A comparison between gravimetric and in situ spectroscopic methods to measure the sorption of CO2 in a biocompatible polymer

Duarte, Ana Rita C.; Anderson, Lindsey E.; Duarte, Isabel Catarina; Kazarian, Sergei G.

doi:10.1016/j.supflu.2005.04.003

Cited by 43 publications

(24 citation statements)

References 18 publications

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“…Solubility data of flurbiprofen is reported previously [14] as well as the sorption of the carbon dioxide in the polymeric matrix [15,16]. Drug solubility is defined as the amount of solute (drug) that can be dissolved in a certain amount of solvent (supercritical fluid) at certain operational conditions (pressure and temperature).…”

Section: Resultsmentioning

confidence: 99%

Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug delivery

Duarte

Simplı́cio²,

Vega‐González³

et al. 2007

The Journal of Supercritical Fluids

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Supercritical fluid impregnation was tested to prepare a new ophthalmic drug delivery device. Poly(methylmethacrylate-co-ethylhexylacrylateco-ethyleneglycoldimethacrylate), P(MMA-EHA-EGDMA) has been proposed by Mariz [M. Mariz, Preparação de uma lente intra-ocular dotada de um sistema de libertação controlada de fármaco, Master Thesis, Universidade de Coimbra, 1999] as a promising matrix to be used for intraocular delivery of anti-inflammatory drugs used in eye surgery. This matrix was successfully impregnated with flurbiprofen, a non-steroidal anti-inflammatory agent.The success of the impregnation was evaluated by scanning electron microscopy (SEM) analysis and also by in vitro drug release studies. The effect of some operating parameters was evaluated, namely, pressure and contact time. The operating pressure will influence both the solubility of the drug in the supercritical fluid but also the sorption degree of the polymeric matrix in the presence of carbon dioxide. The solubility of the drug in carbon dioxide and the sorption degree are reported in previous studies. A comparison between the batch and the semi-continuous impregnation process is also presented.The supercritical fluid impregnation proved to be feasible for the preparation of a new ophthalmic drug delivery system. The drug release profiles suggest that the drug can be released up to three months, which is a major advantage for the prevention of the inflammatory response after ophthalmic surgery.

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Section: Resultsmentioning

confidence: 99%

Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug delivery

Duarte

Simplı́cio²,

Vega‐González³

et al. 2007

The Journal of Supercritical Fluids

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“…5). The polymer swelling was determined by in-situ spectroscopic techniques and it is described elsewhere [24]. The diffusion length is not significantly alters by the swelling of the polymer.…”

Section: Sorption Of Comentioning

confidence: 99%

“…The use of a quartz-crystal microbalance and a gravimetric method or a barometric method are the most commonly used [11,12]. Transmission IR spectroscopy has also been used to measure the sorption of polymers [13,14,24]. In regards to measurements on polymer swelling, the direct observation of the sample's dimensions is widely used [7].…”

Section: Introductionmentioning

confidence: 99%

Sorption and diffusion of dense carbon dioxide in a biocompatible polymer

Duarte

Martins

Coimbra

et al. 2006

The Journal of Supercritical Fluids

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Mass sorption and diffusion coefficients in one acrylate biocompatible copolymer contacted with supercritical (sc) carbon dioxide are reported. Equilibrium solubility of dense carbon dioxide in poly(methylmethacrylate-co-ethylhexylacrylate-co-ethyleneglycoldimethacrylate) (P(MMA-EHA-EGDMA)) was studied by a gravimetric method in a temperature range from 308 to 323 K and a pressure range from 10.0 to 20.0 MPa. The cross-linked copolymer presented Fickian behavior and Fick's diffusion model was applied to determine the amount of carbon dioxide present and the diffusion coefficients. Diffusion coefficients for the sorption under supercritical conditions and desorption at ambient conditions were determined and compared. Samples of P(MMA-EHA-EGDMA) with different thickness were used for comparison of the maximum sorption degree. Polymerization conditions were also varied in order to evaluate the influence of the molecular weight of the copolymer in the CO 2 sorption process. To investigate the possibility of impregnating this acrylate copolymer with an anti-inflammatory drug, a preliminary experiment was performed.

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“…Duarte et al [140] studied the equilibrium solubility of carbon dioxide in P(MMA-co-EHA-co-EGDMA) by gravimetric method at diff erent temperatures and pressures. Th e crosslinked copolymer showed the Fickian behavior and Fick's diff usion model was applied to determine the amount of carbon dioxide and the diff usion coeffi cients.…”

Section: Crosslinking Monomer(s)mentioning

confidence: 99%

Environmentally‐Friendly Acrylates‐Based Polymer Latices

Shukla¹,

Rai

2014

Advanced Materials for Agriculture, Food, and Environmental Safety

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Acrylic copolymers have achieved prime importance in various avenues of industrial application such as adhesive in packaging and construction, binder and stabilizer in textiles, base coat in leather, topcoat in fl oor polish, pigment binder in paper industries, etc. Acrylic resins are generally known to have superior exterior durability and weather resistance compared to other organic binders/fi lm-formers commonly used in surface coatings. Th e emulsion polymerization of acrylic monomers provides a good combination of performance properties required in fi lm formation. Th ese properties depend on the copolymer composition, particle size, molecular weight, glass transition temperature (Tg), morphology of the latex particles, etc.In this chapter, the reaction components and polymerization process conditions that aff ect the inherent characteristics of the polymers are presented. Th ere is a discussion of the incorporation of comonomer, which would lead to an improvement in the fl exibility of fi lms produced along with adhesion, gloss, hardness, solvent resistance, water resistance, etc. Also, there is a recently developed successful approach for achieving balanced properties which involves the copolymerization of fi lm-forming monomers like acrylate and methacrylates with crosslinkable monomers.

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A comparison between gravimetric and in situ spectroscopic methods to measure the sorption of CO2 in a biocompatible polymer

Cited by 43 publications

References 18 publications

Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug delivery

Supercritical fluid impregnation of a biocompatible polymer for ophthalmic drug delivery

Sorption and diffusion of dense carbon dioxide in a biocompatible polymer

Environmentally‐Friendly Acrylates‐Based Polymer Latices

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