A comparison of locoregional depot and systemic preparations of 9-aminocamptothecin for treatment of liver metastases in a rat tumor model: Superior antitumor activity of sustained-release preparation

Dookeran, Keith A.; Brumfield, Ann; Rubin, Joshua T.

doi:10.1007/bf02303587

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…135 Intraarterial chemotherapy, however, can increase the exposure time and the local concentrations of chemo-agents while reducing systemic toxicity. [136][137][138][139][140] Therefore, locoregional chemotherapy theoretically provides locoregional lymphodepletion with less toxicity, resulting in good CAR T cell response with patients, especially those who are sensitive to fludarabine. Regional adjuvant cytokine delivery and lymphodepletion potentially activate CAR T cells and inactivate immunosuppressive cells.…”

Section: Adjuvant Strategies For Car T Cells Via Interventional Oncology Techniquesmentioning

confidence: 99%

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Kawakami

Ghosn

Cheema

et al. 2022

Molecular Therapy - Oncolytics

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Adoptive cell therapy with chimeric antigen receptors (CAR) T cells has proven effective for hematologic malignancies, but success in solid tumors has been impeded by poor intratumoral infiltration, exhaustion of effector cells from antigen burden, and an immunosuppressive tumor microenvironment. Results from recent clinical trials and preclinical studies lend promising evidence of locoregional approaches for CAR T cell delivery, priming the tumor microenvironment, and performing adjuvant therapies that sustain T cell activity. Interventional oncology is a subspeciality of interventional radiology where imaging guidance is used to perform percutaneous and catheter-directed procedures for localized, non-surgical therapy or interrogation of solid tumors. Interventional oncology provides unique synergies with immunotherapy, which has been well-studied to improve treatment efficacy while reducing toxicities associated with systemic treatment. Besides aiding in CAR T cell delivery, priming, or the stimulation of the tumor microenvironment to promote effector survival and function, interventional oncology can also aid in the monitoring of treatment response through selective, multiplex tumor sampling and catheter-based venous sampling. This review presents an overview of interventional oncology, its various procedures, and its potential for advancing CAR T cell immunotherapy of solid tumors.

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Section: Adjuvant Strategies For Car T Cells Via Interventional Oncology Techniquesmentioning

confidence: 99%

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Kawakami

Ghosn

Cheema

et al. 2022

Molecular Therapy - Oncolytics

View full text Add to dashboard Cite

show abstract

A comparison of locoregional depot and systemic preparations of 9-aminocamptothecin for treatment of liver metastases in a rat tumor model: Superior antitumor activity of sustained-release preparation

Abstract: These results suggest that locoregional therapy of hepatic neoplasms with 9-AC/Ethiodol would be associated with clinical efficacy far exceeding that associated with its systemic administration.

Cited by 1 publication

References 14 publications

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

Expanding the role of interventional oncology for advancing precision immunotherapy of solid tumors

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