A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy

Fischer, Berit; Ludders, John W.; Asakawa, Makoto; Fortier, Lisa A.; Fubini, Susan L.; Nixon, Alan J.; Radcliffe, Rolfe M.; Erb, Hollis N.

doi:10.1111/j.1467-2995.2008.00422.x

Cited by 23 publications

(18 citation statements)

References 25 publications

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“…administration, alternate routes of administration for buprenorphine have been investigated. Epidural administration of buprenorphine alone or in combination with other analgesic drugs has been shown to be effective as an analgesic drug; however, there was no clear advantage over epidural morphine in those studies (Natalini et al, 2006;Fischer et al, 2009). Walker (2007) reported the use of sublingual buprenorphine for long-term analgesia in a horse with severe head and neck trauma.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Davis¹,

Messenger²,

LaFevers³

et al. 2011

Vet Pharm & Therapeutics

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The purpose of this study was to determine the pharmacokinetics of buprenorphine following intravenous (i.v.) and intramuscular (i.m.) administration in horses. Six horses received i.v. or i.m. buprenorphine (0.005 mg/kg) in a randomized, crossover design. Plasma samples were collected at predetermined times and horses were monitored for adverse reactions. Buprenorphine concentrations were measured using ultra-performance liquid chromatography with electrospray ionization mass spectrometry. Following i.v. administration, clearance was 7.97±5.16 mL/kg/min, and half-life (T(1/2)) was 3.58 h (harmonic mean). Volume of distribution was 3.01±1.69 L/kg. Following i.m. administration, maximum concentration (C(max)) was 1.74±0.09 ng/mL, which was significantly lower than the highest measured concentration (4.34±1.22 ng/mL) after i.v. administration (P<0.001). Time to C(max) was 0.9±0.69 h and T(1/2) was 4.24 h. Bioavailability was variable (51-88%). Several horses showed signs of excitement. Gut sounds were decreased 10±2.19 and 8.67±1.63 h in the i.v. and i.m. group, respectively. Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg. Signs of excitement and gastrointestinal stasis may be noted.

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Davis¹,

Messenger²,

LaFevers³

et al. 2011

Vet Pharm & Therapeutics

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“…Studies in human beings, rats and horses indeed showed that epidural combinations of α2-adrenergic agonists with morphine potentiate and prolong the analgesic effects of each drug without increasing the side effects (Wilcox and others 1987, Motsch and others 1990, Sysel and others 1996, 1997, Goodrich and others 2002). Fischer and others (2009) showed similar analgesic effects when epidural detomidine in combination with either morphine or buprenorphine was administered in horses that underwent bilateral stifle arthroscopy, although more tachypnoeic horses were observed in the buprenorphine group, which may be associated with either pain or intrinsic characteristics of the drug.…”

Section: Discussionmentioning

confidence: 80%

Continuous caudal epidural analgesia for perioperative pain control after bilateral mastectomy in a mare

Rodrigo-Mocholí

Steblaj

Vlaminck

et al. 2016

Vet Record Case Reports

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An epidural catheter was used to provide perioperative analgesia as part of a multimodal balanced anaesthesia and analgesia in a mare undergoing a bilateral mastectomy. Despite development of severe hypoxaemia during anaesthesia, recovery from anaesthesia was uneventful. Oral administration of a NSAID combined with administration of xylazine and morphine by an epidural catheter resulted in adequate postoperative pain relief, based on assessment of physiological parameters and behaviour. Neither complications nor side effects were observed during hospitalisation.

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“…Methadone provides effective analgesia but with a shorter duration than that reported for morphine (Olbrich and Mosing 2003). In horses undergoing bilateral stifle arthroscopy, epidural buprenorphine plus detomidine produced analgesia of similar intensity and duration to that provided by morphine and detomidine (Fischer et al 2009).…”

Section: Epidural and Subarachnoid Anaesthesia And Analgesiamentioning

confidence: 84%

“…In horses undergoing bilateral stifle arthroscopy, epidural buprenorphine plus detomidine produced analgesia of similar intensity and duration to that provided by morphine and detomidine (Fischer et al . ).…”

Section: Locoregional Techniquesmentioning

confidence: 97%

Perioperative pain management in horses

McFadzean

Love

2018

Equine Veterinary Education

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Summary The inability to talk does not diminish an animal's ability to experience pain, although it may hinder its recognition and therefore lead to the under‐treatment of pain. Pain assessment and treatment in horses has advanced considerably with the recent publication of numerous research papers in this area. This review will summarise these research findings and suggest how advances in knowledge of perioperative pain management can be implemented in equine clinical practice.

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A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy

Cited by 23 publications

References 25 publications

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Continuous caudal epidural analgesia for perioperative pain control after bilateral mastectomy in a mare

Perioperative pain management in horses

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