A Comparison of Oral Transmucosal Fentanyl Citrate and Oral Hydromorphone for Inpatient Pediatric Burn Wound Care Analgesia

Burn Rehabilitation

“…Two level III studies compared the effectiveness of oral fentanyl compared with oral morphine or hydromorphone in the management of procedural wound care pain. 186,187 In both studies, the fentanyl group had significant improvement in pain scores during wound care. In a level III study, Finn et al 188 found no difference in procedure-related pain comparing intranasal fentanyl and oral morphine.…”

“…152,176 -181 One level III 153 and four level IV prognostic studies were reviewed. 152,177,178,182 In the pharmacologic therapeutic study category, two level II, 183,184 four level III, [185][186][187][188] and four level IV studies 189 -192 were reviewed. For nonpharmacologic therapeutic studies, there was one level II study, 193 two level III studies, 194,195 and ten level IV studies.…”

Tablets and Other Solid Dosage Forms for Systemic Oral Mucosal Drug Delivery

“…Two double-blinded comparative studies evaluated the analgesia for pediatric burn wound care on inpatient and outpatient basis with OTFC compared to oral hydromorphone, and oral oxycodone, respectively [67,68]. The OTFC showed much improved pain scores before wound care and better anxiolysis during wound care compared to hydromorphone, with similar results and improved palatability compared to oxycodone.…”

Tumordurchbruchschmerz

“…So wurde in mehreren Studien auch die Einsatzmöglichkeit in der Akutschmerztherapie untersucht. Nach orthopädischen [17], viszeralchirurgisch abdominellen Eingriffen [14] und bei der Wundbehandlung nach Verbrennungen [18,19] zeigte sich eine effektive Analgesie. Bei Kindern war die Schmerzreduktion bei Frakturen der unteren Extremität im Vergleich zu i.v.-appliziertem Morphin nach 15 min gleich, bei Studienende nach 75 min sogar besser [20].…”