A comparison of depth of tissue injury caused by different modes of electrosurgical current in a pig colon model

Chino, Akiko; Karasawa, Takafumi; Uragami, Naoyuki; Endo, Yutaka; Takahashi, Hiroshi; Fujita, Rikiya

doi:10.1016/s0016-5107(03)02712-3

Cited by 53 publications

(36 citation statements)

References 14 publications

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“…Electrosurgical instruments generally have two different monopolar application modes, viz., cutting mode and coagulation mode [25,38,39]. Most instruments utilize a constant amplitude sinus rf AC for cutting and attenuated waveform packets for coagulation as it is demonstrated in Figure S4.…”

Section: Resultsmentioning

confidence: 99%

Electrospray Post-Ionization Mass Spectrometry of Electrosurgical Aerosols

Guenther

Schäfer

Balog³

et al. 2011

J. Am. Soc. Mass Spectrom.

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The feasibility of electrospray (ES) ionization of aerosols generated by electrosurgical disintegration methods was investigated. Although electrosurgery itself was demonstrated to produce gaseous ions, post-ionization methods were implemented to enhance the ion yield, especially in those cases when the ion current produced by the applied electrosurgical method is not sufficient for MS analysis. Post-ionization was implemented by mounting an ES emitter onto a Venturi pump, which is used for ion transfer. The effect of various parameters including geometry, high voltage setting, flow parameters, and solvent composition was investigated in detail. Experimental setups were optimized accordingly. ES post-ionization was found to yield spectra similar to those obtained by the REIMS technique, featuring predominantly lipid-type species. Signal enhancement was 20-to 50-fold compared with electrosurgical disintegration in positive mode, while no improvement was observed in negative mode. ES post-ionization was also demonstrated to allow the detection of non-lipid type species in the electrosurgical aerosol, including drug molecules. Since the tissue specificity of the MS data was preserved in the ES post-ionization setup, feasibility of tissue identification was demonstrated using different electrosurgical methods.

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Section: Resultsmentioning

confidence: 99%

Electrospray Post-Ionization Mass Spectrometry of Electrosurgical Aerosols

Guenther

Schäfer

Balog³

et al. 2011

J. Am. Soc. Mass Spectrom.

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“…Lesions greater than 10 mm (so-called "laterally spreading tumours") or flat depressed lesions can be safely and effectively resected by EMR, once endoscopic resectability is confirmed by one of the above methods. For EMR, the injection solution lifts the lesion above the surrounding mucosa, permitting safer snaring using a blended [45] or cutting current [46]. Depending on size and site, lesions may be removed en bloc or piecemeal, but where a lesion is removed piecemeal, additional treatment with argon plasma coagulation lowers the rate of recurrence [47].…”

Section: Endoscopic Managementmentioning

confidence: 99%

Flat colorectal neoplasms: endoscopic detection, clinical relevance and management

Suzuki

Saunders

2004

Tech Coloproctol

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The prevalence of flat neoplasms in Western countries appears to be similar to Japan. These lesions are difficult to detect but careful examination of the colonic mucosa with the aid of targeted dye spray reveals subtle mucosal changes characteristic of these lesions. Management of flat neoplasms depends on their size, site and on whether the lesions lift after submucosal injection. In this article, we highlight the typical features of flat neoplasms and discuss their optimal management in routine practice.

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“…As reported 21 , overnight fasting can provide adequate bowel preparation in murine preclinical models. Occasionally, residual gut contents obscured the view using water-assisted colonoscopy.…”

Section: Resultsmentioning

confidence: 89%

Development of a murine colonoscopic polypectomy model (with videos)

Ertem

Dashwood

Rajendran

et al. 2016

Gastrointestinal Endoscopy

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Background Colonoscopy provides a means for screening and removal of colonic adenomas, preventing such lesions from progressing to late-stage carcinoma. No preclinical model currently exists that closely parallels the clinical scenario with respect to polyp resection and recovery post-endoscopy. Methods When we used the polyposis in rat colon (Pirc) model, a new polypectomy methodology was developed. A novel “PLC” classification system (Polyp Number/Location/Clockwise orientation) also was devised in order to accurately and reproducibly specify the location of each lesion within the colon. Results One week after surgery, injuries to the polypectomy site were confined to the submucosa, indicating that little or no damage occurred to the inner muscle layer of the colon. Polypectomy sites occasionally continued to show ulcer formation, whereas others exhibited tissue regeneration. A pilot study (n = 6 animals), involving a total of 37 polypectomies, confirmed that the new methodology could be applied using either air insufflation or water-assisted techniques, with either hot or cold snare. As a general observation, polyps tended to be more fully distended and less flattened against the colonic mucosa using the water-assisted protocol, increasing the technical ease of ensnaring and resecting lesions. The PLC system proved to be straightforward, and facilitated longitudinal studies by allowing the investigator to track each polypectomy site upon repeated examination. Conclusions The Pirc model was ideally suited to colonoscopy with polypectomy. Because the main cause of morbidity in the Pirc model is blockage of the colon, polypectomy can be used as a preventive strategy, and will likely facilitate long-term investigations of single agent and combination therapies with potential direct clinical relevance.

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A comparison of depth of tissue injury caused by different modes of electrosurgical current in a pig colon model

Cited by 53 publications

References 14 publications

Electrospray Post-Ionization Mass Spectrometry of Electrosurgical Aerosols

Electrospray Post-Ionization Mass Spectrometry of Electrosurgical Aerosols

Flat colorectal neoplasms: endoscopic detection, clinical relevance and management

Development of a murine colonoscopic polypectomy model (with videos)

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