A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005

Moulin, Gérard; Cavalié, Philippe; Pellanne, I.; Chevance, Anne; Laval, A.; Millemann, Yves; Colin, P.; Chauvin, Claire

doi:10.1093/jac/dkn213

Cited by 85 publications

(56 citation statements)

References 8 publications

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“…ceftiofur in animals and cefotaxime in humans, both belonging to the class of 3 rd generation cephalosporin drugs), most major classes of drugs are used in both human and veterinary medicine (Moulin et al, 2008). Classes of drugs solely used in veterinary medicine include feed additives such as ionophores, quinoxalines or bambermycins (Collignon et al, 2009).…”

Section: Overlap Of Antimicrobials Used In Veterinary and Human Medicinementioning

confidence: 99%

“…Classes of drugs solely used in veterinary medicine include feed additives such as ionophores, quinoxalines or bambermycins (Collignon et al, 2009). When studying antimicrobial consumption in France, Moulin et al (2008) found that four antimicrobial classes were accounting for 80% of sales in veterinary medicine (tetracyclines, sulphonamides/trimethoprim, beta-lactams and aminoglycosides) whereas beta-lactam antimicrobials dominated in human medicine (accounting for more than 50% of the total consumption). As an example of overlapping use, WHO Criteria:…”

Section: Overlap Of Antimicrobials Used In Veterinary and Human Medicinementioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Susceptibility of FecalEscherichia coliIsolates in Dairy Cows Following Systemic Treatment with Ceftiofur or Penicillin

Mann

Siler

Jordan

et al. 2011

Foodborne Pathogens and Disease

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Section: Overlap Of Antimicrobials Used In Veterinary and Human Medicinementioning

confidence: 99%

Section: Overlap Of Antimicrobials Used In Veterinary and Human Medicinementioning

confidence: 99%

Antimicrobial Susceptibility of FecalEscherichia coliIsolates in Dairy Cows Following Systemic Treatment with Ceftiofur or Penicillin

Mann

Siler

Jordan

et al. 2011

Foodborne Pathogens and Disease

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“…Tetracycline resistance genes are often located on mobile elements such as plasmids, transposons and/or conjugative transposons, which can be transferred between bacterial species (Chopra and Roberts, 2001;Michalova et al, 2004). Studies on tetracycline resistance mechanisms are justified by data about tetracyclines being the far most frequently used antimicrobials in the EU (Schwarz and Chaslus-Dancla, 2001;Moulin et al, 2008;EMA, 2014).…”

mentioning

confidence: 99%

Conjugative IncF and IncI1 plasmids with tet(A) and class 1 integron conferring multidrug resistance in F18+ porcine enterotoxigenic E. coli

Szmolka

Lestár

Pászti

et al. 2015

Acta Veterinaria Hungarica

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Enterotoxigenic E. coli (ETEC) bacteria frequently cause watery diarrhoea in newborn and weaned pigs. Plasmids carrying genes of different enterotoxins and fimbrial adhesins, as well as plasmids conferring antimicrobial resistance are of prime importance in the epidemiology and pathogenesis of ETEC. Recent studies have revealed the significance of the porcine ETEC plasmid pTC, carrying tetracycline resistance gene tet(B) with enterotoxin genes. In contrast, the role of tet(A) plasmids in transferring resistance of porcine ETEC is less understood. The objective of the present study was to provide a comparative analysis of antimicrobial resistance and virulence gene profiles of porcine post-weaning ETEC strains representing pork-producing areas in Central Europe and in the USA, with special attention to plasmids carrying the tet(A) gene. Antimicrobial resistance phenotypes and genotypes of 87 porcine ETEC strains isolated from cases of postweaning diarrhoea in Austria, the Czech Republic, Hungary and the Midwest USA was determined by disk diffusion and by PCR. Central European strains carrying tet(A) or tet(B) were further subjected to molecular characterisation of their tet plasmids. Results indicated that > 90% of the ETEC strains shared a common multidrug resistant (MDR) pattern of sulphamethoxazole (91%), tetracycline (84%) and streptomycin (80%) resistance. Tetracycline resistance was most frequently determined by the tet(B) gene (38%), while tet(A) was identified in 26% of all isolates with wide ranges for both tet gene types between some countries and with class 1 integrons and resistance genes co-transferred by conjugation. The virulence gene profiles included enterotoxin genes (lt, sta and/or stb), as well as adhesin genes (k88/f4, f18). Characterisation of two representative tet(A) plasmids of porcine F18 + ETEC from Central Europe revealed that the IncF plasmid (pES11732) of the Czech strain (~120 kb) carried tet(A) in association with catA1 for chloramphenicol resistance. The IncI1 plasmid (pES2172) of the Hungarian # Present address: Ceva-Phylaxia, Szállás u.

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“…In addition to antimicrobial activity, some actinobacterial bacteriocins and their semisynthetic derivatives also exhibit anti-inflammatory [19][20][21], anti-allergic [20], antitumour [22][23][24] and antinociceptive activities [25,26], and may also act in blood pressure regulation [19,27]. Some of these peptides have already found clinical applications, such as thiostrepton, a thiopeptide used in dermatologic ointment for veterinary use [28], and others are in stages of pre-clinical and clinical trials, such as NAI-107, NAI-112 [29] and lancovutide/duramycin (https://clinicaltrials.gov/ct2/show/study/ NCT00671736?term=Lancovutide&rank=1; accessed September 17,2016), which reinforces the great potential of practical application of bacteriocins produced by Actinobacteria.…”

Section: Bacteriocins Produced By Actinobacteriamentioning

confidence: 99%

Lantibiotics produced by Actinobacteria and their potential applications (a review)

Gomes¹,

Duarte²,

Bastos³

2017

Microbiology

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The phylum Actinobacteria, which comprises a great variety of Gram-positive bacteria with a high G+C content in their genomes, is known for its large production of bioactive compounds, including those with antimicrobial activity. Among the antimicrobials, bacteriocins, ribosomally synthesized peptides, represent an important arsenal of potential new drugs to face the increasing prevalence of resistance to antibiotics among microbial pathogens. The actinobacterial bacteriocins form a heterogeneous group of substances that is difficult to adapt to most proposed classification schemes. However, recent updates have accommodated efficiently the diversity of bacteriocins produced by this phylum. Among the bacteriocins, the lantibiotics represent a source of new antimicrobials to control infections caused mainly by Gram-positive bacteria and with a low propensity for resistance development. Moreover, some of these compounds have additional biological properties, exhibiting activity against viruses and tumour cells and having also potential to be used in blood pressure or inflammation control and in pain relief. Thus, lantibiotics already described in Actinobacteria exhibit potential practical applications in medical settings, food industry and agriculture, with examples at different stages of pre-clinical and clinical trials.

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A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005

Abstract: The same antimicrobial drugs were used in human and veterinary medicines but the quantitative patterns of use were different. Expression of antimicrobial usage is a key point to address when comparing usage trends.

Cited by 85 publications

References 8 publications

Antimicrobial Susceptibility of FecalEscherichia coliIsolates in Dairy Cows Following Systemic Treatment with Ceftiofur or Penicillin

Antimicrobial Susceptibility of FecalEscherichia coliIsolates in Dairy Cows Following Systemic Treatment with Ceftiofur or Penicillin

Conjugative IncF and IncI1 plasmids with tet(A) and class 1 integron conferring multidrug resistance in F18+ porcine enterotoxigenic E. coli

Lantibiotics produced by Actinobacteria and their potential applications (a review)

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