A comparison of dose distributions in gross tumor volume between boron neutron capture therapy alone and combined boron neutron capture therapy plus intensity modulation radiation therapy for head and neck cancer

Lee, Jia-Cheng; Liu, Yen-Wan Hsueh; Lin, Ting-Yun; Teng, Yi-Chiao; Wang, Ling-Wei

doi:10.1371/journal.pone.0210626

Cited by 14 publications

(11 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using nine patients with recurrent head and neck cancer from THOR, Lee et al analyzed the dose distributions between BNCT alone and BNCT with IMRT. BNCT with IMRT had GTV conformity and improved homogeneity compared to BNCT monotherapy (60).…”

Section: Recurrent Head and Neck Cancersmentioning

confidence: 97%

Boron Neutron Capture Therapy: A Review of Clinical Applications

et al. 2021

View full text Add to dashboard Cite

Boron neutron capture therapy (BNCT) is an emerging treatment modality aimed at improving the therapeutic ratio for traditionally difficult to treat tumors. BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which, after undergoing irradiation with neutrons, yields litihium-7 and an alpha particle. The alpha particle has a short range, therefore preferentially affecting tumor tissues while sparing more distal normal tissues. To date, BNCT has been studied clinically in a variety of disease sites, including glioblastoma multiforme, meningioma, head and neck cancers, lung cancers, breast cancers, hepatocellular carcinoma, sarcomas, cutaneous malignancies, extramammary Paget’s disease, recurrent cancers, pediatric cancers, and metastatic disease. We aim to provide an up-to-date and comprehensive review of the studies of each of these disease sites, as well as a review on the challenges facing adoption of BNCT.

show abstract

Section: Recurrent Head and Neck Cancersmentioning

confidence: 97%

Boron Neutron Capture Therapy: A Review of Clinical Applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Recently, Jai-Cheng reported the comparison of dose distributions in gross tumor volume between BNCT alone and BNCT combined with intensity modulation radiation therapy (IMRT) for head and neck cancer. He suggested that compared to single-fraction BNCT, the multi-fraction IMRT combined with single-fraction BNCT improves the treatment conformity and homogeneity and possibly local tumor control, especially for tumor whose volume is greater than 100 cm [127]. A recent study, published in Radiotherapy and Oncology, demonstrated the efficiency of BNCT in the treatment of locally recurrent head and neck squamous cell carcinoma (HNSCC) patients and also the factors that are favorable for the treatment response and survival [128].…”

Section: Recurrent Head and Neck Regional Tumor Treatment With Bnctmentioning

confidence: 99%

Boron Chemistry for Medical Applications

2020

View full text Add to dashboard Cite

Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a new class for medicinal chemists to use in their drug designs. Carboranes are a class of organometallic compounds containing carbon (C), boron (B), and hydrogen (H) and are the most widely studied boron compounds in medicinal chemistry. Additionally, other boron-based compounds are of great interest, such as dodecaborate anions, metallacarboranes and metallaboranes. The boron neutron capture therapy (BNCT) has been utilized for cancer treatment from last decade, where chemotherapy and radiation have their own shortcomings. However, the improvement in the already existing (BPA and/or BSH) localized delivery agents or new tumor-targeted compounds are required before realizing the full clinical potential of BNCT. The work outlined in this short review addresses the advancements in boron containing compounds. Here, we have focused on the possible clinical implications of the new and improved boron-based biologically active compounds for BNCT that are reported to have in vivo and/or in vitro efficacy.

show abstract

“…A second clinical trial, also phase I/II, was started in 2014 combining BNCT with IGRT and IMRT to try to reduce re-recurrences [ 130 ]. As of 2019, Lee et al, provided evidence suggesting that the single-session dose distribution in terms of homogeneity and conformity might improve when combined with multifraction IMRT [ 131 ]. Additionally, in Taiwan, BNCT was evaluated as a salvage therapy for malignant brain tumors, with preliminary results published in 2020 showing significant effects on maintaining a good quality of life and possibly prolonging a patient’s survival [ 132 ].…”

Section: Clinical Possibilities Of Bnct and Future Perspectivesmentioning

confidence: 99%

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Skwierawska

López-Valverde

Balcerzyk

et al. 2022

Cancers

View full text Add to dashboard Cite

Boron Neutron Capture Therapy (BNCT) is a promising binary disease-targeted therapy, as neutrons preferentially kill cells labeled with boron (10B), which makes it a precision medicine treatment modality that provides a therapeutic effect exclusively on patient-specific tumor spread. Contrary to what is usual in radiotherapy, BNCT proposes cell-tailored treatment planning rather than to the tumor mass. The success of BNCT depends mainly on the sufficient spatial biodistribution of 10B located around or within neoplastic cells to produce a high-dose gradient between the tumor and healthy tissue. However, it is not yet possible to precisely determine the concentration of 10B in a specific tissue in real-time using non-invasive methods. Critical issues remain to be resolved if BNCT is to become a valuable, minimally invasive, and efficient treatment. In addition, functional imaging technologies, such as PET, can be applied to determine biological information that can be used for the combined-modality radiotherapy protocol for each specific patient. Regardless, not only imaging methods but also proteomics and gene expression methods will facilitate BNCT becoming a modality of personalized medicine. This work provides an overview of the fundamental principles, recent advances, and future directions of BNCT as cell-targeted cancer therapy for personalized radiation treatment.

show abstract

A comparison of dose distributions in gross tumor volume between boron neutron capture therapy alone and combined boron neutron capture therapy plus intensity modulation radiation therapy for head and neck cancer

Cited by 14 publications

References 20 publications

Boron Neutron Capture Therapy: A Review of Clinical Applications

Boron Neutron Capture Therapy: A Review of Clinical Applications

Boron Chemistry for Medical Applications

Clinical Viability of Boron Neutron Capture Therapy for Personalized Radiation Treatment

Contact Info

Product

Resources

About