A comparison of anti-type II collagen antibody titres and isotype profiles in pregnant and virgin DBA/1 mice with collagen-induced arthritis

Williams, Richard O.; Whyte, A.

doi:10.1016/0165-0378(89)90014-4

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…Similar findings in rats with adjuvant arthritis and mice with proteoglycan-induced arthritis have been reported [18,19]. It is significant that pregnancy-induced remission in CIA is associated with a reduction in circulating levels of all type II collagen-specific isotypes of IgG, indicating a profound immunomodulatory effect [20].…”

Section: The Role Of Female Sex Hormonessupporting

confidence: 84%

What Have We Learned about the Pathogenesis of Rheumatoid Arthritis from TNF-Targeted Therapy?

Williams

2012

ISRN Immunology

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Studies of cytokine regulation in rheumatoid arthritis led to the development of TNFαinhibitors which are now used for a number of indications, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, psoriatic arthritis, and ankylosing spondylitis. The widespread use of biologics in the clinic offers unique opportunities for probing disease pathogenesis and this paper provides an overview of rheumatoid arthritis, with a particular emphasis on the impact of anti-TNFαtherapy on pathogenetic mechanisms. An overview is also provided on the most commonly used animal models that mimic RA, including adjuvant-induced arthritis, collagen-induced arthritis, TNFα-transgenic mice, and the K/BxN and SKG models. These models have led to significant discoveries relating to the importance of pro-inflammatory cytokines in the pathogenesis of rheumatoid arthritis, resulting from disregulation of the normally finely tuned balance of pro- and anti-inflammatory cytokine signalling. In addition, experimental evidence is discussed suggesting how genetic and environmental factors can contribute to disease susceptibility. The role of effector and regulatory T cells is discussed in the light of the relatively disappointing therapeutic effects of T cell modifying agents such as anti-CD4 antibody and cyclosporin. It is concluded that comprehensive analyses of mechanisms of action of biologics and other drugs entering the clinic will be essential to optimise therapy, with the ultimate aim of providing a cure.

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Section: The Role Of Female Sex Hormonessupporting

confidence: 84%