A comparison of bioactive aqueous extracts and polysaccharide fractions from roots of wild and cultivated Cochlospermum tinctorium A. Rich

Inngjerdingen, Kari Tvete; Ballo, Ngolo; Zhang, Bing-Zhao; Malterud, Karl Egil; Michaelsen, Terje E.; Diallo, Drissa; Paulsen, Berit Smestad

doi:10.1016/j.phytochem.2013.03.012

Cited by 24 publications

(13 citation statements)

References 35 publications

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“…Bioactive polysaccharides containing abundant uronic acid contents have been isolated from several plants and algaes, including Cochlospermum tinctorium A. Rich, A. membranaceus and Sargassum plagiophyllum (Inngjerdingen et al 2013;Li et al 2014a, b, c;Suresh et al 2013). These results showed that the antitumor activity of APS2 with 48.87 % galacturonic acid was stronger than APS1 without galacturonic acid, and it is in accordance with previous results.…”

Section: Antitumor Activitysupporting

confidence: 87%

“…These results showed that the inhibition ratios of APS2 with Mw of 184.1 kDa were observably higher than that of APS1 with Mw of 125.4 kDa at the same concentration. Although the mechanism behind the biological activity of polysaccharides is not fully known, the monosaccharide composition also has an important influence on the antitumor activity of polysaccharides (Inngjerdingen et al 2013;Li et al 2014a, b, c;Suresh et al 2013). Bioactive polysaccharides containing abundant uronic acid contents have been isolated from several plants and algaes, including Cochlospermum tinctorium A.…”

Section: Antitumor Activitymentioning

confidence: 99%

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Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Wang

Umair

et al. 2016

J Food Sci Technol

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Artemisia selengensis Turcz (AST) is a perennial herb with therapeutic and economic applications in China. The effects of ultrasound-assisted extraction (UAE) parameters upon extraction yield (EY%), antioxidant and antitumor activities of the polysaccharides extracts were studied by using a factorial design and response surface methodology. The optimal conditions determined were as: ultrasonic power 146 W, extraction time 14.5 min. and extraction temperature 60°C. The average molecular weights of two homogeneous polysaccharides (APS1 and APS2) purified by DEAE cellulose-52 and Sephadex G-100 column chromatography were 125.4 and 184.1 kDa, respectively. Monosaccharide analysis showed that APS1 and APS2 were composed of five common monomers i.e., galactose, mannose, arabinose, xylose and rhamnose and one different monomer glucose and galacturonic acid respectively, with a most abundant part in molar % of APS1 and APS2 were glucose (83.01 %) and galacturonic acid (48.87 %) while least were xylose (0.80 %) and mannose (1.73 %) respectively. The antioxidant properties were determined by evaluating DPPH, hydroxyl radical scavenging activity and reducing power which indicated both APS1 and APS2 showed strong scavenging activities and anticancer activities on HT-29, BGC823 and antitumor activity on HepG-2. As UAE improved the polysaccharides yield than CSE, meanwhile, no significant difference of polysaccharides chemical compositions. Therefore, the present study suggests that the consumption of AST leaves may beneficial for the treatment of many diseases.

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Section: Antitumor Activitysupporting

confidence: 87%

Section: Antitumor Activitymentioning

confidence: 99%

Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Wang

Umair

et al. 2016

J Food Sci Technol

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“…Complement among other things play a direct part in the defense, such as primary defense against bacterial invasions and viral infections. Complement fixation activity of polysaccharides from plants has previously been used as an indicator for effect on the immune system (Inngjerdingen et al, 2013;Michaelsen et al, 2000).…”

Section: Structure-activity Relationship Of the Polysaccharidesmentioning

confidence: 99%

Polysaccharides with immunomodulating activity from roots of Gentiana crassicaulis

Zou

Chen

et al. 2017

Carbohydrate Polymers

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“…Jinsixiaozao, and fractions containing more uronic acid had stronger free radical scavenging activities than fractions with no uronic acid [ 22 ]. Inngjerdingen et al [ 26 ] also reported that acidic polysaccharide fractions exhibited more effective complement fixation activity than its neutral fractions.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Different Purifying Methods on the Chemical Properties, in Vitro Anti-Tumor and Immunomodulatory Activities of Abrus cantoniensis Polysaccharide Fractions

Brennan

et al. 2016

IJMS

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Abrus cantoniensis (Hance) is a popular Chinese vegetable consumed as a beverage, soup or folk medicine. To fully exploit the potential of the polysaccharide in Abrus cantoniensis, nine polysaccharide fractions of Abrus cantoniensis were isolated and purified (AP-AOH30-1, AP-AOH30-2, AP-AOH80-1, AP-AOH80-2, AP-ACl-1, AP-ACl-2, AP-ACl-3, AP-H and AP-L). Fourier-transform infrared spectroscopy (FT-IR) and gas chromatography (GC) were used to characterize these Abrus polysaccharides fractions (APF). In vitro anti-tumor and immunomodulatory activities were also investigated and compared using the rank-sum ratio (RSR) method. Results demonstrated significant differences in the structure and bioactivities among APF, which were associated to the process used for their purification. Among the APF, AP-ACl-3 yield was 613.5 mg/kg of product and consisted of rhamnose (9.8%), arabinose (8.9%), fructose (3.0%), galactose (9.9%), glucose (4.3%), galacturonic acid (3.0%) and glucuronic acid (61.1%) with a molecular weight of 4.4 × 104 Da. Furthermore, AP-ACl-3 exhibited considerable bioactivities significantly preventing the migration of MCF-7 cells and stimulating lymphocyte proliferation along with nitric oxide (NO) production of peritoneal macrophages. AP-ACl-3 could be explored as a novel potential anti-tumor and immunomodulatory agent.

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A comparison of bioactive aqueous extracts and polysaccharide fractions from roots of wild and cultivated Cochlospermum tinctorium A. Rich

Cited by 24 publications

References 35 publications

Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Ultrasound-assisted extraction of polysaccharides from Artemisia selengensis Turcz and its antioxidant and anticancer activities

Polysaccharides with immunomodulating activity from roots of Gentiana crassicaulis

The Effects of Different Purifying Methods on the Chemical Properties, in Vitro Anti-Tumor and Immunomodulatory Activities of Abrus cantoniensis Polysaccharide Fractions

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