A Comparison of Doxorubicin and COP for Maintenance of Remission in Cats With Lymphoma

Moore, Antony S.; Cotter, Susan M.; Frimberger, Angela E.; Wood, Carrie A.; Rand, William; L'Heureux, Deborah A.

doi:10.1111/j.1939-1676.1996.tb02083.x

Cited by 81 publications

(110 citation statements)

References 2 publications

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“…1.22. 24 The remission length advantage resulting from the addition of doxorubicin to treatment protocols reported by Moore et a124 was also observed in this study, following univariate analysis. Anatomic site was prognostic for both remission duration and survival following univariate analysis.…”

Section: Discussionsupporting

confidence: 62%

Feline Lymphoma (145 Cases): Proliferation Indices, Cluster of Differentiation 3 Immunoreactivity, and Their Association with Prognosis in 90 Cats

Vail

Moore

Ogilvie

et al. 1998

Veterinary Internal Medicne

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211

265

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Paraffin-embedded, formalin-fixed tissue samples from 145 cats with lymphoma were analyzed for cluster of differentiation 3 (CD3, a surface antigen) immunoreactivity, argyrophilic nucleolar organizer region (AgNOR) frequency, and proliferating cell nuclear antigen labeling index (PCNA-LI). This information along with signalment, anatomic site, and feline leukemia virus (FeLV) antigen status was used to determine the potential of these indicators to predict response to therapy, remission, and survival times, and to characterize cats with lymphoma in the era of general availability of FeLV testing and vaccination. Alimentary lymphoma, primarily occurring in older, FeLV-negative cats, was the most common site of involvement. Although the majority of tumors from FeLVpositive cats were CD3-immunoreactive, only one half of CD3-immunoreactive tumors occurred in FeLV-positive cats. Median remission duration and survival times were 126 days and 143 days, respectively, for all cats. Measures of tumor cell proliferation (AgNOR frequency and PCNA-LI) and CD3-immunoreactivity were not predictive of outcome. When all prognostic factors were accounted for by multivariate analysis, response to therapy, FeLV status, and clinical substage were predictive of outcome. FeLVnegative cats that achieved a complete response following induction therapy were likely to have durable (ie, >6-month) responses, particularly when doxoruhicin was included in the chemotherapy protocol. However, FeLV-positive cats had significantly shorter remission and survival times with available chemotherapeutic protocols.Key words: AgNOR; Cancer; Feline leukemia virus; PCNA ymphoma (malignant lymphoma, lymphosarcoma) is L the most common malignancy in domestic cats and accounts for approximately one third of all tumors in this species.' Many cats with lymphoma will achieve remission and return to a good quality of life with appropriate therapy; however, predicting which cats will respond to therapy and which will not is a difficult challenge. termined that markers of proliferation (AgNOR frequency and PCNA-LI) and the cluster of differentiation 3 (CD3, a surface antigen) T-cell phenotype are predictors of treatment response in dogs with lymph~rna.~ The purpose of this study was to determine, in a retrospective fashion, AgNOR frequency, CD3 immunophenotype, and PCNA-LI in a large group of cats with lymphoma and determine if their predictive ability holds true in this species. Such assays could provide rapid, clinically relevant information to better educate clients as to the expected response to therapy as well as a means of prospectively tailoring individual treatments in future trials. In addition, many veterinary oncologists have noted an anecdotal change in the relative frequency of anatomic sites for lymphoma in the last 10-15 years, corresponding to the general availability of feline leukemia virus (FeLV) testing and vaccination programs. This study, therefore, also presents signalment and retroviral and anatomic site data on a large population of cats w...

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Section: Discussionsupporting

confidence: 62%

Feline Lymphoma (145 Cases): Proliferation Indices, Cluster of Differentiation 3 Immunoreactivity, and Their Association with Prognosis in 90 Cats

Vail

Moore

Ogilvie

et al. 1998

Veterinary Internal Medicne

Self Cite

211

265

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“…By contrast, none of the 3 animals in the present study with intraocular lymphoma for which bone marrow aspirate samples were Additionally, other than mild normocytic, normochromic anemia in 1 dog (Hct, 37.6%; reference range, 40% to 55%), no evidence of anemia or thrombocytopenia was detected for any animals in the present study. Determination of primary anatomic location, 19,20 stage, [21][22][23][24][25] and substage 23,24,26 may be important for determination of a prognosis for dogs and cats with lymphoid neoplasia, but this has not been consistently proven, as results of other studies [40][41][42][43][44] indicate that these factors are not significantly correlated with prognosis. Established guidelines for staging of lymphoid neoplasia in domestic animals 27 suggest that involvement of a single lymph node or lymphoid tissue in a single organ represents stage 1 disease, whereas involvement of blood, bone marrow, or organs other than the liver and spleen represents stage 5 disease.…”

Section: Discussionmentioning

confidence: 48%

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

Wiggans¹,

Skorupski²,

Reilly³

et al. 2014

javma

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Objective—To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL). Design—Retrospective case series. Animals—7 dogs and 2 cats with PSOL. Procedures—Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined. Results—Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non–B-cell, non–T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively. Conclusions and Clinical Relevance—Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.

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“…If lymphomas in FeLV-infected cats have higher mitotic rates than those in FeLV-negative cats, this might explain the poorer response to therapy and shorter remission times currently observed in cats with lymphoma but negative for FeLV. 19 These findings fit the general spectrum of lymphoproliferative diseases in humans, where poorly differentiated tumors tend to occur Table 1 for key to diagnostic acronyms.…”

Section: Discussionmentioning

confidence: 78%

The Histologic Classification of 602 Cases of Feline Lymphoproliferative Disease using the National Cancer Institute Working Formulation

Valli

Jacobs

Norris³

et al. 2000

J VET Diagn Invest

126

154

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Abstract. Case information and histologic slides for 688 admissions of feline tissues from 12 veterinary institutions were assembled and reviewed to determine tissues obtained by biopsy or necropsy, age and sex of cat, tumor topography, feline leukemia viral antigen status, histologic frequency of mitoses, diagnosis, presence of necrosis, and presence and degree of sclerosis. Histologic sections were examined to place the lesions in one of the diagnostic categories of the National Cancer Institute working formulation (NCI WF) for lymphomas or lymphoid leukemia. Correlations between the various factors determined were tested using contingency tables and chi-square analysis to provide a statistical comparison between the levels of observations determined by case examination with the numbers expected from chance alone. Significant correlations (P Յ 0.05) were found between diagnosis and tumor topography, the frequency of mitoses, necrosis, sclerosis, and age, between mitoses and necrosis, topography, age, and feline leukemia viral infection status, between topography and necrosis and age, and between leukemia viral status and age. Significant correlations between diagnosis and tumor topography included a greater than expected number of cases of acute and chronic lymphoid leukemia and multicentric distribution of tumor. Small cell lymphomas were more frequent than expected in enteric and cutaneous areas and less frequent than expected in mediastinal, renal, and multicentric areas. In contrast, the high-grade small noncleaved type of lymphomas was found significantly more frequently than expected in the mediastinum and less frequently than expected in enteric tissues. In comparing diagnosis and frequency of mitoses, the lymphomas classified as low grade by the NCI WF were significantly more frequent than expected in the lower categories (0-2/100ϫ) of mitoses, and those classified as high-grade lymphomas were more frequent than expected in the higher categories (4-8/100ϫ) of mitoses. In comparing diagnosis and sclerosis, diffuse sclerosis was more frequent than expected for the intermediate grade lymphomas of mixed cell type and for the highgrade lymphomas of the immunoblastic polymorphous type. In comparing diagnosis and locally extensive necrosis, this feature was more frequently observed than expected for cases of intermediate grade lymphoma of the small-cleaved cell category and for the high-grade lymphoma of the immunoblastic cell type. In comparing mitoses and necrosis, the lower grade lymphomas were, in general, characterized by a lower frequency of mitoses and a lower incidence of necrosis then would be expected from chance alone. In contrast, the higher grade lymphomas were characterized by more frequent mitoses and a higher incidence of necrosis. In tests comparing mitoses and tumor topography, lymphomas of the alimentary tract were more frequently observed than expected in the category with the lowest level of mitoses (0-1/100ϫ), whereas lymphomas of the mediastinum and kidney were more frequently observed ...

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A Comparison of Doxorubicin and COP for Maintenance of Remission in Cats With Lymphoma

Cited by 81 publications

References 2 publications

Feline Lymphoma (145 Cases): Proliferation Indices, Cluster of Differentiation 3 Immunoreactivity, and Their Association with Prognosis in 90 Cats

Feline Lymphoma (145 Cases): Proliferation Indices, Cluster of Differentiation 3 Immunoreactivity, and Their Association with Prognosis in 90 Cats

Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985–2013)

The Histologic Classification of 602 Cases of Feline Lymphoproliferative Disease using the National Cancer Institute Working Formulation

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