A Comparison of Different Dosages of a Continuous Preperitoneal Infusion and Systemic Administration of Ropivacaine After Laparotomy in Rats

Kfoury, Toni; Mazoit, Jean‐Xavier; Schumacher, Michaël; Benhamou, Dan; Beloeil, Hélène

doi:10.1213/ane.0b013e31821f108a

Cited by 18 publications

(15 citation statements)

References 26 publications

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“…Therefore, local preperitoneal or intraperitoneal chemical afferentectomy may serve to block vagal afferents thus reducing sensitization. [ 30 31 ] Consequently, that may contribute to enhanced patients recovery,[ 31 ] where the somatic and peritoneal abdominal wounds predispose to autonomic disturbance, catabolic response, fatigue, anorexia, and disturbed sleep rhythm postoperatively. [ 24 ]…”

Section: Discussionmentioning

confidence: 99%

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Preperitoneal postcesarean section bupivacaine analgesia: Comparison between dexamethasone and dexmedetomidine as adjuvants

2018

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Background:The peritoneal wound is frequently neglected during laparotomy. The preperitoneal local anesthetics and many adjuvants were effective for postcesarean analgesia. Analgesia may involve somatic and autonomic components. The preperitoneal bupivacaine and the promising adjuvants dexamethasone or dexmedetomidine were compared in this study.Patients and Methods:Sixty patients subjected to a cesarean section (CS) under general anesthesia divided into two groups using a bolus of preperitoneal bupivacaine 0.7 mg/kg with either 1ug/kg dexmedetomidine (Group P) or 8 mg dexamethasone (Group D). The time to the first analgesic request was the primary outcome.Results:There was a significantly prolonged time to the first analgesic request in the Group P than the Group D and less required preperitoneal injections in the Group P, also pain assessed by Numerical Rating Scale (NRS) was lower in the Group P than the Group D after 6 h postoperatively up to 24 h.Conclusions:Dexmedetomidine provided better analgesia than dexamethasone as an adjuvant to preperitoneal bupivacaine post-CS.

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Section: Discussionmentioning

confidence: 99%

“…In addition to block of nociception, LAs possess also a systemic anti-inflammatory effect,[ 30 ] and block the visceral sensitization at medullar neurons. [ 32 ] Glucocorticoids[ 33 ] as well as dexmedetomidine[ 34 ] provide also an anti-inflammatory effect.…”

Section: Discussionmentioning

confidence: 99%

Preperitoneal postcesarean section bupivacaine analgesia: Comparison between dexamethasone and dexmedetomidine as adjuvants

2018

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“…Recently published data concluded that ropivacaine may be useful in suppressing inflammation, mechanical, and visceral hypersensitivity (28,29) and can even be used to treat chronic pain states in the same way (30). Good postsurgery analgesia management is beneficial for the outcome of surgery.…”

Section: Discussionmentioning

confidence: 99%

Intraperitoneal ropivacaine and early postoperative pain and postsurgical outcomes after laparoscopic herniorrhaphy in toddlers: a randomized clinical trial

Tian

Yang

et al. 2016

Pediatric Anesthesia

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“…High-dose ropivacaine administered via a preperitoneal infusion or systemic boluses had the same effect on mechanical and visceral sensitivity after laparotomy. [23] According to Beaussier M et al, [22] preperitoneal continuous infiltration of 0.2% ropivacaine at 10 ml/h during 48 h was an effective method to relieve pain after open colorectal surgery. It reduced morphine consumption and accelerated the postoperative recovery.…”

Section: Discussionmentioning

confidence: 99%

Preperitoneal Blockade in the Treatment of Patients with Perforated Gastroduodenal Ulcers and Peritonitis

Чарышкин¹,

Yakovlev²,

Демин³

2016

Int J Biomed

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The objective of this study was to improve the results of surgical treatment for patients with perforated gastroduodenal ulcers and peritonitis (PGDU-P) by applying the preperitoneal blockade. Materials and Methods:The study included 102 patients with perforated gastroduodenal ulcers (PGDU) complicated by peritonitis. Patients between 18 and 30 years were predominant. Pain was measured using the Visual Analog Scale (VAS) for Pain. The measurements of intra-abdominal pressure (IAP) by indirect infravesical tensometry were performed daily from the first day after the operation. Surgical interventions (laparotomy, laparoscopic suturing of PGDU, sanitation and drainage of the abdominal cavity) was performed under endotracheal anesthesia in all patients.Patients were divided into two groups depending on the method of postoperative analgesia. Patients of Group 1 (n=62) were subjected only to systemic opioid analgesia (an intramuscular injection of 1% solution of Promedol 1ml 4 times a day). Patients of Group 2 were subjected to systemic opioid analgesia and catheterization of the preperitoneal space for infusion of 0.5% solution of Novocaine in the postoperative period.Results: Postoperative analgesia using preperitoneal blockade after laparotomy and suturing of perforated gastroduodenal ulcers reduced the pain intensity by 2 times in comparison with conventional analgesia. The preperitoneal blockade after laparotomy in PGDU-P patients promotes the effective reduction of intra-abdominal hypertension (IAH) for 2 days. The comparative evaluation of the incidence of the early postoperative complications showed that using preperitoneal blockade contributed to significantly reducing the complications in Group 2. Postoperative mortality was 1.6% in Group 1 and 0 in Group 2. The average length of stay was reduced by approximately 3 days in Group 2 compared to traditional anesthesia. (Int J Biomed. 2016;6(2):114-118.).

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A Comparison of Different Dosages of a Continuous Preperitoneal Infusion and Systemic Administration of Ropivacaine After Laparotomy in Rats

Cited by 18 publications

References 26 publications

Preperitoneal postcesarean section bupivacaine analgesia: Comparison between dexamethasone and dexmedetomidine as adjuvants

Preperitoneal postcesarean section bupivacaine analgesia: Comparison between dexamethasone and dexmedetomidine as adjuvants

Intraperitoneal ropivacaine and early postoperative pain and postsurgical outcomes after laparoscopic herniorrhaphy in toddlers: a randomized clinical trial

Preperitoneal Blockade in the Treatment of Patients with Perforated Gastroduodenal Ulcers and Peritonitis

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