A comparison of mouse and rat liver enzymes and their response to treatment with various compounds

McIntosh, Douglas A. D.; Topham, J.C.

doi:10.1016/0006-2952(72)90407-8

Cited by 14 publications

(3 citation statements)

References 13 publications

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“…T h e mechanism of griseofulvin-induced stimulation of antipyrine metabolism was probably different. In mice, griseofulvin induces an increase in liver weight and despite a lower concentration of cytochrome P-450, aminopyrine demethylase activity in vitro is two-fold higher in griseofulvin-treated mice (McIntosh & Topham, 1972;Denk et al, 1977).…”

Section: Discussionmentioning

confidence: 95%

Antipyrine disposition in calves. I. Effects of some drugs

Depelchin

Bloden

Ansay

1987

Vet Pharm & Therapeutics

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The influence of four drugs on antipyrine pharmacokinetic parameters was studied after 3 h, 2 and 6 days in 32 Friesian calves. Dexamethasone phosphate and griseofulvin led to increased antipyrine elimination. The effect of dexamethasone remained significant 2 and 6 days later. The rate of antipyrine elimination was markedly but transiently depressed by chloramphenicol and oxytetracycline. The apparent volume of antipyrine distribution remained unaltered during treatment.

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Section: Discussionmentioning

confidence: 95%

Antipyrine disposition in calves. I. Effects of some drugs

Depelchin

Bloden

Ansay

1987

Vet Pharm & Therapeutics

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“…Kemp (13) noted minor but common hepatotoxic effects for phenothiazines. Chronic administration of chlorpromazine has been found to increase LOH activity in the rat, along with increasing liver weight (34). The immediate, acute effect of chlorpromazine on LOH activity appears to be inhibitory (35,36) so the increase in LOH activity observed over chronic administration may be the result of long term hepatotoxicity of the drug.…”

Section: Discussionmentioning

confidence: 99%

Clinical Blood Chemistry Values and Long Acting Phenothiazines

Schneider

Kirby

1981

Pharmacopsychiatry

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Fifty-nine chronic schizophrenic patients received one year of treatment with either fluphenazine enanthate or pipothiazine palmitate IM. Both long acting neuroleptics significantly decreased serum albumin, total protein and creatinine values. Triglycerides were decreased only early in treatment. Pretreatment findings from therapy responders, as compared with those who failed to respond to treatment, included higher albumin values and to a lesser extent, lower lactic dehydrogenase values and greater height. These results were discussed with an eye toward the hepatocellular effects of long acting phenothiazines and the effect of liver function on the pharmacokinetics of these medications.

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“…There is enough evidence to suggest that phenobarbitone enhances the rate of drug metabolism, particularly that mediated by the cytochrome P-450 system, in vivo (for a review, see Remmer, 1972), and for this to occur it seems reasonable to suggest that phenobarbitone increasesthe liver NADPH concentration. An increase ofabout 2.5-fold in the liver nucleotide concentration has, in fact, been observed (McIntosh & Topham, 1972) after 14 days of supplying phenobarbitone (0.2 %Y, w/w) in the rat's diet. It has also been shown, by histochemical methods, that the so-called type 1 hydrogen representing NADPH used in microsomal reactions (Altman, 1971), and which is 2.5 times as great in the centrilobular hepatocytes as in the peripheral cells, is increased 4 days after phenobarbitone administration in drinking water (1 mg/ml) to 2.5 times the values found in the corresponding hepatocytes of control rats (Butcher, 1971).…”

Section: Normal Ratsmentioning

confidence: 94%