast cancer [17] .…”

“…Breast tumors are a common disease in women, with a wide spectrum of pathologies, ranging from benign hyperplasia, high-risk lesions, and precancerous lesions to invasive malignant tumors [1,2] .…”

Risk factors of breast malignant lesions in patients with ultrasound BI-RADS 3, 4a and 4b undergoing Mammotome minimally invasive surgery

“…This can not only obtain the histological specimens of the breast lesions, but also satisfy the cosmetic psychology of the patients. 19 . If the unfortunate fact is that the pathological result is malignant, patients will inevitably need another breast surgery to expand the scope of lesion resection and follow-up selective radiotherapy and chemotherapy to prevent the spread of tumor cells.…”

Vacuum-assisted biopsy system for breast lesions: a potential therapeutic approach

“…Patients who suspected their lesion to be benign were advised to consider MIS as an option. It not only fulfills the patients' aesthetic concerns but also successfully achieves the therapeutic objective, thereby enhancing overall patient satisfaction (22,23). This study conducted a comprehensive review and analysis of the clinical characteristics and imaging data of female patients with BI-RADS 3, 4a, and 4b lesions who underwent Mammotome MIS.…”