A comparative study to evaluate the effect of limited access dressing on diabetic ulcers

Honnegowda, Thittamaranahalli Muguregowda; Kumar, Pramod; Prabhu, Krishnananda; Kumar, Ashwini; Rao, Pragna; Udupa, E. G. Padmanabha; Kamath, Shobha; Souza, Antony Sylvan D; Mahato, Krishna Kishore

doi:10.4103/2347-9264.165448

Cited by 24 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This also hampers the use of SKOs for treating diabetic, ischemic, and venous insufficiency ulcers due to hypoxic conditions and a lack of micronutrients. [ 30 ] The idea of developing human vascularized organoids has been tested in brain organoids. The results showed that iPSC‐derived endothelial cells auto‐assembled to tubular structures and capillaries had penetrated toward the center of organoids in vitro.…”

Section: Discussionmentioning

confidence: 99%

Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells

Shafiee,

Sun,

Ahmed

et al. 2023

Small

View full text Add to dashboard Cite

The development of skin organs for studying developmental pathways, modeling diseases, or regenerative medicine purposes is a major endeavor in the field. Human induced pluripotent stem cells (hiPSCs) are successfully used to derive skin cells, but the field is still far from meeting the goal of creating skin containing appendages, such as hair follicles and sweat glands. Here, the goal is to generate skin organoids (SKOs) from human skin fibroblast or placental CD34+ cell‐derived hiPSCs. With all three hiPSC lines, complex SKOs with stratified skin layers and pigmented hair follicles are generated with different efficacies. In addition, the hiPSC‐derived SKOs develop sebaceous glands, touch‐receptive Merkel cells, and more importantly eccrine sweat glands. Together, physiologically relevant skin organoids are developed by direct induction of embryoid body formation, along with simultaneous inactivation of transforming growth factor beta signaling, activation of fibroblast growth factor signaling, and inhibition of bone morphogenetic protein signaling pathways. The skin organoids created in this study can be used as valuable platforms for further research into human skin development, disease modeling, or reconstructive surgeries.

show abstract

Section: Discussionmentioning

confidence: 99%

Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells

Shafiee,

Sun,

Ahmed

et al. 2023

Small

View full text Add to dashboard Cite

show abstract

“…The process is stimulated by the release of multiple factors during the inflammatory phase, driven by hypoxia, and gradually stabilizes and diminishes as inflammation subsides. [98] Jacobsen et al recently demonstrated that in cases of subthreshold or mild volumetric muscle loss (VML), the formation of nascent microvascular networks precedes myogenesis during regeneration, highlighting the primacy of angiogenesis in the healing process. However, the dynamics of angiogenesis in severe or large VML injuries remain less understood.…”

Section: Tissue Regenerationmentioning

confidence: 99%

Biomaterials‐Based Technologies in Skeletal Muscle Tissue Engineering

Luo,

Zhang,

Wan

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

For many clinically prevalent severe injuries, the inherent regenerative capacity of skeletal muscle remains inadequate. Skeletal muscle tissue engineering (SMTE) seeks to meet this clinical demand. With continuous progress in biomedicine and related technologies including micro/nanotechnology and 3D printing, numerous studies have uncovered various intrinsic mechanisms regulating skeletal muscle regeneration and developed tailored biomaterial systems based on these understandings. Here, we discussed the skeletal muscle structure and regeneration process and explored in detail the diverse biomaterial systems derived from various technologies. Biomaterials serve not merely as local niches for cell growth, but also as scaffolds endowed with structural or physicochemical properties that provide tissue regenerative cues such as topographical, electrical, and mechanical signals. They can also act as delivery systems for stem cells and bioactive molecules that have been shown as key participants in endogenous repair cascades. To achieve bench‐to‐bedside translation, we have also summarized the typical effect enabled by biomaterial systems and the potential underlying molecular mechanisms. We hope to provide insights into the roles of biomaterials in SMTE from cellular and molecular perspectives. Finally, we provided perspectives on the advancement of SMTE, for which gene therapy, exosomes, and hybrid biomaterials may hold promise to make important contributions.This article is protected by copyright. All rights reserved

show abstract

“…New blood vessels fuse with existing blood vessels to form a stable vascular network. [43] Remodeling is the last phase of wound healing. During this stage, the complex vascular system contracts and clots, leaving fewer, more robust, and stable vessels.…”

Section: Chronic Wound Pathophysiologymentioning

confidence: 99%

Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds

Hu,

Shan,

Cui

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Acute wounds are converted to chronic wounds due to advanced age and diabetic complications. Nanoenzymes catalyze ROS production to kill bacteria without causing drug resistance, while microneedles (MNs) can break through the skin barrier to deliver drugs effectively. The integration of nanoenzymes into an MNs delivery system can simultaneously improve painless drug delivery and reduce adverse effects. It can also reduce the effective dose of drug sterilization while increasing delivery efficiency and effectively killing wounded bacteria while preventing drug resistance. This paper describes in detail the reasons why nanoenzymes combined with MNs are particularly suitable for the treatment of long‐term inflammation and persistent infections in chronic wounds. The antimicrobial properties of different types of metallic nanoenzymes from previous studies were also analyzed, and the mutual reinforcement of MNs made of different materials combined with nanoenzymes was compared. The pooled results showed that the MNs, through material innovation, were able to both penetrate the scab and deliver nanoenzymes and exert additional anti‐inflammatory and bactericidal effects. The catalytic effect of some of the nanoenzymes can also accelerate the lysis of the MNs or create a cascade reaction against inflammation and infection. However, the issue of increased toxicity associated with skin penetration and clinical translation remains a challenge. This article reviews the latest published results and corresponding challenges associated with the use of MNs combined with nanoenzymes for the treatment of wounds, providing further information for future research.This article is protected by copyright. All rights reserved

show abstract

A comparative study to evaluate the effect of limited access dressing on diabetic ulcers

Cited by 24 publications

References 29 publications

Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells

Development of Physiologically Relevant Skin Organoids from Human Induced Pluripotent Stem Cells

Biomaterials‐Based Technologies in Skeletal Muscle Tissue Engineering

Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds

Contact Info

Product

Resources

About