A comparison between adipose tissue and dental pulp as sources of MSCs for tooth regeneration

Hung, Chia-Nung; Mar, Kwei; Chang, Hao-Chen; Chiang, Yi-Lun; Hu, Huai-Yun; Lai, Chia-Chi; Chu, Rei-Min; Chang, Matthew C.

doi:10.1016/j.biomaterials.2011.05.086

Cited by 67 publications

(43 citation statements)

References 43 publications

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“…SCs could also be a source to regenerate human teeth in the future, as these cells have been successfully used to regenerate living teeth in rabbit extraction sockets (Hung et al, 2011). In some mammals like rodents, rabbits, prairie dogs, and pikas, the teeth can grow throughout life because in these mammals as the pulp cavity remains open permanently.…”

Section: Stem Cells For Bone Regenerationmentioning

confidence: 99%

Oral Tissues as Source for Bone Regeneration in Dental Implantology

Khan¹,

Kleinfeld²,

Winter³

et al. 2012

Tissue Regeneration - From Basic Biology to Clinical Application

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Section: Stem Cells For Bone Regenerationmentioning

confidence: 99%

Oral Tissues as Source for Bone Regeneration in Dental Implantology

Khan¹,

Kleinfeld²,

Winter³

et al. 2012

Tissue Regeneration - From Basic Biology to Clinical Application

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“…DPCs show a greater dentinogenic potential compared to BM-MSCs in the transplantation sites of various animals (4,6,21). However, A-MSCs were also reported to induce dentinogenesis following transplantation with bone morphogenetic protein-2 at a site of tooth extraction in rabbits (22).…”

Section: Discussionmentioning

confidence: 99%

Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells

et al. 2015

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Abstract. Dental pulp cells (DPCs) are a promising source of transplantable cells in regenerative medicine. However, DPCs have not been fully characterized at the molecular level. The aim of the present study was to distinguish DPCs from various source-derived mesenchymal stem cells (MSCs), fibroblasts (FBs) and other cells by the expression of several DPC-characteristic genes. DPCs were isolated from human pulp tissues by the explant method or the enzyme digestion method, and maintained with media containing 10% serum or 7.5% platelet-rich plasma. RNA was isolated from the cells and from dental pulp tissue specimens. The mRNA levels were determined by DNA microarray and quantitative polymerase chain reaction analyses. The msh homeobox 1, msh homeobox 2, T-box 2 and ectonucleoside triphosphate diphosphohydrolase 1 mRNA levels in DPCs were higher than that of the levels identified in the following cell types: MSCs derived from bone marrow, synovium and adipose tissue; and in cells such as FBs, osteoblasts, adipocytes and chondrocytes.The enhanced expression in DPCs was consistently observed irrespective of donor age, tooth type and culture medium. In addition, these genes were expressed at high levels in dental pulp tissue in vivo. In conclusion, this gene set may be useful in the identification and characterization of DPCs in basic studies and pulp cell-based regeneration therapy.

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“…In the same month, scientists compared the use of adipose tissue-derived stem cells and dental pulp stem cells in a non-engineering dental implantation method. Their results clearly demonstrate that both DPSC and ADSC implants grow to form new teeth, and both cell types are characterized by similar proliferation capacity (Hung et al 2011).The other method involves the proliferation of mesenchymal and epithelial stem cells which interact to form new teeth (Yamashiro et al 2006).…”

Section: Tooth Regeneration and Dental Prostheses Held By The Patientmentioning

confidence: 95%

“…The latest research findings (2011) suggest that adipose tissue-derived stem cells (ADSCs) are a more efficient source of stem cells for dentin regeneration. Rabbit ADSCs are also characterized by more intense growth and higher resistance than DPSCs (Hung et al 2011).…”

Section: Regenerative Dentistry With the Use Of Dental Pulp Stem Cellmentioning

confidence: 99%

Stem cells in dentistry – Review of literature

Dziubińska¹,

Jaskólska²,

Przyborowska³

et al. 2013

Polish Journal of Veterinary Sciences

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Stem cells have been successfully isolated from a variety of human and animal tissues, including dental pulp. This achievement marks progress in regenerative dentistry. This article reviews the latest improvements made in regenerative dental medicine with the involvement of stem cells. Although, various types of multipotent somatic cells can be applied in dentistry, two types of cells have been investigated in this review. Dental pulp cells are classified as: DPSCs, SCAPs and SHEDs.The third group includes two types of cell associated with the periodontium: PDL and DFPC. This review aims to systematize basic knowledge about cellular engineering in dentistry.

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A comparison between adipose tissue and dental pulp as sources of MSCs for tooth regeneration

Cited by 67 publications

References 43 publications

Oral Tissues as Source for Bone Regeneration in Dental Implantology

Oral Tissues as Source for Bone Regeneration in Dental Implantology

Characteristic expression of MSX1, MSX2, TBX2 and ENTPD1 in dental pulp cells

Stem cells in dentistry – Review of literature

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