Journal of Virological Methods

2016

DOI: 10.1016/j.jviromet.2016.02.005

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A comparison of methods for extracting influenza viral titer characteristics

Gilberto González-Parra

¹

,

Thalia Rodriguez

²

,

Hana M. Dobrovolny

³

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Cited by 4 publications

References 58 publications

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Mathematical modeling and numerical simulations of Zika in Colombia considering mutation

¹

,

González-Parra

²

,

³

2019

Mathematics and Computers in Simulation

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Mathematical modeling and numerical simulations of Zika in Colombia considering mutation

¹

,

González-Parra

²

,

³

2019

Mathematics and Computers in Simulation

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No abstract

A quantitative assessment of dynamical differences of RSV infections in vitro and in vivo

González-Parra

¹

,

²

2018

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Experimental results in vitro and in animal models are used to guide researchers in testing vaccines or treatment in humans. However, viral kinetics are different in vitro, in animals, and in humans, so it is sometimes difficult to translate results from one system to another. In this study, we use a mathematical model to fit experimental data from multiple cycle respiratory syncytial virus (RSV) infections in vitro, in african green monkey (AGM), and in humans in order to quantitatively compare viral kinetics in the different systems. We find that there are differences in viral clearance rate, productively infectious cell lifespan, and eclipse phase duration between in vitro and in vivo systems and among different in vivo systems. We show that these differences in viral kinetics lead to different estimates of drug effectiveness of fusion inhibitors in vitro and in AGM than in humans.

Quantifying rotavirus kinetics in the REH tumor cell line using in vitro data

González-Parra

¹

,

²

,

³

et al. 2018

Virus Research

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