Abstract. Based on commercial software Pro-CAST, The method of moving boundary was adopted to simulate coupled multi-physical field (temperature field, flow field and stress field) of thick-slab continuous casting in mould. Effect of immerged depth and angle of nozzle were studied to improve characteristics of multi-physical fields. The results show that the immerged depth of 120 mm to 140 mm and dip Angle of 15° is a better parameters for the immerged nozzle. Simulation results are basically identical with the actual result, the obtained parameters of immerged nozzle can provide a certain theoretical basis for the actual casting process.