A comparison of in vitro fertilization results after embryo transfer after 2, 3, and 4 days of embryo culture

Huisman, Gerritdina J.; Alberda, Albert Th.; Leerentveld, Robert A.; Verhoeff, Arie; Zeilmaker, G. H.

doi:10.1016/s0015-0282(16)56715-6

Cited by 61 publications

(26 citation statements)

References 3 publications

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“…Day 4 embryo transfer (ET) was reported in 1994 [14] but mostly limited to cases that were undergoing preimplantation genetic diagnosis on day 3 [15,16]. According to the results of a retrospective study that analyzed the outcomes in patients with all 'good' embryos [17], day 4 ET achieved a significantly higher implantation rate compared to day 3 ET (46.4 vs. 21.4%, p<0.01), while the number of embryos transferred on day 4 was significantly lower than day 3.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcomes of elective single morula embryo transfer versus elective single blastocyst embryo transfer in IVF-ET

Kang

Lee

Jeong

et al. 2012

J Assist Reprod Genet

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Purpose To compare the clinical outcomes of elective single morula embryo transfer (eSMET) versus elective single blastocyst embryo transfer (eSBET) in selected patients. Methods This study was a retrospective study which analyzed for 271 cycles in women under 37 years of age who are undergoing their first or second trial of in vitro fertilization-embryo transfer (IVF-ET) from January 2008 to December 2009. The eSMET was performed on day 4 (n0130) and the eSBET was conducted on day 5 (n0141). Results The clinical pregnancy rate (51.5% vs. 51.8%, p0 0.97), implantation rate (52.3% vs. 52.5%, p00.98), and live birth rate (39.2% vs. 44.7%, p00.36) were similar in the eSMET and eSBET groups, respectively. The miscarriage rate of the eSMET group (23.9%) was slightly higher than that of the eSBET group (13.7%) (p00.12), without reaching statistical significance. There was only one case of monozygotic twin pregnancy in each group. ConclusionsThe clinical outcomes of day 4 eSMET were comparable to those of day 5 eSBET. Therefore, day 4 eSMET is a viable option or an alternative to day 5 eSBET, with no difference in success rates.

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Section: Introductionmentioning

confidence: 99%

Clinical outcomes of elective single morula embryo transfer versus elective single blastocyst embryo transfer in IVF-ET

Kang

Lee

Jeong

et al. 2012

J Assist Reprod Genet

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“…A prospective, randomized study showed no difference in pregnancy outcomes when 2-, 3-, and 4-day transfers were compared (1). Furthermore, no difference in success rates were seen between transfer on days 3 or 5 in another study (2).…”

Section: Introductionmentioning

confidence: 99%

“…To test the benefit of early ET, we initiated a study to determine whether pronuclear uterine transfer 1 day after oocyte retrieval was more effective than transferring cleaving embryos on day 2. 1 Presented at the 53rd Annual Meeting of the American Society for Reproductive Medicine, Cincinnati, Ohio, October 18-22, 1997.…”

Section: Introductionmentioning

confidence: 99%

Pronuclear Uterine Transfer Lowers In Vitro Fertilization Success

Hurst

Tucker

Awoniyi

et al. 1997

Fertility and Sterility

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“…However, conventionally, in most programs offering in vitro fertilization (IVF), 4~8 cell stage embryos are quickly placed in the uterus [1,3]. This asynchrony of embryonic stage and preparation of uterine endometrium may be one major contributory cause of increased abortion and low take-home baby rates in infertility patients [2][3][4].…”

mentioning

confidence: 99%

Comparison of Blastulation and Pregnancy Rates of Fertilized Human Oocytes Obtained after Conventional In Vitro Fertilization and Intracytoplasmic Sperm Injection.

et al. 2000

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Abstract:A comparison was made of good quality blastocysts obtained after either conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). After IVF or ICSI, fertilized oocytes were kept in culture for a further 5 to 7 days before embryo transfer (ET) or embryo freezing. No differences were found in the number of oocytes showing two-pronuclei between conventional IVF (76.9%) and ICSI groups (85.1%). A cohort of 60 and 74 oocytes in the pronuclear stage were cultured after IVF and ICSI, respectively. The number of fertilized oocytes reaching the blastocyst stage was significantly higher (P<0.05) in the IVF group (73.3%) than in the ICSI group (56.8%). A total of 86 blastocysts were categorized into three grades depending on their morphology. The number of blastocyst embryos achieving blastocyst grade 1 (BG1) was significantly higher (P<0.05) in the IVF group than in the ICSI group, 63.3% and 13.5%, respectively. In the IVF group, 10.0% and 0% of 2PN oocytes developed to BG2 and BG3, and 2.7% and 4.1% in the ICSI group, respectively, with no significant differences between the two groups. Pregnancy rate was higher in the IVF group than in the ICSI group, 50% and 20%, respectively. It was concluded that fertilized oocytes resulting from ICSI cannnot be successfully cultured for 5-7 days for blastulation and blastocyst-ET.

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A comparison of in vitro fertilization results after embryo transfer after 2, 3, and 4 days of embryo culture

Cited by 61 publications

References 3 publications

Clinical outcomes of elective single morula embryo transfer versus elective single blastocyst embryo transfer in IVF-ET

Clinical outcomes of elective single morula embryo transfer versus elective single blastocyst embryo transfer in IVF-ET

Pronuclear Uterine Transfer Lowers In Vitro Fertilization Success

Comparison of Blastulation and Pregnancy Rates of Fertilized Human Oocytes Obtained after Conventional In Vitro Fertilization and Intracytoplasmic Sperm Injection.

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