A comparison of ocular blood flow in untreated primary open-angle glaucoma and ocular hypertension

Comparison of intraocular pressure measured by Pascal dynamic contour tonometry and Goldmann applanation tonometry

“…36 In our study, the mean OPA was 2.871.2 mmHg, a value slightly lower than that in another study utilizing the SmartLens dynamic observing tonometer, 35 but in agreement with other studies based on a pneumotonometer linked to an ocular blood flow system. 37,38 However, unlike Schwenn et al, 35 we did not find a significant difference in OPA between subjects with and without glaucoma (P ¼ 0.13).…”

Ischemic model of optic nerve injury

“…[67][68][69] Apoptosis is a cell death pathway in which a complex cascade of cellular events occurs, including nuclear clumping, DNA condensation, cellular shrinkage and involution, and, finally, macrophage engulfment without inflammation. [70][71][72][73] As the genetic information necessary for apoptosis exists in neural cells (including the retinal ganglion cells), the question becomes, What is the initiating signal that leads to this terminal cascade of events? Potential initiating signals of apoptosis in central nervous system diseases include growth factor deprivation, excitotoxicity, oxygen free radical production, nitric oxide synthesis, and abnormalities of calcium metabolism.…”

A Vascular Approach to Glaucoma

“…Laser Doppler flowmetry showed a decrease in retinal and optic nerve flow in glaucoma patients (Kerr, 1997) (Grunwald, 1998). Furthermore, measurements of pulsatile OBF showed it to be significantly lower in normotensional glaucoma eyes with or without field-loss than in normal subjects (Fontana, 1998).…”