Pilonidal sinus is chronic condition consisting of a midline pit situated in midgluteal cleft at postanal region usually associated with hairs. Prolong sitting, presence of deep natal cleft, obesity, repeated irritation due to hair, family history may increase the risk of disease. In Ayurvedic science acharya Sushruta mentioned eight types of sinuses as nadivrana. Among these pilonidal sinus can be considered under shalyaj nadivrana (sinus due to foreign body). Ksharasutra is a kind of thread coated with caustic material prepared by ash of certain medicinal plant, minerals, latex etc. Sushruta described ksharasutra in the management of sinuses. A case of pilonidal sinus in 35 years old male patient was thoroughly examined and treated with ksharasutra therapy. Bulk of hairs were expeled out during procedure. Ksharasutra is an ideal procedure to be adopted for the management of sinus track for not only it destroys the fibrous wall of track but also helps in its curettage. A complete cure of disease achieved in 40 days with minimum scar formation. No recurrence and any complain were found in the patient during the follow up period of 8 months. The detail description with susequent photograph will help to understand the procedure.