The prediction performance of combustion models in the Fire Dynamics Simulator (FDS) were evaluated by comparing with experiment for compartment propane gas fires. The mixture fraction model in the FDS v5.5.3 and Eddy Dissipation Concept (EDC) model in the FDS v6.6.3 were adopted in the simulations. Four chemical reaction mechanisms, such as 1-step Mixing Controlled, 2-step Mixing Controlled, 3-step Mixing Controlled and 3-step Mixed (Mixing Controlled + finite chemical reactions) reactions, were implemented in the EDC model. The simulation results with each combustion model showed similar level for the temperature inside the compartment. The prediction performance of FDS with each combustion model showed significant differences for the CO concentration while no distinguished differences were identified for the O2 and CO2 concentrations. The EDC 3-step Mixing Controlled largely over-predicted the CO concentration obtained by experiment and the mixture fraction model under-predicted the experiment slightly. The EDC 3-step Mixed showed the best prediction performance for the CO concentration and the EDC 2-step Mixing Controlled also predicted the CO concentration reasonably. The EDC 1-step Mixing Controlled significantly under-predict the experimental CO concentration when the previously suggested CO yield was adopted. The FDS simulation with the EDC 1-step Mixing Controlled showed difficulties in predicting the CO2 concentration when the CO yield was modified to predict the CO concentration reasonably.