Auxetic mechanical metamaterials are a class of architected materials that exhibit the exotic characteristic of a negative Poisson's ratio (NPR). This work aimed to evaluated the NPR potential of differently-oriented architected structures consisted of hinged triangular prisms connected by their corners. By implementing kinematic models of the systems, we assessed the deformation mechanism of the idealized structure: the models allow to investigate some geometrical variants of the rotating polyhedrons with different orientation schemes, which are at 45° to each other. The computational results showed that the Poisson's ratio (PR) of the system varies from -0.3 up to -1.3, depending both on geometrical parameters of the polyhedral elements and on the orientation of the unit cells. To further investigate the deformation behavior of the metamaterial, we designed prismatic architectures with chiral connections between the rotating units, which were validated using finite element (FE) method. The numerical simulations reveal a remarkably different auxetic properties between these designs, with a PR ranging between -0.08 and -0.70. Hence, physical models were additively manufactured in Onyx material and experimentally tested under uniaxial compression, showing an excellent agreement with the numerical predictions. Our results demonstrate the highly tunable NPR ability of such mechanical metamaterials, with a possible application in the biomedical field.