A Comparison of Clinical Results Following High Dose‐Rate Intracavitary Afterloading Irradiation with Co⁶⁰ (Cathetron) and Conventional Radium Therapy for St. I‐II Cervical Carcinoma

Abstract

From 1969From to 1976 patients with St. Ia-Ilb cervical carcinoma were treated with the Cathetron (C) and 84 patients with radium (R). Surgery was carried out on 56.4 % of the patients in group C and 60.7 % in group R two weeks after the intracavitary radiotherapy and 51.5 % of the patients in group C and 45.2 % in group R received external irradiation with or without an operation. There was no statistical fifference in the survival between the two treatment groups, the 5-year crude survival rate being 81.6 % for group C and 78.6 YO for group Rand the 3-year crude survival rates 85.1 YO and 83.3 % respectively. Local recurrence of tumour was more frequent in group R (10.7 %) than in group C (3.0 YO) (p=0.03). There were more early complications during or after the Cathetron (10.9 YO) than radium treatment (3.6 %),without any statistical significance, however. No differences were found in operative difficulties or early postoperative morbidity between the two groups during or after radical operations after intracavitary radiotherapy.

A Comparison of Clinical Results Following High Dose‐Rate Intracavitary Afterloading Irradiation with Co60 (Cathetron) and Conventional Radium Therapy for St. I‐II Endometrial Carcinoma

“…Hospitalization, the methods of anaesthesia, cervical dilatation, the single and overall treatment times, the dose calculations with the help of the radiographs taken after the application ofthe catheters and the use ofprophylactic antibiotics followed the same patterns with the cervical carcinoma patients and have been described previously (53). In the early years, 1970 and 1971, the treatment was given in 3 to 5 fractions of 10 Gy each to point A and the total dose to point A ranged from 30 to 50 Gy generally.…”

High-Dose-Rate Brachytherapy as the Primary Treatment of Medically Inoperable Stage I–II Endometrial Carcinoma

“…ventional radium therapy, Taina [5] from Turku, Finland, In a study on the perioperative morbidity and mortality reported 91 stage I-II endometrial cancer patients treated of gynecologic LDR brachytherapy from University of Minby RT, followed by surgery in 80% of patients in the radium nesota, Dusenbery et al [24] reported 6.4% life-threatening (LDR) group and in 59% of patients in the HDR group, and complications and 1.5% mortality rate related to the procefound no statistically significant difference in 5-year survival dure. Chao et al [25] reported 96 patients with medically rates between the two treatment groups (82.4% versus inoperable stage I endometrial carcinoma treated by LDRB with a morbidity rate of 4.2% and mortality rate of 2.1%.…”

Complications Following High and Low Dose‐Rate Intracavitary Radiotherapy for St. I‐II Cervical Carcinoma: A Comparison of Remotely Afterloaded CO60 (Cathetron) and Conventional Radium Therapy

“…As a conclusion it can be stated that with the fractionation and total dose of C treatment used in 1972-1976 the rate of complications does not differ from that of conventional radium therapy. We have also previously shown that the survival rates were high and equal for both treatment groups (47) and therefore there is no problem in disposing ofradium in the treatment of St.…”

“…The subjects and treatment methods have been previously described in detail (47). Follow-up and statistical methods.…”

“…Complete follow-up was achieved. The survival rates were identical for both treatment groups (47). During the first year after treatment the patients were examined at 1 to 4 months, during the second year at 4 to 6 months and later at 6 to 12 months intervals.…”