Analysis 1.1. Comparison 1 Longer term AC+BA vs BA, Outcome 1 Withdrawals due to treatment failure/side effects. Analysis 1.2. Comparison 1 Longer term AC+BA vs BA, Outcome 2 No of patients with side effects.. .. .. . Analysis 2.1. Comparison 2 Longer Term AC vs placebo, Outcome 1 Symptom score paired mean difference (Scale-1 to