A comparative trial of ice application versus EMLA cream in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis

Alsantali, Adel

doi:10.2147/ccid.s155023

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Moreover, when ice is used, one study has reported that it resulted in a decrease in discomfort for the patients. 19…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, when ice is used, one study has reported that it resulted in a decrease in discomfort for the patients. 19 Honey is a natural substance used in dentistry for the prevention of caries, treating gingivitis, and treating receding gingiva. 20 In our study, we used a natural sweet-tasting solution such as honey to assess its effect on pain experienced by the patients in administrating dental injections.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of precooling with ethyl chloride versus honey in alleviating intra-oral injection pain in adult patients: A randomized controlled trial

et al. 2023

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Objective: The objective of the study was to assess and compare the effectiveness of precooling with ethyl chloride versus honey in alleviating the pain of dental injection. Methods: About 90 patients were recruited for this randomized controlled trial. In each of the following three groups, 30 patients were allocated: Group 1, precooling with ethyl chloride; Group 2, honey; and Group 3, control. The pain score of patients in each group was measured after injecting the dental local anesthesia using a visual analog scale. Paired t-test and multiple linear regression tests were used for statistical analysis. A p value of ⩽0.05 was considered to be as significant. Results: The mean pain scores of participants residing in different groups were as follows: Group 1: 2.83 ± 1.46, Group 2: 4.33 ± 1.62, and Group 3: 7.80. After administrating ethyl chloride, the majority of the 18 (60%) patients reported to suffer from “mild pain.” Furthermore, in patients who were given honey in Group 2, most of the 21 (70%) patients reported suffering from “moderate pain.” In Group 3 (control) where no anesthetic modality was used, the majority of the 25 (83.33%) patients experienced “severe pain.” A significant difference was noted among the pain scores of three groups ( p = 0.001). Conclusion: The administration of local anesthetic is part of almost all dental procedures. Precooling with ethyl chloride resulted in a greater reduction in pain scores than honey upon administration of local anesthesia injection.

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“…Moreover, when ice is used, one study has reported that it resulted in a decrease in discomfort for the patients. 19…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effectiveness of precooling with ethyl chloride versus honey in alleviating intra-oral injection pain in adult patients: A randomized controlled trial

et al. 2023

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“…This corresponds to a 40% to 50% reduction in pain with ice over EMLA. 46 Another cooling method uses dichlorotetrafluoroethane. In a self-controlled study, 40 patients with palmar HH had their left hand pretreated with dichlorotetrafluoroethane, whereas the right hand was pretreated with an ice pack.…”

Section: Discussionmentioning

confidence: 99%

Techniques to Relieve Pain Associated With Botulinum Injections for Palmar and Plantar Hyperhidrosis

et al. 2021

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BACKGROUND Palmar and plantar hyperhidrosis (HH) is a common condition characterized by excessive sweating of the palms and soles. Botulinum neurotoxin (BTX) is a very effective and safe treatment. However, the associated intense injection pain is a major limiting factor deterring patients from selecting this treatment. OBJECTIVE The aim of this study was to review the numerous techniques used to minimize pain accompanying injections for palmoplantar HH. Additionally, the advantages and limitations of each modality will be discussed. MATERIALS AND METHODS The authors performed a comprehensive literature search in PubMed/MEDLINE, Embase, Cochrane Central, and Google Scholar on randomized controlled trials, cohort studies, and case series on techniques to relieve pain of BTX injections for treatment of palmar and plantar HH. RESULTS Current available techniques in reducing botulinum injection with merits and drawbacks are nerve blocks, Bier blocks, cryoanalgesia, needle-free anesthesia, topical anesthetics, and vibration anesthesia. CONCLUSION Topical anesthesia, ice, and vibration are the safest and most convenient noninvasive available methods to relieve pain associated with botulinum injection. Nerve blocks, Bier block, and needle-free anesthesia provide better anesthesia but are limited by the need for training and equipment.

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“…Similarly, the ethyl chloride spray was more effective than EMLA cream in reducing pain during neurotoxin injections in the forehead [122]. Another series of patients receiving botulinum toxin injections for palmar hyperhidrosis showed the superiority of ice packs over EMLA cream in reducing pain [123]. In contrast, Elibol et al [124] found that both EMLA cream and ice gel pack significantly reduce pain when injecting periocular neurotoxin, but there was no difference between ice and EMLA.…”

Section: Pain Management In Dermatologic Proceduresmentioning

confidence: 99%

Pain Management in Dermatology

Hayoun¹,

Miséry²

2023

Dermatology

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A comparative trial of ice application versus EMLA cream in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis

Cited by 11 publications

References 21 publications

Effectiveness of precooling with ethyl chloride versus honey in alleviating intra-oral injection pain in adult patients: A randomized controlled trial

Effectiveness of precooling with ethyl chloride versus honey in alleviating intra-oral injection pain in adult patients: A randomized controlled trial

Techniques to Relieve Pain Associated With Botulinum Injections for Palmar and Plantar Hyperhidrosis

Pain Management in Dermatology

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