A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo

Popov, Todor A.; Dumitraşcu, Dinu Iuliu; Bachvarova, A.; Bocşan, Ioana Corina; Dimitrov, Vasil; Mk, Church

doi:10.1007/s00011-006-0075-z

Cited by 42 publications

(25 citation statements)

References 19 publications

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“…The obtained laser results using laser Doppler scanning are consistent with results of other studies in which cetirizine with loratadine, or their optic isomers (levocetirizine with desloratadine) were similarly compared (Van Neste et al, 1992;1993;Klos et al, 2006;Popov, 2006). In these studies, like in our trial, the effect of levocetirizine was more stable and predictable.…”

Section: Figsupporting

confidence: 91%

H1-antihistamines suppress wheal-and-flare reaction and skin blood perfusion measured by Laser Dopppler flowmetry: randomized, double-blind, placebo-controlled, crossover design study

Bukovskis¹,

Tirzīte²,

Strazda³

et al. 2010

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Section: Figsupporting

confidence: 91%

H1-antihistamines suppress wheal-and-flare reaction and skin blood perfusion measured by Laser Dopppler flowmetry: randomized, double-blind, placebo-controlled, crossover design study

Bukovskis¹,

Tirzīte²,

Strazda³

et al. 2010

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…Simons изуча-лись концентрации в крови и коже (при биопсии) и пода-вление образования кожных реакций в гистамин-инду- Примечание. Адаптировано по ссылкам [45][46][47][48][49][50][51][52][53][54][55][56].…”

Section: -е поколение (метаболиты препаратов 2-го поколения)unclassified

Antihistamines in Treatment of Chronic Urticaria. Review of Modern Recommendations

Леонова¹,

Дворников²,

Скрипкина³

et al. 2016

Med. sov.

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“…Although receptor occupancy for these drugs appears to correlate with pharmacodynamic activity in skin wheal and flare studies and with efficacy in allergen challenge chamber studies,[33,34] are the differences relevant in clinical practice? Studies in allergic rhinitis suggest that the above 3 drugs are of similar effectiveness[35,36].…”

Section: Second-generation H1-antihistaminesmentioning

confidence: 99%

Pharmacology of Antihistamines

Church¹,

Church²

2011

World Allergy Organization Journal

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This article reviews the molecular biology of the interaction of histamine with its H1-receptor and describes the concept that H1-antihistamines are not receptor antagonists but are inverse agonists i.e. they produce the opposite effect on the receptor to histamine. It then discourages the use of first-generation H1-antihistamines in clinical practice today for two main reasons. First, they are less effective than second generation H1-antihistamines. Second, they have unwanted side effects, particularly central nervous system and anti-cholinergic effects, and have the potential for causing severe toxic reactions which are not shared by second-generation H1-antihistamines. There are many efficacious and safe second-generation H1-antihistamines on the market for the treatment of allergic disease. Of the three drugs highlighted in this review, levocetirizine and fexofenadine are the most efficacious in humans in vivo. However, levocetirizine may cause somnolence in susceptible individuals while fexofenadine has a relatively short duration of action requiring twice daily administration for full all round daily protection. While desloratadine is less efficacious, it has the advantages of rarely causing somnolence and having a long duration of action. Lastly, all H1-antihistamines have anti-inflammatory effects but it requires regular daily dosing rather than dosing 'on-demand' for this effect to be clinically demonstrable.

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A comparison of levocetirizine and desloratadine in the histamine-induced wheal and flare response in human skin in vivo

Abstract: Levocetirizine is significantly more effective than desloratadine in inhibiting wheal and flare responses to histamine in human skin in vivo, with 1.25 mg levocetirizine being more effective than 10 mg desloratadine.

Cited by 42 publications

References 19 publications

H1-antihistamines suppress wheal-and-flare reaction and skin blood perfusion measured by Laser Dopppler flowmetry: randomized, double-blind, placebo-controlled, crossover design study

H1-antihistamines suppress wheal-and-flare reaction and skin blood perfusion measured by Laser Dopppler flowmetry: randomized, double-blind, placebo-controlled, crossover design study

Antihistamines in Treatment of Chronic Urticaria. Review of Modern Recommendations

Pharmacology of Antihistamines

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