A comparison between dopamine-stimulated adenylate cyclase and 3H-SCH 23390 binding in rat striatum

Andersen, Peter Bøgh; Grønvald, Frederik C.; Jansen, Jens Aas

doi:10.1016/0024-3205(85)90028-1

Cited by 140 publications

(50 citation statements)

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“…3-0.35 nM;cf. Sunahara et al, 1991) by three orders of magnitude, this antagonist has also been reported to show a 100-fold higher K B value (40 nM) against the functional (cyclase-stimulating) action of DA than that predicted from its binding constant in broken membrane preparations (Andersen et al, 1985). In addition, 1-100 M of this antagonist was required to antagonize DA-or D 1 -like agonistinduced effect in previous electrophysiological studies using rat brain slices as well as cultured neurons, while still preserving selectivity over D 2 -like antagonists (Pennartz et al, 1992;Schiffmann et al, 1995;Harvey and Lacey, 1996;Nicola et al, 1996).…”

Section: Discussionmentioning

confidence: 94%

Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D₁-like Dopaminergic Receptors

Momiyama

Sim

1996

J. Neurosci.

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The effects of dopamine (DA) on inhibitory transmission onto identified magnocellular neurons were examined in rat basal forebrain slices using whole-cell recording. IPSCs evoked by focal stimulation within basal forebrain nuclei were reversibly blocked by 10 M bicuculline and had a decay time constant of 20.1 Ϯ 0.77 msec in the presence of 6-cyano-7-nitroquinoxalline-2,3-dione (5 M). Bath application of DA reduced the amplitude of IPSCs up to 71.1 Ϯ 1.49% in a concentration-dependent manner between 0.003 and 1 mM (the IC 50 value being 6.6 M), without any effect on the holding current at Ϫ70 mV. DA (10 M) reduced the frequency of miniature IPSCs (mIPSCs) recorded in the presence of TTX (0.5 M), without affecting their mean amplitude, rise time, and decay time constant. Furthermore, the DA-induced effect on mIPSCs remained unaffected by 100 M cadmium, suggesting a presynaptic mechanism independent of calcium influx. SKF 81297, a D 1 -like agonist, mimicked DA-induced effect on evoked IPSCs (IC 50 , 10.9 M), whereas R(Ϫ)-TNPA or (Ϫ)-quinpirole, D 2 -like agonists (30 M), had little or no effect on the amplitude of evoked IPSCs. R(ϩ)-SCH 23390, a D 1 -like antagonist, antagonized the DA-induced effect on IPSCs (K B 0.82 M), whereas S(Ϫ)-eticlopride, a D 2 -like antagonist, showed slight antagonism (K B 7.8 M). Forskolin (10 M) reduced the amplitude of evoked IPSCs to ϳ58% of the control and occluded the inhibitory effect of DA. These findings indicate that DA reduces inhibitory transmission onto magnocellular basal forebrain neurons by activating presynaptic D 1 -like receptors. Key words: dopamine; D 1 receptor; inhibitory postsynaptic currents; magnocellular basal forebrain nuclei; presynaptic modulationMagnocellular basal forebrain (MBF) neurons in the vertical and horizontal limbs of diagonal band of Broca (HDBB), substantia innominata (SI), and nucleus basalis (nB) form the principal source of cholinergic innervation to the cerebral and subcortical brain regions (Rye et al., 1984). Pathophysiologically, degeneration of these cholinergic neurons has been observed in patients with Alzheimer's disease (Coyle et al., 1983;Oyanagi et al., 1989), yet the question of how these cortically projecting neurons can be influenced remains to be clarified. Morphological studies using immunohistochemical techniques have demonstrated that the basal forebrain region receives dopaminergic fibers from the ventral tegmental area, substantia nigra pars compacta, and medial zona interna (Martinez-Murillo et al., 1988;Semba et al., 1988;Eaton et al., 1994). Despite these well documented pathways, the basic effects of dopamine (DA) on synaptic transmission within basal forebrain nuclei are still not well understood. Previous electrophysiological studies using anesthetized rats have shown that neuronal activity is variably inhibited or excited by iontophoretic application of DA in other groups of basal forebrain nuclei, namely the globus pallidus (Bergstrom and Walters, 1984) and ventral pallidum (Napier and Maslowski-Cobuzzi, 1994)...

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Section: Discussionmentioning

confidence: 94%

Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D₁-like Dopaminergic Receptors

Momiyama

Sim

1996

J. Neurosci.

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“…However, one study [49] demonstrated similar increases in reward threshold using quinpirole at doses in the same range as those at which we also observe elevations in BSR threshold, although that study did not test doses higher than 0.066 mg/kg. Apomorphine, an agonist with similar affinity for D2 and D1 receptors [50,51], also increases BSR threshold at low doses (0.01-0.1 mg/kg) and decreases threshold at higher doses (0.3-1.0 mg/kg) [52]. We observe clear increases in BSR threshold following low doses of quinpirole (0.1-0.3 mg/kg) and decreases in threshold at higher doses (1.0-10 mg/kg).…”

Section: Discussionmentioning

confidence: 99%

Prenatal Exposure to Cocaine Increases the Rewarding Potency of Cocaine and Selective Dopaminergic Agonists in Adult Mice

Malanga

Riday

Carlezon

et al. 2008

Biological Psychiatry

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“…The response to SCH 23390 in 5-HT1c oocytes, unlike the responses to the other benzazepines and 5-HT, activated slowly and often required several minutes of exposure to the compound. The rate of association of SCH 23390 with the dopamine D1-receptor is relatively slow (Billard et al, 1984;Andersen et al, 1985;Niznik et al, 1986 However, SKF 77434 (100gM) and SKF 82958 (100pM) (Hyttel, 1983;Hicks et al, 1984;Ohlstein & Berkowitz, 1985;Hess et al, 1986;Bischoff et al, 1986;McQuade et al, 1988;De Keyser et al, 1989 (Sumikawa et al, 1984;Mahan et al, 1990;Sakai et al, 1990). …”

Section: S-hydroxytryptaminementioning

confidence: 99%

Activation of the 5‐HT_1c receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393

Briggs

Pollock

Frail

et al. 1991

British J Pharmacology

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1 A cloned 5-HT1c receptor expressed in Xenopus laevis oocytes was used to characterize the action of four dopamine Di-selective benzazepines at the 5-HT1c receptor. Additionally, the apparent binding of the D1-selective benzazepines to 5-HT1c receptors was measured in the choroid plexus of the pig. 3 The response to SCH 23390 activated slowly and, although the response contained many oscillations characteristic of the activation of the phosphatidylinositol signal transduction system, SCH 23390 rarely elicited the rapid spike-like response seen routinely in response to 5-HT. However, the responses to SKF 38393, SKF 77434, and SKF 82958 were identical in appearance to the response to 5-HT, except that the responses to the benzazepines were smaller. These comparisons were made by applying both a benzazepine and 5-HT to each individual oocyte expressing the cloned 5-HT1c receptor. 4 Consistent with the responses measured in oocytes, SCH 23390 bound stereoselectively to 5-HT1c receptors in the choroid plexus of the pig (K1 = 6.3 nM), and SKF 38393 bound non-stereoselectively with lower affinity (K, = 2.0-2.2 pM). 5 It is concluded that while these benzazepines demonstrate selectivity for the dopamine D1 receptor, they also can act as agonists or partial agonists at the 5-HT1c receptor in situ and as expressed in Xenopus oocytes. The oocyte expression system is useful for studies of the functional pharmacology of these 5-HTic receptors. Information about the pharmacological actions and variations in stereoselectivity among dopamine and 5-HT receptors should be of interest in modelling the interactions of ligands with these G-protein coupled receptors, and in the testing of such models through receptor mutagenesis.

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A comparison between dopamine-stimulated adenylate cyclase and 3H-SCH 23390 binding in rat striatum

Cited by 140 publications

References 11 publications

Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D₁-like Dopaminergic Receptors

Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D₁-like Dopaminergic Receptors

Prenatal Exposure to Cocaine Increases the Rewarding Potency of Cocaine and Selective Dopaminergic Agonists in Adult Mice

Activation of the 5‐HT_1c receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393

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A comparison between dopamine-stimulated adenylate cyclase and 3H-SCH 23390 binding in rat striatum

Cited by 140 publications

References 11 publications

Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D1-like Dopaminergic Receptors

Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D1-like Dopaminergic Receptors

Prenatal Exposure to Cocaine Increases the Rewarding Potency of Cocaine and Selective Dopaminergic Agonists in Adult Mice

Activation of the 5‐HT1c receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393

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Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D₁-like Dopaminergic Receptors

Modulation of Inhibitory Transmission by Dopamine in Rat Basal Forebrain Nuclei: Activation of Presynaptic D₁-like Dopaminergic Receptors

Activation of the 5‐HT_1c receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393