A comparison of ondansetron and prochlorperazine for the prevention of nàusea and vomiting after tympanoplasty

Berg, A. A. Van Den

doi:10.1007/bf03011808

Cited by 21 publications

(8 citation statements)

References 17 publications

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“…PONV is a common and distressing side effect in patients undergoing tympanomastoid surgery. 1–5 In our study, we found that the total incidence of PONV was 65% in patients undergoing tympanomastoid surgery when no antiemetic was given prophylactically. Following pretreatment with dexamethasone, the incidence of PONV was significantly reduced to 20%.…”

Section: Discussionmentioning

confidence: 58%

“…[2][3][4][5] Apart from these parasympathetic nerve stimulations, intraoperative use of isoflurane and fentanyl, and postoperative pain, may also contribute to these episodes. [1][2][3][4][5]8,17 Because any of these factors could interfere with the interpretation of the study results, we controlled for all of these factors within the study design. All patients underwent tympanomastoid surgery under general anesthesia through a standardized anesthetic and surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

“…Sample size was predetermined by using a power analysis based on the assumptions that 1) the total incidence of nausea and vomiting in the saline group would be 60%, 1–5 2) a 40% reduction in the total incidence of nausea and vomiting (from 60% to 36%) in the treatment group would be of clinical relevance, and 3) α = 0.05, β = 0.2. 15 The analysis showed that 40 patients per group would be sufficient.…”

Section: Methodsmentioning

confidence: 99%

“…Postoperative nausea and vomiting (PONV) is an unpleasant, distressing, and exhausting experience for patients. 1–5 In patients undergoing tympanomastoid surgery, 50% to 80% of patients reported PONV. 1–5 Among the antiemetic currently used, 5‐HT 3 antagonists (e.g., ondansetron, granisetron) possess good efficacy, but cost limits their widespread clinical application.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] In patients undergoing tympanomastoid surgery, 50% to 80% of patients reported PONV. [1][2][3][4][5] Among the antiemetic currently used, 5-HT 3 antagonists (e.g., ondansetron, granisetron) possess good efficacy, but cost limits their widespread clinical application. [5][6][7][8] Dopamine receptor antagonists (e.g., droperidol, prochlorperazine, metoclopramide) are commonly used antiemetics, but are associated with a variety of extrapyramidal symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Use of Dexamethasone on the Prophylaxis of Nausea and Vomiting After Tympanomastoid Surgery

Liu

Wang

et al. 2001

The Laryngoscope

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Use of Dexamethasone on the Prophylaxis of Nausea and Vomiting After Tympanomastoid Surgery

Liu

Wang

et al. 2001

The Laryngoscope

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Drugs for preventing postoperative nausea and vomiting

Carlisle

Stevenson²

2006

Cochrane Database of Systematic Reviews

227

133

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Either nausea or vomiting is reported to affect, at most, 80 out of 100 people after surgery. If all 100 of these people are given one of the listed drugs, about 28 would benefit and 72 would not. Nausea and vomiting are usually less common and, therefore, drugs are less useful. For 100 people, of whom 30 would vomit or feel sick after surgery if given placebo, 10 people would benefit from a drug and 90 would not. Between one to five patients out of every 100 people may experience a mild side effect, such as sedation or headache, when given an antiemetic drug. Collaborative research should focus on determining whether antiemetic drugs cause more severe, probably rare, side effects. Further comparison of the antiemetic effect of one drug versus another is not a research priority.

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