A Comparison of International Normalized Ratio Results by Point-of-Care Device and Clinical Laboratory Analyzers in a Vascular Surgery Department

Alserr, Ayman H. K.; Menshawey, Rahma; Kotb, Ahmed N; Hussein, Nourhan; Kotp, Noha; Ashraf-Taha, Mahmoud; Anwar, Nouran; Abdalla, Asmaa; Abdullah, Menna; Ela, Shaimaa Abol; Khairy, Hussein

doi:10.1097/poc.0000000000000213

Cited by 2 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Blood obtained from a finger puncture is placed onto strips containing a thrombin-specific electrogenic substrate, which releases the redox-active molecule when thrombin encounters the substrate, which is connected to a portable device that analyses the PT/INR values. Several studies utilised a Coagucheck XS coagulation analyser for the INR measurement of warfarin and LMWH [46][47][48][49]. Similarly, i-STAT (Abbott Diagnostics, Macquarie Park, Australia) and the Xprecia Stride coagulation analyser (Siemens Healthcare Diagnostics, Macquarie Park, Australia) also use a similar electrochemical platform [50][51][52][53].…”

Section: Electrochemical Sensors For Anticoagulants Using Thrombin-sp...mentioning

confidence: 99%

Electrochemical Monitoring in Anticoagulation Therapy

Mruthunjaya,

Torriero

2024

Molecules

View full text Add to dashboard Cite

The process of blood coagulation, wherein circulating blood transforms into a clot in response to an internal or external injury, is a critical physiological mechanism. Monitoring this coagulation process is vital to ensure that blood clotting neither occurs too rapidly nor too slowly. Anticoagulants, a category of medications designed to prevent and treat blood clots, require meticulous monitoring to optimise dosage, enhance clinical outcomes, and minimise adverse effects. This review article delves into the various stages of blood coagulation, explores commonly used anticoagulants and their targets within the coagulation enzyme system, and emphasises the electrochemical methods employed in anticoagulant testing. Electrochemical sensors for anticoagulant monitoring are categorised into two types. The first type focuses on assays measuring thrombin activity via electrochemical techniques. The second type involves modified electrode surfaces that either directly measure the redox behaviours of anticoagulants or monitor the responses of standard redox probes in the presence of these drugs. This review comprehensively lists different electrode compositions and their detection and quantification limits. Additionally, it discusses the potential of employing a universal calibration plot to replace individual drug-specific calibrations. The presented insights are anticipated to significantly contribute to the sensor community’s efforts in this field.

show abstract

Section: Electrochemical Sensors For Anticoagulants Using Thrombin-sp...mentioning

confidence: 99%

Electrochemical Monitoring in Anticoagulation Therapy

Mruthunjaya,

Torriero

2024

Molecules

View full text Add to dashboard Cite

show abstract

“…Blood obtained from a finger puncture is placed onto strips containing thrombin-specific electrogenic substrate, which releases the redox active molecule when thrombin encounters the substrate, which is connected to a portable device that analyses PT/INR values. Several studies utilised a Coagucheck XS coagulation analyser for the INR measurement of warfarin and LMWH [46][47][48][49]. Similarly, i-STAT (Abbott Diagnostics) and Xprecia Stride coagulation analyser (Siemens Healthcare Diagnostics) also use a similar electrochemical platform [50][51][52][53].…”

Section: Electrochemical Sensors For Anticoagulants Using Thrombin-sp...mentioning

confidence: 99%

Electrochemical Monitoring on Anticoagulation Therapy

Mruthunjaya,

Torriero

2024

Preprint

View full text Add to dashboard Cite

The process of blood coagulation, wherein circulating blood transforms into a clot in response to internal or external injury, is a critical physiological mechanism. Monitoring this coagulation process is vital to ensure that blood clotting occurs neither too rapidly nor too slowly. Anticoagulants, a category of medications designed to prevent and treat blood clots, require meticulous monitoring to optimise dosage, enhance clinical outcomes, and minimise adverse effects. This review article delves into the various stages of blood coagulation, explores commonly used anticoagulants and their targets within the coagulation enzyme system, and emphasises the electrochemical methods employed in anticoagulant testing. Electrochemical sensors for anticoagulant monitoring are categorised into two types. The first type focuses on assays measuring thrombin activity via electrochemical techniques. The second type involves modified electrode surfaces that either directly measure the redox behaviour of anticoagulants or monitor the response of standard redox probes in the presence of these drugs. The review provides a comprehensive list of different electrode compositions and their detection and quantification limits. Additionally, it discusses the potential of employing a universal calibration plot to replace individual drug-specific calibrations. The insights presented are anticipated to significantly contribute to the sensor community's efforts in this field.

show abstract

A Comparison of International Normalized Ratio Results by Point-of-Care Device and Clinical Laboratory Analyzers in a Vascular Surgery Department

Cited by 2 publications

References 32 publications

Electrochemical Monitoring in Anticoagulation Therapy

Electrochemical Monitoring in Anticoagulation Therapy

Electrochemical Monitoring on Anticoagulation Therapy

Contact Info

Product

Resources

About