“…24,25 In the absence of data from suitably powered randomized trials, a recent systematic review comparing 'early' to 'late' initiation of RRT for AKI concluded that there was insufficient evidence to guide practice. 26 Uncertainty about the optimal timing of RRT initiation for critically ill patients with AKI likely contributes to practice variation, which may affect patient outcomes. Accordingly, we conducted a multicentre prospective observational study to describe current practice patterns in Canada with respect to the timing of, and indications for, initiation of RRT in critically ill patients with AKI.…”