A comparison of fat reduction efficacy using combined non-invasive and minimally invasive laser lipolysis system

Oh, Seokwon; Lee, Ji-Young; Ryu, Hanyoung; Seo, Young-Seok

doi:10.1117/12.2544727

Cited by 1 publication

(2 citation statements)

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“…Through murine experiments, the effect of laser irradiation and spray cooling on the skin tissue can be directly examined, which is of vital importance to study the response of adipose tissue and optimize the therapeutic parameters. Up to now, obesity rats 13 and miniature pig 14,15 had been employed to explore the efficacy and safety of laser lipolysis through visual inspection, measurement of fat layer thickness before and after laser irradiation, temperature measurement of skin surface and internal tissue, histopathological analysis, assessment of adipocyte microstructure and apoptosis-related DNA tests. Among these methods, histopathological analysis can visualize the morphological changes from cell to tissue scale, which is effective to reveal the mechanism of laser lipolysis.…”

Section: Introductionmentioning

confidence: 99%

“…Oh et al 14 inspected the thickness of subcutaneous fat layer in miniature pig by micro‐CT, ultrasound, and histopathological analysis, and compared the lipolysis effect of noninvasive lipolysis by a 1060 nm laser and minimally invasive lipolysis by 1980 nm/2300 nm laser. They suggested that the combination of the two lasers may achieve better lipolysis effect.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological evaluation of the R134a multipulsed spray cooling assisted 1210 nm laser lipolysis by the murine model in vivo

et al. 2022

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Background and Objective Owing to the greater absorption affinity for lipo‐rich tissue than water, the 1210 nm laser is a promising candidate for transcutaneous lipolysis in the near‐infrared band. However, fat reduction is limited because laser therapy may yield thermal injury of normal tissue. A new protocol to incorporate multipulsed cryogen spray cooling is beneficial to improve the lipolysis effect, and the parameters of laser and cooling can be optimized via skin histopathological analysis. Materials and Methods A murine in vivo model of inguinal tissue of SD rats was established to test the effectivity of transcutaneous lipolysis protocol by R134a multipulsed spray cooling assisted 1210 nm laser irradiation. Tissue response of lipolysis with/without cooling 10 days post the treatment was evaluated by histopathological analysis of skin samples stained with hematoxylin–eosin (HE), through which safe and effective parameters for lipolysis were determined. Results From histopathological analysis of the inguinal tissue of SD rats irradiated by the 1210 nm laser alone, the optimal durations are respectively 7 and 3 s (seconds) for low‐dosage (6 W) and high‐dosage (9 W) therapy, with pronounced lipolysis effect and minimum injury of skin tissue. The multipulsed spray cooling by R134a with a pulse duration of 10 ms (milliseconds), a pulse delay of 2000 ms, and a pulse number of 5 can be introduced to assist the 1210 nm laser therapy with a power of 9 W and a duration of 7 s to achieve desirable fat liquefaction while keeping the complete structure of skin tissue as well as esthetic‐related beneficial effects of hair removal and skin rejuvenation. Conclusion Excellent lipolysis effect can be achieved via R134a multipulsed spray cooling assisted high‐dosage 1210 nm laser irradiation with reasonably matched laser and cooling parameters. The protocol is as follows: Start MP‐CSC for one cycle, and then fire the laser with specific power and duration, while keeping MP‐CSC accordingly. This new protocol may promote the safe and effective clinical implement of transcutaneous laser lipolysis in body contouring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%