A comparison for the effects of raw, smoked, and smoked and brined areca nut extracts on the immune and inflammatory responses in the Kunming mice

Ke, Li; Wang, Chuanhua; Zhao, Ziwei; Wu, Zhongqin; Wu, Zhongkun; Tian, Xing; Xiao, Yu; Li, Zongjun; Wang, Yuanliang

doi:10.1111/jfbc.13319

Cited by 10 publications

(12 citation statements)

References 30 publications

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“…Interestingly, the inhibitory effect on BW in the MAF group was lower than that in the FT and LAF groups, which may indicate that the inhibitory effects of AFTs on weight gain were suppressed within a certain mixing ratio and disappeared with a larger mixing ratio, and hence, the effect on weight in the HAF group was significant among the treatment groups. The effect of FT on the inhibition of obesity is well recognized (Liu et al, 2019), and our previous research also showed that areca nut could inhibit weight gain (Li, et al, 2020); these findings were also consistent with our results. The amount of food intake in the HAF group was the highest among all groups, but its weight gain and final weight were the lowest among all groups.…”

Section: Discussionsupporting

confidence: 92%

“…In general, with an increase in the areca nut content, the inhibitory effects on TBA and FFA levels in the HAF group were more obvious. It is remarkable that FFA could induce insulin resistance and glucose metabolism dysfunction in the body and cause health problems (Li, et al, 2020). The HAF group showed the best regulatory effect on FFA, which obviously indicated the alleviation of insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

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Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

Zhou

Tian

et al. 2021

J Food Biochem

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Areca nut and Fuzhuan brick tea, a type of natural plant products, have obvious effects of fat reduction and weight loss; however, there is no report on their synergistic effect. This study investigated the effects of Fuzhuan brick tea supplemented with different concentrations of areca nut (5% (LAF), 10% (MAF), and 20% (HAF)) on serum and gut microbiota in Kunming (KM) mice. The results showed that Fuzhuan brick tea supplemented with areca nuts (AFTs) could reduce weight, prevent the accumulation of fat, inhibit the increase in the levels of serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, blood glucose, free fatty acid, insulin, and total bile acid, alleviate the decrease in high-density lipoprotein cholesterol level, and regulate the composition of gut microbiota by high-fat diet intervention. The HAF group with 20% areca nut content showed the best effect. These results could provide a novel approach to prevent obesity and hyperlipidemia. Practical applicationsConsumption of areca nut and tea is widespread in Asia and other regions. As a controversial raw material, the damage due to areca nut to oral mucosa health has often

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

Zhou

Tian

et al. 2021

J Food Biochem

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“…In our previous study, two kinds of polyphenols, catechin and proanthocyanidin B1 were found [ 23 ]. To further investigate the antioxidant activity of ANP, we used a macrophage-like cell line, RAW264.7, which is a cellular model to study antioxidant and anti-inflammatory activities at the cellular level.…”

Section: Discussionmentioning

confidence: 99%

“…The total polyphenol contents were estimated at 80% by the Folin-Ciocalteu method [ 22 ]. In previous studies, the two kinds of polyphenol compositions of areca nuts were catechins (2060.44 ± 18.24 μg/mL) and proanthocyanidin B1 (2510.18 ± 62.40 μg/mL) [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

In Vitro Antioxidant Activity of Areca Nut Polyphenol Extracts on RAW264.7 Cells

Zou

et al. 2022

Foods

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Chewing areca nuts is a popular hobby in the Asian region, and areca nuts are rich in polyphenols, although some alkaloids are included. In this study, we explored the antioxidant activity of areca nut polyphenols (ANP) in lipopolysaccharides (LPS)-stimulated RAW264.7 cells. The results revealed that ANP reduced the level of reactive oxygen species (ROS) in LPS-stimulated RAW264.7 cells and enhanced the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1). RNA-seq analysis showed that ANP down-regulated the transcription of genes related to the cancer pathway at 160 μg/mL, and the inflammatory pathway as well as viral infection pathway at 320 μg/mL. The cellular signaling analysis further revealed that the expressions of these genes were regulated by the mitogen-activated protein kinase (MAPK) pathway, and ANP downregulated the activation of the MAPK signaling pathway stimulated by LPS. Collectively, our findings showed that ANP inhibited the MAPK pathway and activated the Nrf2/HO-1 antioxidant pathways to reduce ROS generation induced by LPS.

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“…It is also reported that AN chewing habit has detrimental effects on the metabolic system [ 12 ], increasing the risk of obesity [ 13 ], hyperglycemia [ 14 ], and, causing hypothyroidism [ 15 ] and vitamin D deficiency [ 16 ]. Chronic AN consumption also interferes with the immune system [ 17 , 18 , 19 ], causing suppression of T-cell activity and decreased release of cytokines [ 20 ]. AN usage also increases cardiovascular disease rate, including heart attack, coronary artery diseases [ 21 , 22 ] and paroxysmal supraventricular tachycardia (PSVT) [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Role of Host Microbiome in Areca Nut-Associated Carcinogenesis and Addiction

et al. 2022

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Areca nut (AN) is widely consumed all over the world, bringing great harm to human health and economy. Individuals with AN chewing are at high risk of cardiovascular disease and impaired immune system and metabolic system. Despite a growing number of studies having reported on the adverse effects brought by AN chewing, the exact mechanism of it is limited and the need for additional exploration remains. In recent years, the interaction between microorganisms, especially intestinal microorganism and host, has been extensively studied. AN chewing might disrupt the oral and intestinal microbiota communities through direct connect with the microbes it contains, altering PH, oxygen of oral and intestinal microenvironment, and disturbing the immune homeostasis. These mechanisms provide insights into the interplay between areca nut and host microbiota. Emerging studies have proposed that bidirectional interaction between polyphenols and intestinal microbes might play a potential role in the divergence of polyphenol, extracted from AN, among individuals with or without AN-induced cancer development and progression. Although some AN chewers have been aware of the harmful effects brought by AN, they cannot abolish this habit because of the addiction of AN. Increasing studies have tried to revealed that gut microbiota might influence the onset/development of addictive behaviors. Altogether, this review summarizes the possible reasons for the disturbance of host microbiota caused by areca nut chewing and clarifies the complex interaction between human microbiome and major constituents and the addiction and carcinogenicity of AN, tempting to provide novel insights into the development and utilization of it, and to control the adverse consequences caused by AN chewing.

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A comparison for the effects of raw, smoked, and smoked and brined areca nut extracts on the immune and inflammatory responses in the Kunming mice

Cited by 10 publications

References 30 publications

Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

Fuzhuan brick tea supplemented with areca nuts: Effects on serum and gut microbiota in mice

In Vitro Antioxidant Activity of Areca Nut Polyphenol Extracts on RAW264.7 Cells

Potential Role of Host Microbiome in Areca Nut-Associated Carcinogenesis and Addiction

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