A comparison of cell‐mediated immunity and suppressor T‐cell function in asthmatic and normal children

Harper, Thomas B.; Gaumer, H R; Waring, William W.; Brannon, Richard B.; Salvaggio, John E.

doi:10.1111/j.1365-2222.1980.tb02137.x

Cited by 33 publications

(16 citation statements)

References 25 publications

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“…Oral theophylline has been shown to result in an increase in CD8 + cells in peripheral blood samples (28–30). However, another paediatric study found a reduction in suppressor T‐cells similar to that observed in our group of patients with no difference whether or not the children were treated with theophylline (31). This is in accordance with our results.…”

Section: Immunomodulatory Effectssupporting

confidence: 86%

Low‐dose theophylline in childhood asthma: a placebo‐controlled, double‐blind study

Suessmuth

Freihorst

Gappa

2003

Pediatric Allergy Immunology

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Regular anti-inflammatory treatment is essential in treating persistent asthma. Most commonly, inhaled corticosteroids (ICS) are used. However, especially in children, there is concern about the long-term safety of ICS such that doses should be kept to a minimum. The use of theophylline has decreased because of frequent side-effects in therapeutic doses. In adults, there have been reports about an immunomodulatory effect of low-dose theophylline. To study the clinical and immunomodulatory effect in children, 36 patients (mean age 12.5 SD 2.4 years) with moderate, persistent asthma on regular ICS were recruited into a placebo-controlled, double-blind study. After a 6-week run-in period, patients received either theophylline 10 mg/kg bodyweight or placebo for 12 weeks. Diary cards, lung function, peripheral blood lymphocyte subpopulations and serum eosinophil cationic protein (sECP) were assessed. In the treatment group, mean serum theophylline was 7.1 mg/l. There was no change in symptoms or use of rescue medication. Mean (SD) peak expiratory flow (PEF) increased from 86% (24) to 95% (18) predicted. sECP decreased from 43.2 microg/l (32.5) to 26.5 microg/l (16.9) (p = 0.02). Lymphocyte subpopulations did not change. The study failed to show a beneficial clinical or an immunomodulatory effect of theophylline when used in low doses. These results do not support a more important role of theophylline in the long-term treatment of moderate childhood asthma.

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Section: Immunomodulatory Effectssupporting

confidence: 86%

Low‐dose theophylline in childhood asthma: a placebo‐controlled, double‐blind study

Suessmuth

Freihorst

Gappa

2003

Pediatric Allergy Immunology

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“…The number of T lymphocytes, T suppressor subset and their functional activity in asthmatic patients have been examined but results remain controversial. Some authors have reported normal T-lymphocyte numbers and activity in asthmatic patients (McGeady, Saraclar & Mansmann, 1976;Harper et al, 1980), while others reported depressed T-cell numbers and function (Gupta et al, 1975;Grove et al, 1975). Data concerning the subpopulations of T lymphocytes in children with bronchial asthma and the effect of theophylline treatment on this subpopulation have been published by Gupta, Fikrig and Good (1980) and Harper et al (1980).…”

Section: Introductionmentioning

confidence: 99%

“…Some authors have reported normal T-lymphocyte numbers and activity in asthmatic patients (McGeady, Saraclar & Mansmann, 1976;Harper et al, 1980), while others reported depressed T-cell numbers and function (Gupta et al, 1975;Grove et al, 1975). Data concerning the subpopulations of T lymphocytes in children with bronchial asthma and the effect of theophylline treatment on this subpopulation have been published by Gupta, Fikrig and Good (1980) and Harper et al (1980). In the present study eleven children with extrinsic asthma were studied before and 1 month following theophylline treatment testing both the T-cell activity as well as the T-suppressor-cell subset.…”

Section: Introductionmentioning

confidence: 99%

Induction of suppressor T cells in asthmatic children by theophylline treatment

Shohat

Volovitz

Varsano

1983

Clin Experimental Allergy

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Summary The absolute T‐cell numbers and function, and the T‐suppressor‐cell subset were tested in eleven children with extrinsic asthma prior to and 1 month after theophylline treatment. Low mean T‐suppressor‐cell number and function was found in the asthmatic children, which returned to normal levels and function after 1 month of theophylline treatment. A normal mean T‐cell number was found in this group of children prior to, and 1 month after, theophylline treatment. An obvious correlation between the clinical severity of the asthma and the number of T suppressor cells was found. It is suggested that theophylline most probably activated the T suppressor cells in the asthmatic children.

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“…A relative defi-ciency of suppressor T lymphocytes has been reported in patients with allergic rhinitis (11,12), atopic dermatitis (13), and both allergic (14) and nonallergic asthma (15,16). A decrease in T lymphocyte suppressor cell numbers and in mitogen induced suppressor cell activity has been described in asthma (17)(18)(19)(20)(21)(22). A decrease in peripheral blood suppressor cells has been shown in chronic asthmatics who were refractory to corticosteroid therapy (23).…”

Section: Introductionmentioning

confidence: 99%

Depletion of OX-8 lymphocytes from the blood and airways using monoclonal antibodies enhances the late airway response in rats.

Olivenstein¹,

Renzi²,

Yang³

et al. 1993

J. Clin. Invest.

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Recent evidence supports a role for T lymphocytes in allergic airway responses. We hypothesized that reducing blood T suppressor cells (Ts) might increase the late airway response (LR). Sprague-Dawley (SD) rats were sensitized with ovalbumin (OA). On days 8, 10, and 12, postsensitization test SD (n = 14) received monoclonal antibody intravenously (OX-8; 1 mg) specific to rat Ts. Controls received saline (n = 7) or mouse ascites IgG (n = 7). On day 14, animals were challenged with OA aerosol (5% wt/vol) for 5 min, lung resistance was recorded for 8 h (n = 18) and bronchoalveolar lavage was performed. The LR was determined from the area under the lung resistance vs time curve from 75 to 480 min after challenge. In the remaining 10 rats, airway lymphocyte subsets were measured 8 h after OA aerosol challenge in minced and digested lungs. A decrease in percentage of blood and airway Ts, respectively, in test animals was observed vs controls (blood: 6.27±0.84 vs 32.95±1.94, P < 0.001); (airway: 5.05±0.66 vs 24.5±3.05, P < 0.02). Blood and airway helper T lymphocytes did not differ between test and control animals. The LR was significantly increased in test (22.89±3.92) vs controls (4.22±2.18, P <0.001). Bronchoalveolar lavage macrophages, neutrophils and lymphocytes, and serum OA-specific IgE were also significantly elevated (P < 0.05) in test animals. We conclude that Ts play an important role in attenuating the LR in SD rats. (J.

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A comparison of cell‐mediated immunity and suppressor T‐cell function in asthmatic and normal children

Cited by 33 publications

References 25 publications

Low‐dose theophylline in childhood asthma: a placebo‐controlled, double‐blind study

Low‐dose theophylline in childhood asthma: a placebo‐controlled, double‐blind study

Induction of suppressor T cells in asthmatic children by theophylline treatment

Depletion of OX-8 lymphocytes from the blood and airways using monoclonal antibodies enhances the late airway response in rats.

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