A comparison between post-operative analgesia after intrathecal nalbuphine with bupivacaine and intrathecal fentanyl with bupivacaine after cesarean section

Goma, Hala M.; Mohamed, Nashwa Nabil; Zoheir, Heba Allah; Ali, Mohamad

doi:10.1016/j.egja.2014.03.008

Cited by 47 publications

(78 citation statements)

References 9 publications

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“…Similarly, in studies conducted by Mukherjee et al, (15) Sagar et al, (18) Shakooh et al, (19) the time of onset of grade III motor blockade was found to be 5.6±0.53 minutes, 5.9±0.4 minutes and 4.47±1.46 minutes, respectively. In studies conducted by Mukherjee et al, (15) H.M Gomaa et al, (14) Sagar et al, (18) the duration of motor blockade was found to be 141.0±5.83 minutes, 125.33±5.71 minutes and 142.2±6.7 minutes respectively, which are comparable with our observation.…”

Section: Discussionsupporting

confidence: 82%

“…In a study conducted by Mukherjee et al in 2011 (15) with 0.8 mg intrathecal Nalbuphine, the time for sensory regression to S1 was found to be 153.3±6.05 min. In another study conducted by HM Gomaa et al in 2014, (14) the time for sensory regression to S1 was 123.00±5.66 min. While Patwa et al (16) found the sensory regression to S1 to be 98.16±9.86 min.…”

Section: Discussionmentioning

confidence: 99%

“…In another study Marzieh-Beigom Khezri et al (11) found motor regression time to Bromage 0 was 118±14.65 minutes, which is significantly less than our study. In a study conducted by H. M. Gomaa et al (14) with intrathecal Nalbuphine, the time of onset of grade III motor blockade was found to be 5.72±0.17 minutes. Similarly, in studies conducted by Mukherjee et al, (15) Sagar et al, (18) Shakooh et al, (19) the time of onset of grade III motor blockade was found to be 5.6±0.53 minutes, 5.9±0.4 minutes and 4.47±1.46 minutes, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…The time to onset of sensory blockade in the group injected with 0.8 mg of Nalbuphine was found to be 3.3±0.8 min., which was comparable with our study. In a study conducted by Gomaa et al in 2014, (14) comparing 0.5 mL of 2 mcg fentanyl with 0.5 mL of 0.8 mg nalbuphine with 2 mL of 0.5% hyperbaric bupivacaine. The time of onset of sensory block was found to be 1.64±0.09 min.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Intrathecal Nalbuphine and Magnesium Sulphate Used as Adjuvants With Bupivacaine in Spinal Anaesthesia for Lower Abdominal Surgery: A Comparison

Choudhury¹,

Pathak²,

Chauhan³

et al. 2016

jemds

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Intrathecal Nalbuphine and Magnesium Sulphate Used as Adjuvants With Bupivacaine in Spinal Anaesthesia for Lower Abdominal Surgery: A Comparison

Choudhury¹,

Pathak²,

Chauhan³

et al. 2016

jemds

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“…7 It prolongs the duration of analgesia without affecting the motor and autonomic nervous system. 8 The most common side effects with the use of opioids include pruritis, respiratory depression, nausea, vomiting, urine retention and sedation. 9 Various animal studies have also been conducted to confirm that Nalbuphine was not neurotoxic.…”

Section: Discussionmentioning

confidence: 99%

Efficiency of nalbuphine as an adjuvant to bupivancaine in lower limb orthopaedic surgery-a prospective study

Gupta¹,

Gupta²,

Neeraj

2017

Int J Res Med Sci

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INTRODUCTIONSpinal anaesthesia is a well embraced technique for performing lower limb orthopaedic surgeries. It is simpler to perform with rapid onset of action and profound muscle relaxation. Spinal anaesthesia allows for lower drug dosage and lower incidence of failed block.1,2 Every coin has two sides. Spinal anaesthesia has a shorter duration of action and early arising postoperative pain due to which various adjuvant need to be added and their roles are being evaluated in various studies. Intrathecal administration of adjuvant drugs to local anaesthesia improves quality and duration of spinal blockage and also prolongs postoperative analgesia. Moreover, the dose and amount of local anaesthetic drugs are also reduced during subarachnoid block. 3Intrathecal opioids act synergistically with local anesthetics and thus intensifying the sensory block without having any effect ABSTRACT Background: Spinal Anaesthesia is a well-known technique of performing lower limb orthopaedic surgeries. It has a shorter duration of action and early arising postoperative pain due to which various adjuvant needs to be added and their roles are being evaluated in various studies. Intrathecal opioids act synergistically with local anaesthetics and thus intensifying the sensory block without having any effect on sympathetic blockage. The main aim of present study is to investigate and evaluate the effectiveness of intrathecal nalbuphine (preservative free) as an adjuvant and also the efficacy of nalbuphine for postoperative analgesia and its complications if there are any. Methods: A total of 60 patients were included in this study belonging to ASA I and ASA II score with normal coagulation profile. Patients were randomly divided into 2 groups of 30 patients each. Group I receiving 3 ml of hyperbaric bupivacaine 0.5%+1.0mgm of nalbuphine (preservative free) injection made in 0.5 ml normal saline intrathecally. Group II received 3 ml of hyperbaric bupivacaine 0.5%+0.5 ml injection Normal saline intrathecally. The following criteria were noted. The onset of sensory blockade and complete motor blockade highest level of sensory blockade, duration of sensory blockade, duration of motor and duration of effective analgesia were recorded. Any hemodynamic alterations were also noted. Results: The mean time for the onset of sensory blockage was 56 sec in Group I and 59 sec in Group II (control). The difference were statistically insignificant (p>0.05). The mean onset of motor blockage was 106 sec in Group I and 208 sec in Group II (control). The difference was statically insignificant. The peak onset time in Group I and Group II was 372 sec and 220 sec respectively (p>0.05). Two segment regression times for sensory blockage was prolonged in Group I (118.20±8.56 min) compared to Group II (104.56±15.20 mins). Conclusions: The duration of postoperative analgesia was 6-8 hours in Group I compared to 3-4 hours in Group II (p value= 0.0001, statistically significant).

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Nalbuphine as an adjuvant to 0.25% levobupivacaine in ultrasound-guided supraclavicular block provided prolonged sensory block and similar motor block durations (RCT)

Abdelhamid

Omar

2018

J Anesth

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A comparison between post-operative analgesia after intrathecal nalbuphine with bupivacaine and intrathecal fentanyl with bupivacaine after cesarean section

Cited by 47 publications

References 9 publications

Effect of Intrathecal Nalbuphine and Magnesium Sulphate Used as Adjuvants With Bupivacaine in Spinal Anaesthesia for Lower Abdominal Surgery: A Comparison

Effect of Intrathecal Nalbuphine and Magnesium Sulphate Used as Adjuvants With Bupivacaine in Spinal Anaesthesia for Lower Abdominal Surgery: A Comparison

Efficiency of nalbuphine as an adjuvant to bupivancaine in lower limb orthopaedic surgery-a prospective study

Nalbuphine as an adjuvant to 0.25% levobupivacaine in ultrasound-guided supraclavicular block provided prolonged sensory block and similar motor block durations (RCT)

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