A comparison of an antibacterial sandwich dressing vs dressing containing silver

Abstract

The purpose of this study was to compare the efficacy of dressings containing octenidine vs. dressings containing silver in the wound healing in the course of a chronic venous disease. There were two groups of 40 patients who met the inclusion criteria and who did not meet the exclusion criteria. The patients were randomly assigned into the groups (envelope method). The first, "O group" was treated with octenidine-based dressings. The second, "S group" was treated with silver dressings. The study lasted for 56 days. All patients in the research were treated with medical compression stockings with cotton understockings. Microbiological eradication was observed on the 28th day of the study among 33% of patients in the treatment group vs. 6% in control group. On the 56th day of the treatment, these percentages equalled 72% and 35%. The rate of healing was faster in the 0 group than in the S group. In the wounds <10 cm(2) it was faster by 1.35 cm(2)/week and in wounds >10 cm(2) it equalled 3.44 cm(2). The reduction of pain level was 37.5% higher in the O group, in contrast with the S group. One change of a dressing in the O group led to a 0.06 cm(2) greater wound size reduction and in the case of wounds >10 cm(2) to 0.29 cm(2) reduction compared with the S group. The presented results indicate that the efficacy of dressings containing octenidine is higher compared to silver dressings.

Silver dressings for the healing of venous leg ulcer

“…Therefore, 9 RCTs were included in qualitative synthesis, of which data in 1 RCT was unable to be integrated. Finally, 8 RCTs were included in this study [ 8 , 13 , 21 , 22 , 24 – 27 ] (Fig. 1 ).…”

“…A total of 1057 participants among the 8 RCTs were included in this study. The RCTs were conducted in France (n = 2), [ 13 , 21 ] Britain (n = 1), [ 8 ] Poland (n = 1), [ 22 ] Australia (n = 1), [ 23 ] China (n = 2), [ 25 , 26 ] and 1 [ 24 ] was a multinational trial in 5 Western countries. Details of the baseline characteristics of each study are provided in Table 1 .…”

“…Sixteen (53.3%) and 19 (63.3%) patients given the test and control dressing respectively had a history of ulceration. The research conducted by Krasowski et al [ 22 ] required the ABPI of participants above 0.8 and the leg wounds, which were 2 to 200 cm 2 , did not heal for at least 6 weeks. The requirements of Lazareth et al [ 13 ] for ABPI of participants were consistent with Krasawski et al In their study, leg ulcers were present for almost 11 months on average (median 9.0 months) and 65% were recurrent.…”

“…Two [ 13 , 21 ] and 3 [ 13 , 21 , 24 ] studies reported the effect on absolute and relative wound size changes, respectively. Five studies [ 13 , 22 – 24 , 26 ] analyzed the effect on wound healing rate. Four studies had a sample size of 60 [ 21 , 26 ] or 80, [ 22 , 25 ] while the other 4 studies had participants ranging from 102 through 281.…”

Narastająca lekooporność Acinetobacter baumannii – rosnące zagrożenie dla oddziałów oparzeniowych

“…Niezależnie od wrażliwości szczepu, oktenidyna wykazywała silne działanie przeciwbiofilmowe na wszystkich badanych powierzchniach [48]. Klinicznie potwierdzono także przewagę opatrunków z oktenidyną nad opatrunkami zawierającymi srebro [49].…”