A Comparison of Oestriol and Oestradiol in the Female Rat

A Comparison of the Specific Effects of Oestriol and Oestradiol on the Uterine Body and Cervix of the Spayed Rat

“…They concluded that 'oestriol should be used to influence the cervix and vagina when one does not want to influence the endometrium, for example in senile vaginitis and in dysmenorrhoea'. Overbeck & de Visser (1958) con¬ firmed this work in the spayed rat, and further support was given by Kusuda & Matsumato (1963 and other studies referred to in that paper). The subject was reviewed by Merrill (1958).…”

“…The action of oestriol, however, has been shown to be short-lived compared with that of oestradiol (Miller, 1969). Oestriol, there¬ fore, has a weak uterotrophic action in tests employing daily or single injections (see Rubin, Dorfman, Black & Dorfman, 1951;Overbeck & de Visser, 1958) but Miller (1969) Oestriol, oestradiol and spayed rat uterus 291 were found after single or daily injections because of the differences in retention of oestriol and oestradiol by the target organ. As oestriol is produced continu¬ ously in human pregnancy, this explanation does not contradict the idea that oestriol may have a pronounced effect on the cervix but if it does do so, it will be owing to its inherent oestrogenic potency and the amounts involved rather than to any specific effect.…”

Effects of some drugs on ripening of uterine cervix in nonpregnant castrated and pregnant rats.

“…The stimulating effects of estrogen (E) on ripening of the uterine cervix of human beings and animals were reported by many workers (Puck and Hiibner 1956;Puck et al 1957;Puck 1958;Overbeek and de Visser 1958;Boglin 1959;Kushima et al 1961).…”

The Medical Treatment of Stress Incontinence

“…Quinestradol (‘Pentovis’) has been used in the treatment of senile vulvo‐vaginitis. It is well tolerated and has minimal side effects (Bigby, 1966; Fisher and Wingate, 1966) and it is claimed that its main effects are upon the external genitalia, cervix and vagina and not upon the ovaries and endometrium (Overbeck & De Visser 1958). Because of its selective action it has been used with some effect to treat urinary symptoms in postmenopausal women (Beaton 1967).…”