A Comparison of Cephazolin Plus Metronidazole Versus Ticarcillin in The Prevention of Post‐operative Sepsis Following Abdominal Surgery

The pharmacokinetics of the beta 1-selective adrenergic antagonist (R,S)-celiprolol has been studied after oral administration of 200 mg celiprolol-HCl to 8 healthy volunteers and 8 patients with various degrees of impaired renal function. No significant difference was found between the two enantiomers in the control group or in the patients. In healthy volunteers an average of 9.8% of the dose of R-(+)-celiprolol and 9.5% of S-(-)-celiprolol was recovered unchanged in the urine. Renal impairment reduced the urinary excretion of both enantiomers to the same extent according to the severity of the uraemia, producing higher AUCs. Nevertheless, the terminal half-lives of the R- and S-enantiomers were not significantly different between the groups. Dosage reduction in patients with renal impairment does not seem to be necessary.

show abstract

Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function

Hartmann

Frölich

Krauss

et al. 1990

Eur J Clin Pharmacol

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A Comparison of Cephazolin Plus Metronidazole Versus Ticarcillin in The Prevention of Post‐operative Sepsis Following Abdominal Surgery

Cited by 1 publication

References 7 publications

Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function

Comparative enantioselective pharmacokinetic studies of celiprolol in healthy volunteers and patients with impaired renal function

Contact Info

Product

Resources

About