A Comparison of Developmental Outcomes of Adolescent Neonatal Intensive Care Unit Survivors Born with a Congenital Heart Defect or Born Preterm

Easson, Kaitlyn; Dahan‐Oliel, Noémi; Rohlicek, Charles V.; Sahakian, Sossy K.; Brossard‐Racine, Marie; Mazer, Barbara; Riley, Patricia; Maltais, Désirée B.; Nadeau, Lucie; Hatzigeorgiou, Sean; Schmitz, N.; Majnemer, Annette

doi:10.1016/j.jpeds.2018.11.002

Cited by 29 publications

(23 citation statements)

References 51 publications

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“…Interestingly, the affected tracts are very similar to those altered in preterm born adolescents (Li et al., 2015; Vollmer et al., 2017). It has been suggested that the cognitive deficits of preterm born children are akin to those in CHD children (Easson et al., 2018). The findings from our current study provide additional evidence for structural similarities between these populations, manifested as changes in FA in the cerebral peduncle, cingulum, posterior corona radiata, corpus callosum, external and internal capsule, forceps minor, fornix, fronto-occipital fasciculus, longitudinal fasciculus, and uncinate fasciculus.…”

Section: Discussionmentioning

confidence: 99%

“…In healthy children and adolescents, the maturation of fronto-parietal (Krogsrud et al., 2018; Østby et al., 2011; Peters et al., 2012; Vestergaard et al., 2010), fronto-temporal (Krogsrud et al., 2018), and frontal interhemispheric (Krogsrud et al., 2018) white matter structures is associated with improving working memory performance. In preterm-born adolescents, a population with a similar profile of cognitive deficits as in CHD patients (Easson et al., 2018), reduced anisotropy of white matter microstructure was observed compared to term-born children and was associated with working memory impairments (Vollmer et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

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Altered frontal white matter microstructure is associated with working memory impairments in adolescents with congenital heart disease: A diffusion tensor imaging study

Ehrler

Latal

Kretschmar

et al. 2020

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered frontal white matter microstructure is associated with working memory impairments in adolescents with congenital heart disease: A diffusion tensor imaging study

Ehrler

Latal

Kretschmar

et al. 2020

NeuroImage: Clinical

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“…Nevertheless, we found similarities between our findings and the morphometric analyses performed in very preterm children and adolescents. It has been suggested before that the brain's maldevelopment and injury pattern, as well as, the neurodevelopmental outcomes profile in preterm children are comparable to children with CHD (Back & Miller, 2014;Easson et al, 2019;McQuillen & Miller, 2010;Miller & Ferriero, 2009;. In very preterm children, the hippocampus has been described to be less inverted when compared to term children imaged at a similar corrected age (Thompson et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Shape analyses have the potential to explain structural differences such as bending, flattening or local differences which may provide biologically meaningful information about the development of the hippocampus (M. M. Chakravarty et al, 2015). It has been suggested before that the brain's maldevelopment and injury pattern, as well as, the neurodevelopmental outcomes profile in preterm children are comparable to children with CHD (Back & Miller, 2014;Easson et al, 2019;McQuillen & Miller, 2010;Miller & Ferriero, 2009;. Nevertheless, we found similarities between our findings and the morphometric analyses performed in very preterm children and adolescents.…”

Section: T a B L E 4 Brief-a Mean Score Differences Between Chd And Cmentioning

confidence: 99%

Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease

Fontes

Rohlicek

Saint‐Martin

et al. 2019

Human Brain Mapping

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There is a high prevalence of neurodevelopmental impairments in individuals living with congenital heart disease (CHD) and the neural correlates of these impairments are not yet fully understood. Recent studies have shown that hippocampal volume and shape differences may provide unique biomarkers for neurodevelopmental disorders. The hippocampus is vulnerable to early life injury, especially in populations at risk for hypoxemia or hemodynamic instability such as in neonates with CHD. We compared hippocampal gray and white matter volume and morphometry between youth born with CHD (n = 50) aged 16–24 years and healthy peers (n = 48). We also explored whether hippocampal gray and white matter volume and morphometry are associated with executive function and self‐regulation deficits. To do so, participants underwent 3T brain magnetic resonance imaging and completed the self‐reported Behavior Rating Inventory of Executive Function—Adult version. We found that youth with CHD had smaller hippocampal volumes (all statistics corrected for false discovery rate; q < 0.05) as compared to controls. We also observed significant smaller surface area bilaterally and inward displacement on the left hippocampus predominantly on the ventral side (q < 0.10) in the CHD group that were not present in the controls. Left CA1 and CA2/3 were negatively associated with working memory (p < .05). Here, we report, for the first‐time, hippocampal morphometric alterations in youth born with CHD when compared to healthy peers, as well as, structure–function relationships between hippocampal volumes and executive function. These differences may reflect long lasting alterations in brain development specific to individual with CHD.

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“…Higher scores of the SDQ, Conners-3, or SRS indicate more behavioral problems. All three questionnaires are frequently used in both clinical practice and research [SDQ: e.g., (26,27), SRS: e.g., (28,29), Connors-3: e.g., (28,30)].…”

Section: Developmental and Behavioral Assessmentmentioning

confidence: 99%

Social and Behavioral Difficulties in 10-Year-Old Children With Congenital Heart Disease: Prevalence and Risk Factors

et al. 2020

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Children with congenital heart disease (CHD) may be at increased risk for neurodevelopmental impairments. Long-term behavioral profiles and respective risk factors are less frequently described. The aim of this study was to evaluate multidimensional behavioral outcomes and associated medical, psychological, and social risk factors in children with complex CHD. At 10-years of age, 125 children with CHD were assessed for general behavioral difficulties, attention deficit hyperactivity disorder (ADHD)-related behavior, and social interaction problems and were compared to normative data. Medical and cardiac factors, IQ, maternal mental health at 4 years of age and parental socioeconomic status were tested as predictors for all behavioral outcomes. Children with CHD showed no significant differences in general behavioral difficulties. However, increased ADHD-related symptoms (p < 0.05) and difficulties in social interaction (p < 0.05) were observed. In 23% of the children, a combination of ADHD-related symptoms and social interaction problems was reported by parents. In multivariate analyses, IQ (p < 0.01) and maternal mental health (p < 0.03) at 4 years of age were found to be predictive for all behavioral outcomes at 10 years while medical and cardiac risk factors were not. Our findings reveal significant difficulties in ADHD-related symptoms and social interaction problems with a significant comorbidity. Behavioral difficulties were not detected with a screening tool but with disorder-specific questionnaires. Furthermore, we demonstrate the importance of maternal mental health during early childhood on later behavioral outcomes of children with CHD. This underlines the importance of identifying and supporting parents with mental health issues at an early stage in order to support the family and improve the child's neurodevelopment.

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A Comparison of Developmental Outcomes of Adolescent Neonatal Intensive Care Unit Survivors Born with a Congenital Heart Defect or Born Preterm

Cited by 29 publications

References 51 publications

Altered frontal white matter microstructure is associated with working memory impairments in adolescents with congenital heart disease: A diffusion tensor imaging study

Altered frontal white matter microstructure is associated with working memory impairments in adolescents with congenital heart disease: A diffusion tensor imaging study

Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease

Social and Behavioral Difficulties in 10-Year-Old Children With Congenital Heart Disease: Prevalence and Risk Factors

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