A comparison of microstructural maturational changes of the corpus callosum in preterm and full-term children: a diffusion tensor imaging study

Jo, Hae Min; Cho, Hee Kyung; Jang, Sung Ho; Yeo, Sang Seok; Lee, Eunsil; Kim, Han Sun; Son, Su Min

doi:10.1007/s00234-012-1042-8

Cited by 24 publications

(25 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our VPT sample we observed greater diffusion and reduced volume, indicating there may be either impairment or delayed development in the white matter tracts of the VPT brain. These findings are consistent with other studies of preterm cohorts that have reported altered microstructural organization in numerous white matter tracts, compared with term-born controls (Nagy et al , 2003, Skranes et al , 2007, Constable et al , 2008, Mullen et al , 2011, Jo et al , 2012, Lee et al , 2013). …”

Section: 4 Discussionsupporting

confidence: 92%

“…Studies also show abnormal microstructural organization in a number of white matter pathways in the preterm brain, including the internal capsule, external capsule, inferior fronto-occipital fasciculus, uncinate fasciculus, superior longitudinal fasciculus, inferior longitudinal fasciculus, centrum semiovale (Nagy et al , 2003, Skranes et al , 2007, Constable et al , 2008, Mullen et al , 2011, Jo et al , 2012, Lee et al , 2013, Groeschel et al , 2014), and corpus callosum (Thompson et al , 2014), which has previously been reported for the current cohort. dMRI studies exploring structure-function associations in preterm cohorts have found that alterations in white matter microstructure are related to motor deficits (Skranes et al , 2007, Counsell et al , 2008, Rose et al , 2009, Thompson et al , 2012, van Kooij et al , 2012, Northam et al , 2012 ), neurosensory impairments (Bassi et al , 2008, Berman et al , 2009, Reiman et al , 2009, Glass et al , 2010, Groppo et al , 2014), and behavioral dysfunction (Nagy et al , 2003, Skranes et al , 2007, Rogers et al , 2012).…”

Section: 1 Introductionsupporting

confidence: 85%

See 1 more Smart Citation

White matter abnormalities and impaired attention abilities in children born very preterm

et al. 2016

View full text Add to dashboard Cite

While attention impairments are commonly observed in very preterm (<32 weeks’ gestational age) children, neuroanatomical correlates of these difficulties are unclear. We aimed to determine whether the microstructural organization of key white matter tracts thought to be involved in attention (cingulum bundle, superior longitudinal fasciculi, reticular activating system, and corpus callosum) were altered in very preterm children compared with term-born controls. We also aimed to determine whether alterations in microstructural organization of these tracts were associated with attention functioning in very preterm children. One hundred and forty-nine very preterm children and 36 term-born controls underwent neuroimaging and assessment of their attention abilities at 7 years. Constrained spherical deconvolution and probabilistic tractography was used to identify the key white matter tracts. Altered microstructural organization and reduced tract volume within reticular activating system and corpus callosum were found in the very preterm group compared with the control group. Diffusion and volume changes in the cingulum bundle, superior longitudinal fasciculi, reticular activating system, and corpus callosum were related to variations in attention functioning in the very preterm children. These findings emphasize that white matter tract integrity is associated with later attentional abilities in very preterm children.

show abstract

Section: 4 Discussionsupporting

confidence: 92%

Section: 1 Introductionsupporting

confidence: 85%

White matter abnormalities and impaired attention abilities in children born very preterm

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Other studies about CC compared preterm and term children with neuroimaging, but the timings of scanning were after a significant postnatal period [3] , [39] , [40] , [50] – [52] . These studies consistently report reduced CC in premature children [3] , [39] , [50] , [51] in comparison to nearly preterm or term born infants [3] , [40] . However, the multiple confounders that influence postnatal brain maturation in the time between birth and imaging comprise the ability to directly associate gestational age at birth to in utero brain development.…”

Section: Discussionmentioning

confidence: 72%

Gestational Age and Neonatal Brain Microstructure in Term Born Infants: A Birth Cohort Study

Broekman

Rifkin‐Graboi

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

ObjectiveUnderstanding healthy brain development in utero is crucial in order to detect abnormal developmental trajectories due to developmental disorders. However, in most studies neuroimaging was done after a significant postnatal period, and in those studies that performed neuroimaging on fetuses, the quality of data has been affected due to complications of scanning during pregnancy. To understand healthy brain development between 37–41 weeks of gestational age, our study assessed the in utero growth of the brain in healthy term born babies with DTI scanning soon after birth.MethodsA cohort of 93 infants recruited from maternity hospitals in Singapore underwent diffusion tensor imaging between 5 to 17 days after birth. We did a cross-sectional examination of white matter microstructure of the brain among healthy term infants as a function of gestational age via voxel-based analysis on fractional anisotropy.ResultsGreater gestational age at birth in term infants was associated with larger fractional anisotropy values in early developing brain regions, when corrected for age at scan. Specifically, it was associated with a cluster located at the corpus callosum (corrected p<0.001), as well as another cluster spanning areas of the anterior corona radiata, anterior limb of internal capsule, and external capsule (corrected p<0.001).ConclusionsOur findings show variation in brain maturation associated with gestational age amongst ‘term’ infants, with increased brain maturation when born with a relatively higher gestational age in comparison to those infants born with a relatively younger gestational age. Future studies should explore if these differences in brain maturation between 37 and 41 weeks of gestational age will persist over time due to development outside the womb.

show abstract

“…Tractography studies also find associations between perinatal diffusion measures and clinical outcomes [ 7 , 16 , 44 , 47 – 52 ] and FA increases with increasing gestational age [ 51 ]. Group differences in diffusion properties of white matter in preterm compared to full term samples have also been investigated in older children [ 9 , 10 , 12 ] and adolescents [ 11 , 13 ]. These structural studies have generally observed decreased mean FA of white matter tracts in the preterm sample compared to the full term sample [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Decreased and Increased Anisotropy along Major Cerebral White Matter Tracts in Preterm Children and Adolescents

et al. 2015

View full text Add to dashboard Cite

Premature birth is highly prevalent and associated with neurodevelopmental delays and disorders. Adverse outcomes, particularly in children born before 32 weeks of gestation, have been attributed in large part to white matter injuries, often found in periventricular regions using conventional imaging. To date, tractography studies of white matter pathways in children and adolescents born preterm have evaluated only a limited number of tracts simultaneously. The current study compares diffusion properties along 18 major cerebral white matter pathways in children and adolescents born preterm (n = 27) and full term (n = 19), using diffusion magnetic resonance imaging and tractography. We found that compared to the full term group, the preterm group had significantly decreased FA in segments of the bilateral uncinate fasciculus and anterior segments of the right inferior fronto-occipital fasciculus. Additionally, the preterm group had significantly increased FA in segments of the right and left anterior thalamic radiations, posterior segments of the right inferior fronto-occipital fasciculus, and the right and left inferior longitudinal fasciculus. Increased FA in the preterm group was generally associated with decreased radial diffusivity. These findings indicate that prematurity-related white matter differences in later childhood and adolescence do not affect all tracts in the periventricular zone and can involve both decreased and increased FA. Differences in the patterns of radial diffusivity and axial diffusivity suggest that the tissue properties underlying group FA differences may vary within and across white matter tracts. Distinctive diffusion properties may relate to variations in the timing of injury in the neonatal period, extent of white matter dysmaturity and/or compensatory processes in childhood.

show abstract

A comparison of microstructural maturational changes of the corpus callosum in preterm and full-term children: a diffusion tensor imaging study

Abstract: The present study shows that thinning of the CC is correlated with lower FA value and that it is more pronounced in preterm children. In addition, the isthmus was found to be the most vulnerable subdivision in preterm children.

Cited by 24 publications

References 47 publications

White matter abnormalities and impaired attention abilities in children born very preterm

White matter abnormalities and impaired attention abilities in children born very preterm

Gestational Age and Neonatal Brain Microstructure in Term Born Infants: A Birth Cohort Study

Decreased and Increased Anisotropy along Major Cerebral White Matter Tracts in Preterm Children and Adolescents

Contact Info

Product

Resources

About