A Comparison of Clinical Outcomes for Breast-conserving Treatment and Mastectomy for Early Breast Cancer

Abstract

Purpose: To compare the treatment outcomes and to analyze prognostic factors between the use of a breast-conserving treatment (BCT) and a mastectomy for early stage breast cancer. Materials and Methods: We retrospectively reviewed 1,200 patients with pathological stage T1-2N0 breast cancer who received surgery between September 1994 and December 2002 at Samsung Medical Center. We compared the patient characteristics and treatment outcomes between the two treatment groups. Results: Among the 1,174 eligible patients, 601 (51.2%) patients received a BCT and the remaining 573 (48.8%) patients received a mastectomy. The mastectomy group of patients had significantly more cases with a larger tumor size, multicentricity, extensive intraductal component, and estrogen-and progesterone-receptor negativity. The ten-year overall survival rates (OS) of the BCT and mastectomy groups were 91.96% and 91.01%, respectively (p=0.1274). The ten-year disease-free survival rates (DFS) were 80.48% for the BCT group of patients and 84.95% for the mastectomy group of patients, respectively (p=0.8795). Conclusion:Our study shows some differences in patient characteristics between the two treatment groups. However, these differences did not result in significant survival differences.

Breast-conserving treatment versus mastectomy in T1-2N0 breast cancer: which one is better for Indonesian women?

“…This is similar to a study in Korea, where 23 patients (3.8%) in the BCT and 22 patients (2.1%) in the mastectomy group had local recurrence (p = 0.081). 17 In general, radiotherapy is not associated with an increased risk of contra-lateral breast cancer. The risk of contra-lateral breast cancer after radiotherapy is associated with the increase of follow-up.…”

“…In these patients, 59.2 to 69.4% received adjuvant chemotherapy and 50.1 to 53.6% received hormonal therapy. 17 EORTC study showed that the 10 years distant metastasis in patients receiving BCT and mastectomy were 26.8% and 26.7% respectively (p = 0.24). 18 Veronessi reported in patients with T1N0 breast cancer during follow-up of 20 years that the rates of distant metastases in patients with breast conserving therapy and mastectomy were 23.3% and 24.3%.…”

“…16 A study in Korea showed that 10 year overall survival in patients receiving BCT and mastectomy were 91.96% and 91.01% (p = 0.127). 17 Table 4. Multivariate analysis using cox regression model that the 10 year-survival-rate is similar between mastectomy and BCT (66% vs 61%, p = 0.1).…”