A comparison of methods for meta‐analysis of a small number of studies with binary outcomes

Mathes, Tim; Kuß, Oliver

doi:10.1002/jrsm.1296

Cited by 94 publications

(87 citation statements)

References 47 publications

(190 reference statements)

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“…Data from this analysis should be interpreted carefully as the low number of studies makes the estimation of heterogeneity difficult and the result can be biased …”

Section: Resultsmentioning

confidence: 99%

The association between digital screen time and myopia: A systematic review

Lança

Saw

2020

Ophthalmic Physiologic Optic

176

146

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Purpose Digital screen time has been cited as a potential modifiable environmental risk factor that can increase myopia risk. However, associations between screen time and myopia have not been consistently reported. Although myopia prevalence increased before the massive use of digital devices in some countries, with the rise being influenced by education, there may be an added recent effect of screen time. The aim of this systematic review is to determine the association between screen time and the risk of developing (1) prevalent or incident myopia, or (2) the risk of myopia progression in children. Published manuscripts were identified in PubMed, ScienceDirect and the Cochrane Library, and citation lists were reviewed. Recent findings Fifteen studies were included (nine cross‐sectional and six cohort studies) with a total of 49 789 children aged between 3 and 19 years old. Seven studies found an association between screen time and myopia. The results showed mixed evidence with the more recent studies exposing a trend of association between hours spent by children using screens and myopia. Meta‐analysis using a random‐effects model was performed in five studies (n = 20 889) that reported odds ratio (OR). The I2 statistics was used to assess heterogeneity. A pooled OR of 1.02 (95% CI: 0.96–1.08; p = 0.48) suggests that screen time is not associated with prevalent and incident myopia in this group of five studies. Summary The results for screen time and myopia are mixed. Further studies with objective screen time measurements are necessary to assess evidence of an association between screen time and myopia.

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“…Data from this analysis should be interpreted carefully as the low number of studies makes the estimation of heterogeneity difficult and the result can be biased …”

Section: Resultsmentioning

confidence: 99%

The association between digital screen time and myopia: A systematic review

Lança

Saw

2020

Ophthalmic Physiologic Optic

176

146

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“…The main analysis was the pooled prevalence along with its 95% confidence interval (CI) of Ph-like ALL among patients with ALL across the studies, which was calculated by the DerSimonian and Laird random-effects model with double arcsine transformation. 25 The same technique was also used to calculate several secondary outcomes, including the pooled 5-year OS rate, DFS rate, EFS rate, and CIR rate of Ph-like ALL patients across the studies. Comparative analyses of the odds of surviving at 5 years, experiencing DFS at 5 years, experiencing EFS at 5 years, and having at least one relapse at 5 years among Ph-like ALL, Ph þ ALL, and B-other ALL patients were also conducted by the Mantel-Haenszel method.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Clinical Outcome of Philadelphia-Like Acute Lymphoblastic Leukemia: Systematic Review and Meta-analysis

Owattanapanich

Rujirachun

Ungprasert

et al. 2020

Clinical Lymphoma Myeloma and Leukemia

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Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) has disease phenotypes similar to Ph D ALL. This meta-analysis aimed to include cohort study of patients with ALL who reported the prevalence of Ph-like ALL. Across the 15 included studies, the most common gene subgroup was CRLF2 gene rearrangement, and the peak prevalence of Ph-like ALL occurred in adolescents and young adults. Background: The presence of Philadelphia (Ph)-like ALL among patients with acute lymphoblastic leukemia (ALL) may indicate a poor prognosis similar to Ph þ ALL, although the data are still inconclusive and the prevalence of Ph-like ALL varied considerably across studies. Patients and Methods: We performed a systematic review and meta-analysis in order to identify all cohort studies of patients with ALL that reported the prevalence of Ph-like ALL and to summarize their results together. The pooled prevalence and rate were calculated by the DerSimonian-Laird random-effect model with double arcsine transformation. Results: Across the 15 included studies describing 11,040 ALL patients, the peak prevalence of the presence of Ph-like ALL among patients with ALL was between ages 11 and 40 years, where the pooled prevalence was 25.8% to 26.2%. The pooled 5-year overall survival rate of Ph-like ALL was 42.8% (95% confidence interval, 23.9-64.1; I 2 93%). Comparative analysis with Bother ALL patients was conducted by the Mantel-Haenszel method; it found that Ph-like ALL patients had a significantly lower chance of being alive at 5 years (pooled odds ratio, 0.35; 95% confidence interval, 0.25-0.50; P < .00001, I 2 ¼ 40%). The chance of Ph-like ALL patients surviving at 5 years was similar to Ph-positive ALL patients (pooled odds ratio, 0.72; 95% confidence interval, 0.26-2.02; P ¼ .53, I 2 ¼ 77%). Conclusion: Ph-like ALL is not uncommon among ALL patients, and its presence is associated with an unfavorable outcome. More investigations are needed for better therapeutic options.

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“…For remission incidence and adverse event incidence we will report the results of the analyses as risk ratio (RR), pooled using the Mantel-Haenszel method [7] , with 95% confidence intervals (CIs) with Hartung-Knapp adjustment for random effects model [8] . For Hb, RBC, reticulocyte counts, hematocrit and total bilirubin, we will report the results as mean differences (MDs), pooled using the inverse variance method [9] , with corresponding 95% CIs with Hartung-Knapp adjustment for random effects model [8] .…”

Section: Meta-analysismentioning

confidence: 99%

Efficacy of therapeutic plasma exchange for the treatment of autoimmune hemolytic anemia: Protocol for a meta-analysis of randomized controlled trials

Deng

2020

Preprint

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Autoimmune hemolytic anemia (AIHA) is a rare blood disorder that results in hemolysis of red blood cells (RBCs) due to the presence of autoantibodies in the serum. Previous research has shown that the use of therapeutic plasma exchange therapy (TPE) may be effective at treating AIHA by removing autoimmune antibodies from the intravascular space. However, very little knowledge synthesis is available on the use of TPE in AIHA patients due to the rarity of the disease. We propose a meta-analysis that investigates whether the use of TPE, with or without concurrent treatment regimens, can decrease adverse events, increase remission rate and improve lab results including hemoglobin, RBC, reticulocyte counts, hematocrit and total bilirubin.

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A comparison of methods for meta‐analysis of a small number of studies with binary outcomes

Cited by 94 publications

References 47 publications

The association between digital screen time and myopia: A systematic review

The association between digital screen time and myopia: A systematic review

Prevalence and Clinical Outcome of Philadelphia-Like Acute Lymphoblastic Leukemia: Systematic Review and Meta-analysis

Efficacy of therapeutic plasma exchange for the treatment of autoimmune hemolytic anemia: Protocol for a meta-analysis of randomized controlled trials

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