A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus

Radfar, Lida; Wild, Robert C.; Suresh, Lakshmanan

doi:10.1016/j.tripleo.2007.07.029

Cited by 76 publications

(95 citation statements)

References 42 publications

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“…However, another randomized, double-blind study found no significant differences between tacrolimus and clobetasol in the management of symptomatic OLP (28).…”

Section: Discussionmentioning

confidence: 96%

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Mülayim¹,

Öztürk²,

Uzun³

2016

tdd

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Objectives: Oral lichen planus (OLP) is a chronic inflammatory disorder of unknown etiology that affects the skin and the mucosa, especially the oral mucosa. Several therapeutic agents have been investigated for the treatment of OLP. All agents used in the OLP therapy are palliative. Potent topical steroids are used as the conventional therapy for OLP. Since side-effects or steroid resistance may be encountered, alternative treatments may be necessary. This study aimed to evaluate the efficacy and safety of the topical pimecrolimus in the treatment of OLP. Methods: Seventeen patients with OLP were recruited into this study. Topical pimecrolimus 1% cream was applied twice a day to the affected areas. Patients were followed up for 3-6 months. Photographs of the lesions were taken and analyzed for areas of ulceration, erythema, and reticulation in every clinical examination. Results: We found that topical pimecrolimus 1% cream was an effective treatment for OLP. Two patients could not complete the treatment protocol because of the side effects such as local irritation and nausea. Conclusion: Topical pimecrolimus may be a valuable second treatment choice for patients with steroid-related side-effects or steroid-resistant OLP. However further randomized controlled studies have to be conducted to compare conventional treatment of topical corticosteroid with topical pimecrolimus. Keywords: Oral lichen planus, pimecrolimus, calcineurin inhibitor, treatment, efficacy, safety Öz Abstract Amaç: Oral liken planus (OLP) deri ve mukozaları özellikle de oral mukozayı tutan, etiyolojisi bilinmeyen kronik enflamatuvar bir hastalıktır. OLP tedavisi için birkaç terapötik ajan araştırılmıştır. OLP'nin tedavisinde kullanılan bütün ajanlar palyatif etkilidir. OLP'nin geleneksel tedavisinde potent topikal steroidler kullanılır. Steroidlerin yan etkileri veya steroide direnç ile karşılaşılabileceğinden alternatif tedaviler gerekli olabilir. Bu çalışmada topikal pimekrolimusun OLP'nin tedavisindeki etkinliğini ve güvenirliğini değerlendirmek amaçlandı. Yöntemler: OLP'li 17 hasta çalışmaya alındı. Topikal pimekrolimus %1 krem etkilenmiş bölgelere günde 2 kez uygulandı. Hastalar 3-6 ay süreyle aylık olarak takip edildi. Her kontrolde lezyonların fotoğrafı çekilerek ülserasyon, eritem ve ağ yapısı gibi özellikleri değerlendirildi. Bulgular: Biz OLP'nin tedavisinde topikal %1 pimekrolimusu etkili bulduk. Çalışmaya alınan iki hasta bulantı hissi ve lokal irritasyon gibi yan etkiler nedeni ile tedavi protokolünü tamamlayamadı. Sonuç: Topikal pimekrolimus, steroid ile ilişkili yan etkileri olan hastalarda veya steroide dirençli OLP'nin tedavisinde ikinci seçenek olarak düşünülebilir. Ancak etkinliği tam olarak değerlendirebilmek için OLP'nin geleneksel tedavisi olan topikal steroid ile topikal pimekrolimusun karşılaştırmalı, randomize, kontrollü çalışmaları yapılmalıdır.

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“…However, another randomized, double-blind study found no significant differences between tacrolimus and clobetasol in the management of symptomatic OLP (28).…”

Section: Discussionmentioning

confidence: 96%

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Mülayim¹,

Öztürk²,

Uzun³

2016

tdd

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“…[18] all the participants received a systemic steroid, and in another study [28] the experimental intervention was compared with intralesional steroid. Of the 29 trials using steroid as an active intervention, clobetasol was used in nine trials [4,7,10,11,19,22,23,27,35], triamcinolone in ten trials [4,5,[13][14][15][16]20,28,31,36], flucinolone in two trials [6,8], dexamethasone in two trials [29,34], prednisolone in one trial [18], fluticasone in one trial [9] & betamethasone in two trials [9,20]. Systemic prednisolone was used in one trial [18].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Topical tacrolimus was used in four trials [13,22,23,35], topical pimecrolimus in four trials [15,17,24,33], topical cyclosporine in four trials [3,5,14,16].…”

Section: Study Characteristicsmentioning

confidence: 99%

Medical Management of Oral Lichen Planus: A Systematic Review

Suresh

Krunal²,

Desai³

et al. 2016

JCDR

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“…The ointment must be applied twice daily, but use may be increased to four times daily until remission or symptomatic relief [21][22][23][24][25][26]. There are a few reports about these drugs on labial LP [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Treatmentmentioning

confidence: 99%

Lichen Planus Affecting the Lips

Fern¹,

es²,

Lourenço³

2015

Clin Exp Dermatol Res

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Lichen planus frequently compromises the skin, and the oral mucosa. There is plenty of medical and dental literature about the cutaneous and mucosal lesions of lichen planus, but, comparatively very little has been written specifically about lichen planus compromising the lip vermilion. This structure has a peculiar anatomical and histological architecture, and lichen planus lesions at this site may have some distinct features. This article reviews the recent literature about labial lichen planus in all of its presentations, highlighting some special clinical features that may enable a better diagnosis and differential diagnosis of lip diseases. Besides, personal experience by the authors is added.

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A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus

Cited by 76 publications

References 42 publications

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

The Effectiveness of Topical Pimecrolimus in the Treatment of Oral Lichen Planus

Medical Management of Oral Lichen Planus: A Systematic Review

Lichen Planus Affecting the Lips

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