A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19

Song, Jia; Hu, Weihang; Yu, Yihua; Shen, Xin; Wang, Yueben; Yan, Jing; Yang, Xianghong; Gong, Sitang; Wang, Minjia

doi:10.12659/msm.925047

Cited by 26 publications

(29 citation statements)

References 25 publications

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“…A hipertensão é uma das comorbidades, que em pacientes com COVID-19, possuem risco aumentado de resultados adversos (SONG J, et al, 2020;GAO C, et al, 2020). Foi postulado que os inibidores da enzima de conversão da angiotensina e os bloqueadores do receptor da angiotensina poderiam aumentar ou diminuir a mortalidade em pacientes com COVID-19 devido a entrada viral do SARS-CoV-2 por meio da enzima conversora de angiotensina 2 (VICENZI M, et al, 2020;GAO C, et al, 202O;ZHANG P et al, 2020).…”

Section: Hipertensão E Uso De Anti-hipertensivounclassified

“…Em dezembro de 2019, foram identificados na região central da China os primeiros casos da pneumonia causada pelo novo coronavírus (SARS-CoV-2). A doença ocasionada pelo vírus de RNA encapsulado, COVID-19, rapidamente se alastrou para os demais continentes, se tornando uma emergência de saúde pública internacional (SONG J, et al, 2020;GAO C, et al, 2020).…”

Section: Introductionunclassified

“…A apresentação clínica da COVID-19 é variável, indo desde indivíduos assintomáticos a indivíduos que desenvolvem formas graves da doença. O curso clínico da infecção é caracterizado por sintomas do trato respiratório, febre, tosse seca e dispneia; mas os pacientes também podem apresentar cefaleia, alterações de olfato e paladar, diarreia, fadiga e complicações associadas à pneumonia (SONG J, et al, 2020;SHI S, et al, 2020).…”

Section: Introductionunclassified

“…Os fatores de risco mais associados a desfechos graves e à mortalidade são idade avançada (≥60), sexo masculino, presença de comorbidades como hipertensão, diabetes mellitus, doença cerebrovascular e doença cardiovascular (SONG J, et al, 2020;GAO C, et al, 2020).…”

Section: Introductionunclassified

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Polímeros Empregados Em Período De Pandemia Sars-Cov-2 a Importância Dos Polímeros Durante a Pandemia De Covid-19

Corrêa¹,

Corrêa²

2021

Pesquisas E Evoluções Voltadas Para as Ciências Da Saúde

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Section: Hipertensão E Uso De Anti-hipertensivounclassified

Section: Introductionunclassified

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Polímeros Empregados Em Período De Pandemia Sars-Cov-2 a Importância Dos Polímeros Durante a Pandemia De Covid-19

Corrêa¹,

Corrêa²

2021

Pesquisas E Evoluções Voltadas Para as Ciências Da Saúde

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“…1,2 Multiple studies have shown that older adults with COVID-19 have high risk of mortality, mainly due to the presence of multiple comorbidities. [3][4][5][6][7] In addition, many studies have shown that older patients are more likely to need intensive care unit (ICU) admission for management of respiratory complications. [8][9][10][11] Among the elderly, heart failure, peripheral artery disease, C-reactive protein level, need for oxygen support, respiratory rate, presence of lung crackles at presentation, shorter interval from onset of symptoms to hospitalization, length of hospital stay, and male sex have been shown to be associated with higher risk of mortality; 12 however, old age remains an independent risk factor for both hospitalization and mortality after controlling for a myriad of factors.…”

Section: Introductionmentioning

confidence: 99%

Predictors of Hospitalization Among Older Adults with COVID-19 in Saudi Arabia: A Cross-Sectional Study of a Nationally Representative Sample

Alamri¹,

Alsofayan²,

AlRuthia³

et al. 2021

RMHP

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Background The aim of this study was to identify the predictors of hospitalization in older (≥60 years) patients with coronavirus disease-19 (COVID-19) in Saudi Arabia. Methods Patients were randomly selected from a COVID-19 database maintained by the Ministry of Health, Saudi Arabia. All patients were aged ≥60 years, had reverse transcriptase-polymerase chain reaction (RT-PCR)-confirmed COVID-19, and were registered in the database during March 2020 to July 2020. Medical and sociodemographic characteristics were retrieved from the database. Additional data were collected by telephone interviews conducted by trained health professionals. Descriptive statistics and multiple logistic regression analyses were used to analyze the relationship between patient characteristics and the risk of hospitalization. Results Of the 613 included patients (51.1% females), more than half (57.3%) were between 60 to 69 years of age, and 53% (324/613) had been hospitalized. The independent predictors of hospitalization included age ≥65 years (OR = 2.35, 95% CI: 1.66–3.33, P < 0.001), having more than one comorbidity (OR = 1.55, 95% CI: 1.09–2.20, P = 0.01), diabetes mellitus (OR = 1.52, 95% CI: 1.09–2.11, P = 0.01), hypertension (OR = 1.40, 95% CI: 1.007–1.97, P = 0.04), chronic kidney disease (OR = 3.87, 95% CI: 1.41–10.58, P = 0.008), and history of hospital admission within the preceding year (OR = 1.69, 95% CI: 1.11–2.55, P = 0.013). Risk of hospitalization was lower in males (OR = 0.65, 95% CI: 0.43–0.90, P = 0.01) and in patients co-living with health care workers (OR = 0.64, 95% CI: 0.43–0.96, P = 0.03). Conclusion Factors associated with higher risk of COVID-19-associated hospitalization should be used in prioritizing older adults’ admission. Future studies with more robust designs should be conducted to examine the risk of COVID-19-associated illness severity and mortality.

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Retracted: COVID‐19 mortality and its predictors in the elderly: A systematic review

Dadras

SeyedAlinaghi

Karimi

et al. 2022

Health Science Reports

126

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Background and Aims: Older people have higher rates of comorbidities and may experience more severe inflammatory responses; therefore, are at higher risk of death. Herein, we aimed to systematically review the mortality in coronavirus disease 2019 (COVID-19) patients and its predictors in this age group.Methods: We searched PubMed, Web of Science, and Science Direct using relevant keywords. Retrieved records underwent a two-step screening process consisting of title/abstract and full-text screenings to identify the eligible studies.Results: Summarizing findings of 35 studies demonstrated that older patients have higher mortality rates compared to the younger population. A review of articles revealed that increasing age, body mass index, a male gender, dementia, impairment or dependency in daily activities, presence of consolidations on chest X-ray, hypoxemic respiratory failure, and lower oxygen saturation at admission were risk factors for death. High D-dimer levels, 25-hydroxy vitamin D serum deficiencies, high C-reactive protein (≥5 mg/L) levels plus any other abnormalities of lymphocyte,

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A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19

Cited by 26 publications

References 25 publications

Polímeros Empregados Em Período De Pandemia Sars-Cov-2 a Importância Dos Polímeros Durante a Pandemia De Covid-19

Polímeros Empregados Em Período De Pandemia Sars-Cov-2 a Importância Dos Polímeros Durante a Pandemia De Covid-19

Predictors of Hospitalization Among Older Adults with COVID-19 in Saudi Arabia: A Cross-Sectional Study of a Nationally Representative Sample

Retracted: COVID‐19 mortality and its predictors in the elderly: A systematic review

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