A comparison of haloperidol, lithium carbonate and their combination in the treatment of mania

Garfinkel, Paul E.; Stancer, Harvey C.; Persad, Emmanuel

doi:10.1016/0165-0327(80)90029-4

Cited by 100 publications

(59 citation statements)

References 28 publications

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“…Antipsychotic drugs investigated were haloperidol in three (22,23,25), olanzapine in one (26), quetiapine in two (21,24) risperidone in two (23,28) and ziprasidone in one (27). All included participants with bipolar disorder according to DSM-IV or DSM-III criteria with the exception of one that used criteria of Feighner (22). All participants were currently manic or with mixed mania; in four studies participants were receiving a mood stabilizer at the time of randomization (23,24,26,28).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Seven compared an antipsychotic drug given as co-therapy with a mood stabilizer with mood-stabilizer monotherapy. There were additional comparisons in two studies, one compared co-therapy with haloperidol alone (22), and the other compared haloperidol cotherapy with a mood-stabilizer monotherapy (23). Two compared different co-therapies (23,25).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Two compared different co-therapies (23,25). Antipsychotic drugs investigated were haloperidol in three (22,23,25), olanzapine in one (26), quetiapine in two (21,24) risperidone in two (23,28) and ziprasidone in one (27). All included participants with bipolar disorder according to DSM-IV or DSM-III criteria with the exception of one that used criteria of Feighner (22).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…We included eight RCTs with 1124 participants (21)(22)(23)(24)(25)(26)(27)(28). Table 1 shows details of the included trials, including the diagnostic criteria used, participant characteristics, dosing regimens, prior treatment, outcome measures, follow-up periods and quality components.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Acute bipolar mania: a systematic review and meta‐analysis of co‐therapy vs. monotherapy

Smith¹,

Cornelius²,

Warnock

et al. 2006

Acta Psychiatr Scand

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Acute bipolar mania: a systematic review and meta-analysis of co-therapy vs. monotherapy Summations• Adjunct treatment with combined antipsychotics and mood stabilizers is more efficacious than mood stabilizers alone.• Combinations of some drugs are less well tolerated than mood-stabilizer monotherapy. Considerations• All studies included subjects who had already failed to respond to mood stabilizers alone.• The quality of study methods and reporting was variable.Smith LA, Cornelius V, Warnock A, Tacchi MJ, Taylor D. Acute bipolar mania: a systematic review and meta-analysis of co-therapy vs. monotherapy.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Acute bipolar mania: a systematic review and meta‐analysis of co‐therapy vs. monotherapy

Smith¹,

Cornelius²,

Warnock

et al. 2006

Acta Psychiatr Scand

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“…Although probably not as efficacious as lithium, 46 antipsychotic agents have a more rapid onset and superior initial control of psychomotor activity during acute manic episodes. 47,48 They are also useful for management of acute psychotic mania, psychotic depression or treatment-refractive bipolar disorder. However, patients with affective disorders may be quite sensitive to induction of EPS and typical antipsychotic agents may precipitate depressive episodes, dysphoria and rapid cycling of mood.…”

Section: Proposed Mechanism Of Action Of Antipsychotic Drugs In Bipolmentioning

confidence: 99%

Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents

Bymaster

Felder

2002

Mol Psychiatry

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The evidence for the involvement of cholinergic muscarinic receptors in mania and depression is reviewed. Small pilot trials with cholinesterase inhibitors and muscarinic agonists suggest that stimulation of muscarinic receptors may produce an antimanic effect, possibly by activation of muscarinic M 4 receptors. It is concluded that it is not likely that currently used mood stabilizers, such as lithium, valproic acid and carbamazepine, work directly through muscarinic receptor mechanisms. Furthermore, the evidence indicates that antipsychotic agents used for mania are working through the common mechanism of antagonism of dopamine D 2 receptors, and interactions with muscarinic receptors do not play a key role. Finally, it is hypothesized that olanzapine has robust antimanic activity, due to blockade of dopamine D 2 receptors and antagonism of other monoaminergic receptors. Olanzapine may normalize mood due to antidepressant-like activities, such as 5-HT 2A receptor antagonism and increasing cortical norepinephrine and dopamine.

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A 12-Week, Double-blind Comparison of Olanzapine vs Haloperidol in the Treatment of Acute Mania

Tohen¹,

Goldberg²,

Arrillaga³

et al. 2003

Arch Gen Psychiatry

199

102

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A comparison of haloperidol, lithium carbonate and their combination in the treatment of mania

Cited by 100 publications

References 28 publications

Acute bipolar mania: a systematic review and meta‐analysis of co‐therapy vs. monotherapy

Acute bipolar mania: a systematic review and meta‐analysis of co‐therapy vs. monotherapy

Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents

A 12-Week, Double-blind Comparison of Olanzapine vs Haloperidol in the Treatment of Acute Mania

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