PurposeThe paper aims to examine fall armyworm's (FAW) effect on Ghana's farming households' income and food security status.Design/methodology/approachA sample of 225 farmers, including FAW-infested households and non-FAW-infested households, were interviewed. Gross margin (GM) analysis was used to estimate farmers' farm revenues, and the Household Food Insecurity Access Scores (HFIAS) was employed to measure the food security status of the households. The seemingly unrelated regression (SUR) was adopted to investigate the effect of FAW infestation on gross income and food security.FindingsFrom the study, FAW attack is predominant during the vegetative stage of the maize plant. The empirical results revealed that FAW-infested farms incur loss, whereas non-FAW-infested farmers gained profit. Also, FAW-infested households were mildly food insecure, while non-FAW-infested households were food secured. The results of SUR analysis reveal that FAW infestation decreased farmers' income from maize production and rendered them food insecure.Research limitations/implicationsOne limitation of this study is that it largely depended on a survey; however, future studies can combine both survey and experimental data from the farmers' fields during minor and major growing seasons of maize.Originality/valueGiven the negative consequences of FAW, studies have been conducted across Africa and globally. However, most of these studies concentrated on using geographic information system (GIS) and descriptive statistics without necessarily quantifying the effect of FAW on food security and the profit margins of farming households. Therefore, this study adds to the little literature on the effect of FAW on food security and GM from maize production, which has received less attention in Ghana to the authors' best knowledge.