A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain

Moe, Morten C.; Kolberg, Rebecca; Sandberg, Cecilie; Vik-Mo, Einar O.; Ølstørn, Håvard; Varghese, Mercy; Langmoen, Iver A.; Nicolaissen, Bjørn

doi:10.1016/j.exer.2008.09.020

Cited by 43 publications

(38 citation statements)

References 115 publications

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“…Spheres from PE were similar to the spheres from the ciliary region cells [6], but differed from the cerebral neurospheres by structure and re-inoculation potential [1,14,26]. The expression of Oct4 and Pax6 indicated dedifferentiation of the cells from the spheres under the effect of factors of the medium.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Phenotypic Modifi cation of Pigmented Epithelium Cells from Human Eye at Early Stages of Development

et al. 2009

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Multipotent characteristics of human fetal (9-11.5 weeks) pigmented epithelial retinal cells and capacity to transdifferentiation in neuronal direction were studied in vitro under different culturing conditions. The cultures were analyzed using a wide spectrum of antibodies. It was found that pigmented epithelium of human eye is a heterogeneous cell population with three subtypes differing by adhesion characteristics, migration, transdifferentiation potential, and reaction to microenvironmental factors. Subtype 1 cells steadily retain their epithelial characteristics, subtype 2 cells change their morphotype and produce neuroblast and photoreceptor cell proteins, and subtype 3 cells form free floating spheres and are capable to multipotent differentiation.

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Section: Resultsmentioning

confidence: 99%

In Vitro Phenotypic Modifi cation of Pigmented Epithelium Cells from Human Eye at Early Stages of Development

et al. 2009

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“…On the one hand, it has been shown that most precursor cells in the ciliary margin may give rise to both epithelial cells and neurons [16,17]. On the other hand, it is still controversial whether ciliary epithelial (CE) cells are a residual quiescent group of true stem cells of the optic neuroepithelium, precursory to RPC or whether, instead, CE cells have a capacity to transdifferentiate into RPC [18,19]. Recently, Bhatia et al [20] have identified two distinct populations of RPC in adult human post mortem eyes in retinal explants cultures in two distinct locations:…”

Section: Introductionmentioning

confidence: 99%

Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy

Ducournau

Boscher

Adelman

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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Our observations suggest that EGFR-positive CE cells in the adult human eye in vivo with RD and PVR form "neurosphere-like" structures; their differentiation seems to be directed towards the neural and photoreceptor lineage, and not towards glial formation. In the adult human eye, the CE in a pathological retinal environment such as RD might provide a spontaneous source of donor cells for retinal transplantation.

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“…In some amphibians this capacity is retained in an adult state. In caudated amphibians (Urodela), damage or removal of the retina triggers transdifferentiation of RPE cells into neural and glial cells leading to complete retina reconstruction [13,14].…”

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confidence: 99%

Phenotypic Plasticity of Retinal Pigment Epithelial Cells from Adult Human Eye In Vitro

et al. 2011

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Phenotypic plasticity of retinal pigment epithelial cells from adult human eye was studied by immunohistochemical methods under different culturing conditions. It was found that retinal pigment epithelium in adult human eye is a heterogeneous population of cells demonstrating different behavior in vitro. Some cells retain epithelial morphology for a long time in culture, while others are rapidly transformed into fibroblast-like cells and synthesize proteins typical of proneural, neural, glial, and photoreceptor cells. However, irrespective of initial morphological features differentiation of retinal pigment cells can be modulated by varying culturing conditions.

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A comparison of epithelial and neural properties in progenitor cells derived from the adult human ciliary body and brain

Cited by 43 publications

References 115 publications

In Vitro Phenotypic Modifi cation of Pigmented Epithelium Cells from Human Eye at Early Stages of Development

In Vitro Phenotypic Modifi cation of Pigmented Epithelium Cells from Human Eye at Early Stages of Development

Proliferation of the ciliary epithelium with retinal neuronal and photoreceptor cell differentiation in human eyes with retinal detachment and proliferative vitreoretinopathy

Phenotypic Plasticity of Retinal Pigment Epithelial Cells from Adult Human Eye In Vitro

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