A comparison between criteria for diagnosing atopic eczema in infants

Jøhnke, H; Vach, Werner; Norberg, Lene Annette; Bindslev‐Jensen, Carsten; Høst, Arne; Andersen, Klaus Ejner

doi:10.1111/j.1365-2133.2005.06491.x

Cited by 73 publications

(81 citation statements)

References 27 publications

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“…At birth, data on weight, apgar score, and parental allergic disposition from the included 562 children did not differ from the 435 children who refused participation. At 12 months, prevalence in AD was not different in children lost during the first year, i.e., the 435 non-participating as well as drop-outs were compared with participating children (13). Kjaer et al (12) also found no difference, comparing characteristics of children recruited and those investigated at 6 years follow-up.…”

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confidence: 83%

Food allergy and food sensitization in early childhood: results from the DARC cohort

Eller¹,

Kjær²,

Høst

et al. 2009

Allergy

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153

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Background: The prevalence of food hypersensitivity (FHS) and the relationship with atopic dermatitis (AD) is controversial. The aim of this study was to determine the development of FHS and to correlate this with AD in relation to sensitization and symptoms.Methods: This study combines new data from birth to 18 months of age with previous published results from 3 and 6 years. The Danish Allergy Research Centre cohort, including 562 children, is a unique, population‐based, prospective birth cohort, with clinical examinations at all follow‐ups. All children were examined for the development of AD using Hanifin‐Rajka criteria and for FHS using interviews, skin prick test (SPT), specific immunoglobulin E (IgE), and food challenge according to EAACI guidelines.Results: Twenty children were confirmed with FHS to milk, egg, and peanut. FHS peaked at 18 months (3.6%) and then decreased to 1.2% at 72 months of age. No new cases were found after 3 years. Self‐reporting could only be confirmed in 31% of cases. Among the 122 children with AD, 18 had FHS (14.8%). FHS was IgE‐mediated in 95% of the cases but 16 of 20 children were additionally sensitized to other foods which they tolerated. Children with AD were neither more IgE‐sensitized nor had higher levels of IgE when compared with healthy children but they were more persistently sensitized.Conclusions: Sensitization to foods in young children without food allergy seems to be a normal phenomenon. The discrepancy between sensitization, self‐reported food‐related symptoms and confirmed FHS illustrates the need to perform standardized oral challenges in order to confirm the diagnosis of FHS.

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mentioning

confidence: 83%

Food allergy and food sensitization in early childhood: results from the DARC cohort

Eller¹,

Kjær²,

Høst

et al. 2009

Allergy

Self Cite

153

121

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“…Generally, the diagnosis of AD is based on clinical features combined with the disease history. 4,5 The lack of definitive diagnostic criteria, the wide range of disease intensity and its intermittent course can lead to a questionable diagnosis of AD. 4 During the past decades several sets of diagnostic criteria have been proposed to bring uniformity to the diagnosis of AD.…”

Section: Introductionmentioning

confidence: 99%

Clinical differences between atopic and atopiform dermatitis

Brenninkmeijer

Spuls

Legierse

et al. 2008

Journal of the American Academy of Dermatology

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“…This classification has been a matter of debate, especially with respect to the significance of some minor features in younger children. [19][20][21][22][23] A recent study 24 has demonstrated good agreement between Hanifin-Rajka criteria and other criteria used to diagnose AD at this young age.…”

Section: Commentmentioning

confidence: 99%