A comparison of human immunodeficiency virus, hepatitis C virus, hepatitis B virus, and human T‐lymphotropic virus marker rates for directed versus volunteer blood donations to the American Red Cross during 2005 to 2010

Dorsey, Kerri; Moritz, Erin D.; Steele, Whitney R.; Eder, Anne F.; Stramer, Susan L.

doi:10.1111/j.1537-2995.2012.03904.x

Cited by 34 publications

(35 citation statements)

References 24 publications

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“…Indeed, directed blood donors have higher viral marker rates than volunteer donors. 22 Furthermore, as intestinal microbiota have recently been theorized to potentially be involved in the pathogenesis of a number of systemic diseases, rigorously screened, healthy volunteer donors may have advantages, especially for young patients, who may acquire additional risk factors for disease over their lifetime.…”

Section: Current Treatment Guidelines and Methodsmentioning

confidence: 99%

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

et al. 2015

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The community of microorganisms within the human gut (or microbiota) is critical to health and functions with a level of complexity comparable to an organ system. Alterations of this ecology (or dysbiosis) has been implicated in a number of disease states, the prototypical example being Clostridium difficile infection (CDI). Fecal microbiota transplantation (FMT) has been demonstrated to durably alter the gut microbiota of the recipient and has shown efficacy in the treatment of recurrent CDI. There is hope that FMT may eventually prove beneficial for treatment of other disease associated with alterations in gut microbiota, such as inflammatory bowel disease, irritable bowel syndrome and the metabolic syndrome, to name a few. Although the basic principles that underlie the mechanisms by which FMT demonstrates therapeutic efficacy in CDI are becoming apparent, further research is needed to understand the possible role of FMT in these other conditions. Though relatively simple to perform, questions regarding both short- and long-term safety, as well as the complex and rapidly evolving regulatory landscape has limited widespread utilization. Future work will focus on establishing best practices and more robust safety data than exist currently, as well as refining FMT beyond current “whole stool” transplants to increase safety and tolerability. Encapsulated formulations, full spectrum stool-based products and defined microbial consortia are all in the immediate future.

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Section: Current Treatment Guidelines and Methodsmentioning

confidence: 99%

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

et al. 2015

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“…Our results indicate that "cheaper" qualitative ID-NAT may provide an alternative cost-effective community-based screening technology for AHI in similar populations of MSM with an HIV prevalence >0.4%. The potential detection of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in persons at risk for HIV represents an additional benefit of the EarlyTest algorithm, as the Procleix Ultrio assay, which is used for HIV NAT screening, may also detect proportions of HBV and HCV infections [14,15].…”

Section: Discussionmentioning

confidence: 99%

“…Detection of p24 Ag by the ARCHITECT Ag/Ab Combo assay is currently the most widely used approach for detecting AHI [8][9][10][11][12][13]. Alternative approaches for detecting and differentiating p24 Ag and HIV Ab include the rapid Alere Determine HIV-1/2 Combo assay and more sensitive HIV-1 nucleic acid amplification tests (NATs) [14,15].…”

mentioning

confidence: 99%

Costs per Diagnosis of Acute HIV Infection in Community-based Screening Strategies: A Comparative Analysis of Four Screening Algorithms

Hoenigl

Graff-Zivin

2015

Clinical Infectious Diseases

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Background. In nonhealthcare settings, widespread screening for acute human immunodeficiency virus (HIV) infection (AHI) is limited by cost and decision algorithms to better prioritize use of resources. Comparative cost analyses for available strategies are lacking.Methods. To determine cost-effectiveness of community-based testing strategies, we evaluated annual costs of 3 algorithms that detect AHI based on HIV nucleic acid amplification testing (EarlyTest algorithm) or on HIV p24 antigen (Ag) detection via Architect (Architect algorithm) or Determine (Determine algorithm) as well as 1 algorithm that relies on HIV antibody testing alone (Antibody algorithm). The cost model used data on men who have sex with men (MSM) undergoing community-based AHI screening in San Diego, California. Incremental cost-effectiveness ratios (ICERs) per diagnosis of AHI were calculated for programs with HIV prevalence rates between 0.1% and 2.9%.Results. Among MSM in San Diego, EarlyTest was cost-savings (ie, ICERs per AHI diagnosis less than $13.000) when compared with the 3 other algorithms. Cost analyses relative to regional HIV prevalence showed that EarlyTest was cost-effective (ie, ICERs less than $69.547) for similar populations of MSM with an HIV prevalence rate >0.4%; Architect was the second best alternative for HIV prevalence rates >0.6%.Conclusions. Identification of AHI by the dual EarlyTest screening algorithm is likely to be cost-effective not only among at-risk MSM in San Diego but also among similar populations of MSM with HIV prevalence rates >0.4%.

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“…The most recent estimate for the Southeastern and Northeastern regions of Brazil in 2007-2008 was 92.2 per 100.000 the first time blood donors (Sabino et al 2012). These figures are considerably higher than the USA HIV prevalence per 100.000 blood donors of 2.9 in 2010 (Dorsey et al, 2013) and 4.0 in 2008 (Zou et al, 2012).…”

Section: Resultsmentioning

confidence: 67%

Seroprevalence, Demographic and Blood Donation Characteristics of Blood Donors in the Santa Catarina State, Brazil

Kupek

2014

JMED

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There is a paucity of publications on regional variations in seroprevalence of infectious diseases in blood donors within Brazilian states, so that suitable time trends can be derived for major demographic groups.A population study of blood donors in the southern state of Santa Catarina, Brazil, was conducted using all computerized records of the blood donors submitted to serologic screening in 2010. The subjects were predominantly male (57.8%), aged 18-25 years (33.5%), did not direct their donation to any specific recipient (55.6%), nor did they provide another blood donation in last 12 months (58.6%). The highest seroprevalence was observed for the hepatitis B markers (3.0% for anti-HBc and 0.2% for HBsAg), followed by those for syphilis (0, 08% VDRL), HIV-1 (0.06%), hepatitis C (0.05%), HTLV1/2 (0.01%) and Chagas disease (0.01%). The risk factors associated with higher seroprevalence were associated with the first time donation, being male and of older age. Large regional variations were observed, with the Far West region reaching 7% of anti-HBc and 0.5% of HBsAg positive, and the Midwest region showing 0.1% HIV-positive donors.Hepatits B markers of both lifetime and recent infection reached a high level among blood donor candidates in Santa Catarina in 2010 and remain the foremost serological deferral criterion, despite some evidence of the reduced transmission rate compared to the beginning of the decade. The seroprevalence of other sexually transmitted infections (HIV, syphilis) also persisted on a level too high for a blood donor population, implying even higher prevalence in the general population.

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A comparison of human immunodeficiency virus, hepatitis C virus, hepatitis B virus, and human T‐lymphotropic virus marker rates for directed versus volunteer blood donations to the American Red Cross during 2005 to 2010

Cited by 34 publications

References 24 publications

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

Costs per Diagnosis of Acute HIV Infection in Community-based Screening Strategies: A Comparative Analysis of Four Screening Algorithms

Seroprevalence, Demographic and Blood Donation Characteristics of Blood Donors in the Santa Catarina State, Brazil

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