A comparison of maternal serum levels of endothelial nitric oxide synthase, asymmetric dimethylarginine, and homocysteine in normal and preeclamptic pregnancies

Laskowska, Marzena; Laskowska, Katarzyna; Terbosh, Mahfoz; Oleszczuk, Jan

doi:10.12659/msm.883932

“…The low NO ∙ levels observed in preeclampsia compared to healthy normotensive pregnancy in this study could be as a result of the endogenous inhibition of eNOS by ADMA. Consistent with previous findings [ 17 , 23 , 29 – 32 ], this study reports elevated ADMA in preeclamptic women ( Table 1 ). Other studies [ 33 – 35 ], however, observed unchanged ADMA levels in preeclamptic women compared to normotensive pregnancy.…”

Section: Discussionsupporting

confidence: 93%

Altered Bioavailability of Nitric Oxide and L‐Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia

Tashie

¹

,

Fondjo

²

,

Owiredu

³

et al. 2020

BioMed Research International

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Background. Preeclampsia is a major cause of maternal and neonatal morbidity and mortality in sub-Saharan Africa. Evidence indicates that endothelial dysfunction is central to the pathogenesis of preeclampsia. This study assessed the level of the components of the arginine-nitric oxide pathway to evaluate endothelial dysfunction in normotensive pregnancies and pregnancies complicated with preeclampsia. Methods. This case-control study was conducted among pregnant women who visited Comboni Hospital from January 2017 to May 2018. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Sociodemographic, clinical, and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of nitric oxide (NO∙), L-arginine, asymmetric dimethylarginine (ADMA), and 3-nitrotyrosine using an enzyme-linked immunosorbent assay technique. Results. The mean NO∙ ( p = 0.010 ) and L-arginine/ADMA ratio ( p < 0.0001 ) was significantly lower in PE compared to NP while mean L-arginine ( p = 0.034 ), ADMA ( p < 0.0001 ), and 3-nitrotyrosine ( p < 0.0001 ) were significantly higher in PE than NP. ADMA showed a significant positive association with systolic blood pressure ( β = 0.454 , p = 0.036 ) in severe PE. Women with PE had significant intrauterine growth restriction ( p < 0.0001 ) and low birth weight infants ( p < 0.0001 ) when compared to NP. Conclusion. Preeclampsia is associated with reduced NO∙ bioavailability, L-arginine/ADMA ratio, and elevated levels of ADMA and 3-nitrotyrosine. Measurements of the levels of these parameters can help in the early prediction of endothelial dysfunction in preeclampsia. Exogenous therapeutic supplementation with L-arginine during pregnancy to increase the L-arginine/ADMA ratio should be considered to improve endothelial function in preeclampsia and pregnant women at risk of developing preeclampsia.

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“…Results obtained through statistical analysis showed the incidence of EOPE occured earlier. The findings did not fit when compared to previous studies that said that the EOPE occured in pregnancy < 34 week [10]- [13]. Shallow trophoblast invasion and spiral artery remodeling disorder is a fundamental pathophysiology of the EOPE.…”

Section: Discussioncontrasting

confidence: 98%

“…Preeclampsia can occur ≥34 weeks pregnancy or can be called a late onset preeclampsia (LOPE) [10]- [13]. However, approximately 10% of cases of PE occur <34 week of pregnancy so-called early-onset preeclampsia (EOPE).…”

Section: Introductionmentioning

confidence: 99%

The Correlation between Mothers with Low Birth Weight History and Body Mass Index Leptin Levels, and Preeclampsia

Aziz¹,

Mose²,

Deborah³

2015

OALib

0

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Preeclampsia (PE) is one of the complications of pregnancythat significantly increases maternal and fetal mortality and morbidity. Mothers who were born as low birth weight (LBW) babies have risks for PE that are 2 -3 times higher than maternal birth weight ≥ 2500 g. LBW history of the mother is also correlates with the incidence of metabolic syndrome later in life including incresed of body mass index (BMI), hyperlipidemia, hypertension, stroke type 2 diabetes and cardiovascular accident (CVA). This study aimed at assessing the correlation between the incidence of LBW history of the mother with PE, BMI and leptin levels. This study was a retrospective study of maternal LBW history with case control design as well as cross-sectional design to search the correlation between BMI and leptin levels with the incidence of PE. This study was conducted from December 2014 through February 2015 in Hasan Sadikin Hospital Bandung. Data were analyzed using Spearman Rank and Chi-Square, and the significant difference was determined as α < 0.05. The results showed that maternal LBW history correlated with an increased in systolic (r = −0.417; p = 0.017) and diastolic (r = −0.498; p = 0.004) blood pressure but did not correlated with the incidence of PE (r = 0.333; p = 0.127). The incidence of maternal history of LBW was higher in cases of PE (p = 0.033). There was a correlation between LBW history and early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) (r = 0.500; p = 0.048). There was no correlation between LBW history of BMI (r = −0.040; p = 0.830) and levels of leptin (r = −0.157; p = 0.390). There was a correlation of BMI and leptin levels (r = 0.664; p = 0.0001) Maternal LBW history was correlated with increased incidence of systolic and diastolic blood pressure and the incidence of EOPE and LOPE.

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“…The ADMA that accumulates in HHcy results in uncoupling of eNOS, reducing levels of NO and impairing NO bioavailability. 30 Further products of peroxynitrite would induce endothelial dysfunction and thrombogenesis. Moreover, peroxynitrite in turn may cause further uncoupling of NOS.…”

Section: Discussionmentioning

confidence: 99%

Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease

Liu

¹

,

Yang

²

,

Peng

³

et al. 2015

SMJ

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Objectives:To study the associations between hyperhomocysteinemia (HHcy) and the severity of coronary heart disease (CHD).Methods:We retrospectively analyzed metabolic parameters, anthropometric variables, and life style habits in 292 CHD patients of different categories, and 100 controlled non-CHD patients with chest pain symptoms who were hospitalized in the Department of Cardiovascular Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, China between October 2013 and September 2014.Results:The prevalence of HHcy in CHD patients was 79.1%, while only 5% of non-CHD patients had elevated serum homocysteine (Hcy) concentrations. The prevalence of HHcy significantly increased from 5% in non-CHD controls to 66% in the stable angina pectoris (SAP) group, to 81.9% in the unstable angina pectoris group, and to 93.15% in the acute myocardial infarction (AMI) group (p<0.001). After adjusting for confounding factors, multivariate logistic regression analysis showed that HHcy was independently associated with CHD category (AMI versus SAP, odds ratio [6.38], 95% confidence interval; 1.18-34.46). The Hcy was negatively correlated with folic acid (r=-0.67, p<0.001) and vitamin B12 (r=-0.56, p<0.001). Of the CHD patients with HHcy, 51.1% had low folic acid and 42% had low vitamin B12, 7 or 5 times higher than that of CHD patients with normal-low Hcy concentrations (p<0.001).Conclusion:Hyperhomocysteinemia is independently associated with the severity of CHD, and significantly correlated with low status of folic acid and vitamin B12 in CHD patients.

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A comparison of maternal serum levels of endothelial nitric oxide synthase, asymmetric dimethylarginine, and homocysteine in normal and preeclamptic pregnancies

Cited by 31 publications

References 43 publications

Altered Bioavailability of Nitric Oxide and L‐Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia

Altered Bioavailability of Nitric Oxide and L‐Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia

The Correlation between Mothers with Low Birth Weight History and Body Mass Index Leptin Levels, and Preeclampsia

Hyperhomocysteinemia as a metabolic disorder parameter is independently associated with the severity of coronary heart disease

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