A comparison between partially peeled hulless barley and whole grain hulless barley: beneficial effects on the regulation of serum glucose and the gut microbiota in high-fat diet-induced obese mice

Meng, Yantong; Meng, Qingjia; Li, Chang; Wang, Mengqian; Li, Siqi; Ying, Jian; Zheng, Hao; Bai, Shuqun; Xue, Yong

doi:10.1039/d2fo02098j

Cited by 12 publications

(8 citation statements)

References 66 publications

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“…Whole grain foods have beneficial effects in preventing or mitigating HFD-induced gut microbiota dysbiosis. [31][32][33][34] Firmicutes and Bacteroidetes are two major phyla in the gut that play important roles in regulating host glucose, lipid and cholesterol metabolism. Among these, Firmicutes can inhibit or eliminate the growth of Clostridium perfringens to restore gut homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Whole grain germinated brown rice intake modulates the gut microbiota and alleviates hypertriglyceridemia and hypercholesterolemia in high fat diet-fed mice

Han,

Wu,

Zhu

et al. 2024

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Whole grain germinated brown rice intake modulates the gut microbiota and alleviates hypertriglyceridemia and hypercholesterolemia in high fat diet-fed mice

Han,

Wu,

Zhu

et al. 2024

Food Funct.

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“…Additionally, HFD-induced obesity reduces Ileibacterium spp., and the abundance of these bacteria is negatively correlated with chronic in ammatory diseases such as obesity, atherosclerosis, and aging [40][41][42]. It has been reported that Helicobacter negatively correlates with intestinal tight junction protein expression, which increases after HFD feeding [43].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus acidophilus CICC 6075 Attenuates HFD-induced Obesity by Improving Gut Microbiota Composition and Histidine Biosynthesis

Zhuang,

Yang,

Yang

et al. 2024

Preprint

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This study aimed to investigate the potential anti-obesity efficacy of Lactobacillus acidophilus CICC 6075. The study analyzed metagenomic data from 120 obese and 100 non-obese individuals and found that the abundance of Lactobacillus acidophiluswas significantly higher in normal-weight individuals. High-fat diet (HFD)-induced obese mice were treated with L. acidophilus via daily oral gavage for 12 weeks. After the experiment, the obesity phenotype was assessed, and the fecal 16S rRNA gene sequence was analyzed. Administration of L. acidophilus attenuated excessive weight gain and fat accumulation and maintained the intestinal barrier in HFD-induced obese mice. Sequencing results showed that HFD hindered α and β diversity while reducing the relative abundance of Lactobacillus and norank_f_Muribaculaceaeand significantly increasing the relative abundance of Ilebacterium. L. acidophilus reversed these results and reduced the Firmicutes/Bacteroidetes ratio. Supplementation of L. acidophilusenhanced histidine biosynthesis, inhibited the NF-κB pathway, and significantly reduced the expression levels of inflammatory factors in adipose tissue. These results indicate that L. acidophilus CICC 6075 can significantly improve intestinal microbiota function, promote histidine synthesis, reduce systemic inflammation, and thereby inhibit obesity progression. This suggests that L. acidophilus CICC 6075 may be a good candidate probiotic for preventing obesity.

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“…Past researchers have reported these three genera to be associated with type 2 diabetes mellitus, obesity, SCFAs, and inflammation in mice [ 46 – 48 ]. Recently, researched have confirmed that the relative abundances of the genera norank_f_Muribaculaceae and Ileibacterium were negatively correlated with the area under the curve of oral glucose tolerance test in mice [ 47 ]. In this work, the elevated blood glucose in mice of the T1D and T1D + NaB groups may be attributed to the lower abundance of norank_f_Muribaculaceae , Ileibacterium , and Dubosiella genera compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids

Huang

Wang

et al. 2023

J Transl Med

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Background Diabetic retinopathy (DR) development is associated with disturbances in the gut microbiota and related metabolites. Butyric acid is one of the short-chain fatty acids (SCFAs), which has been found to possess a potential antidiabetic effect. However, whether butyrate has a role in DR remains elusive. This study aimed to investigate the effect and mechanism of sodium butyrate supplementation on DR. Methods C57BL/6J mice were divided into three groups: Control group, diabetic group, and diabetic with butyrate supplementation group. Type 1 diabetic mouse model was induced by streptozotocin. Sodium butyrate was administered by gavage to the experimental group daily for 12 weeks. Optic coherence tomography, hematoxylin–eosin, and immunostaining of whole-mount retina were used to value the changes in retinal structure. Electroretinography was performed to assess the retinal visual function. The tight junction proteins in intestinal tissue were evaluated using immunohistochemistry. 16S rRNA sequencing and LC–MS/MS were performed to determine the alteration and correlation of the gut microbiota and systemic SCFAs. Results Butyrate decreased blood glucose, food, and water consumption. Meanwhile, it alleviated retinal thinning and activated microglial cells but improved electroretinography visual function. Additionally, butyrate effectively enhanced the expression of ZO-1 and Occludin proteins in the small intestine. Crucially, only butyric acid, 4-methylvaleric acid, and caproic acid were significantly decreased in the plasma of diabetic mice and improved after butyrate supplementation. The deeper correlation analysis revealed nine genera strongly positively or negatively correlated with the above three SCFAs. Of note, all three positively correlated genera, including norank_f_Muribaculaceae, Ileibacterium, and Dubosiella, were significantly decreased in the diabetic mice with or without butyrate treatment. Interestingly, among the six negatively correlated genera, Escherichia-Shigella and Enterococcus were increased, while Lactobacillus, Bifidobacterium, Lachnospiraceae_NK4A136_group, and unclassified_f_Lachnospiraceae were decreased after butyrate supplementation. Conclusion Together, these findings demonstrate the microbiota regulating and diabetic therapeutic effects of butyrate, which can be used as a potential food supplement alternative to DR medicine.

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A comparison between partially peeled hulless barley and whole grain hulless barley: beneficial effects on the regulation of serum glucose and the gut microbiota in high-fat diet-induced obese mice

Abstract: Though hypoglycemic effect of whole grain hulless barley (Hordeum vulgare L.) was documented, whether glucose metabolism would be improved by hulless barley with moderate peeling is still unclear. The purpose...

Cited by 12 publications

References 66 publications

Whole grain germinated brown rice intake modulates the gut microbiota and alleviates hypertriglyceridemia and hypercholesterolemia in high fat diet-fed mice

Whole grain germinated brown rice intake modulates the gut microbiota and alleviates hypertriglyceridemia and hypercholesterolemia in high fat diet-fed mice

Lactobacillus acidophilus CICC 6075 Attenuates HFD-induced Obesity by Improving Gut Microbiota Composition and Histidine Biosynthesis

Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids

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